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Late-life depression (LLD) is a highly prevalent mood disorder occurring in older adults and is frequently accompanied by cognitive impairment (CI). Studies have shown that LLD may increase the risk of Alzheimer's disease (AD). However, the…

Image and Video Processing · Electrical Eng. & Systems 2022-12-27 Lintao Zhang , Lihong Wang , Minhui Yu , Rong Wu , David C. Steffens , Guy G. Potter , Mingxia Liu

Robot assistants for older adults and people with disabilities need to interact with their users in collaborative tasks. The core component of these systems is an interaction manager whose job is to observe and assess the task, and infer…

We present a connectome-informed LLM framework that encodes dynamic fMRI connectivity as temporal sequences, applies robust normalization, and maps these data into a representation suitable for a frozen pre-trained LLM for clinical…

Computation and Language · Computer Science 2025-10-29 Tananun Songdechakraiwut

Multiple modalities of biomarkers have been proved to be very sensitive in assessing the progression of Alzheimer's disease (AD), and using these modalities and machine learning algorithms, several approaches have been proposed to assist in…

Machine Learning · Statistics 2017-12-05 Chen Fang , Panuwat Janwattanapong , Chunfei Li , Malek Adjouadi

Reinforcement learning (RL) for large language models (LLMs) has shown strong performance in single-turn tasks, but extending it to multi-turn interaction remains challenging due to sparse rewards and poor per-turn credit assignment. In…

Computation and Language · Computer Science 2026-05-06 Naifan Zhang , Ruihan Sun , Jinwei Su , Hengjie Yang , Zhengyuan Pan , Zhaohan Chen , Xiaofan Zhang

Delirium represents a significant clinical concern characterized by high morbidity and mortality rates, particularly in patients with mild cognitive impairment (MCI). This study investigates the associated risk factors for delirium by…

Conventional augmentative and alternative communication (AAC) systems and language-learning platforms often fail to adapt in real time to the user's cognitive and linguistic needs, especially in neurological conditions such as post-stroke…

Human-Computer Interaction · Computer Science 2025-08-01 Ismail Hossain , Mridul Banik

Cochlear implants (CI) significantly improve spoken language in children with severe-to-profound sensorineural hearing loss (SNHL), yet outcomes remain more variable than in children with normal hearing. This variability cannot be reliably…

Computation and Language · Computer Science 2025-11-17 Yanlin Wang , Di Yuan , Shani Dettman , Dawn Choo , Emily Shimeng Xu , Denise Thomas , Maura E Ryan , Patrick C M Wong , Nancy M Young

Artificial intelligence progresses towards the "Era of Experience," where agents are expected to learn from continuous, grounded interaction. We argue that traditional Reinforcement Learning (RL), which typically represents value as a…

Machine Learning · Computer Science 2025-05-29 Xidong Feng , Bo Liu , Yan Song , Haotian Fu , Ziyu Wan , Girish A. Koushik , Zhiyuan Hu , Mengyue Yang , Ying Wen , Jun Wang

Reinforcement Learning (RL) has emerged as a powerful paradigm for training LLM-based agents, yet remains limited by low sample efficiency, stemming not only from sparse outcome feedback but also from the agent's inability to leverage prior…

Machine Learning · Computer Science 2026-03-19 Dilxat Muhtar , Jiashun Liu , Wei Gao , Weixun Wang , Shaopan Xiong , Ju Huang , Siran Yang , Wenbo Su , Jiamang Wang , Ling Pan , Bo Zheng

Mild Cognitive Impairment (MCI) affects 15-20% of adults aged 65 and older, often making kitchen navigation and independent living difficult, particularly in lower-income communities with limited access to professional design help. This…

Human-Computer Interaction · Computer Science 2026-04-16 Ibrahim Bilau , Nicole Li , Terrence Malayvong , Eunhwa Yang

Recent advances in fine-tuning large language models (LLMs) with reinforcement learning (RL) have shown promising improvements in complex reasoning tasks, particularly when paired with chain-of-thought (CoT) prompting. However, these…

Machine Learning · Computer Science 2025-04-04 Hung Le , Dai Do , Dung Nguyen , Svetha Venkatesh

This paper explores deterioration in Alzheimers Disease using Machine Learning. Subjects were split into two datasets based on baseline diagnosis (Cognitively Normal, Mild Cognitive Impairment), with outcome of deterioration at final visit…

Machine Learning · Computer Science 2023-06-21 Henry Musto , Daniel Stamate , Ida Pu , Daniel Stahl

Alzheimer Disease poses a significant challenge, necessitating early detection for effective intervention. MRI is a key neuroimaging tool due to its ease of use and cost effectiveness. This study analyzes machine learning methods for MRI…

Neurons and Cognition · Quantitative Biology 2024-08-12 Alwani Liyana Ahmad , Jose Sanchez-Bornot , Roberto C. Sotero , Damien Coyle , Zamzuri Idris , Ibrahima Faye

In Integrated Sensing And Communication (ISAC) systems, estimating the micro-Doppler (mD) spectrogram of a target requires combining channel estimates retrieved from communication with ad-hoc sensing packets, which cope with the sparsity of…

Signal Processing · Electrical Eng. & Systems 2024-12-05 Federico Mason , Jacopo Pegoraro

Recent studies have shown promising results in the detection of Mild Cognitive Impairment (MCI) using easily accessible Electroencephalogram (EEG) data which would help administer early and effective treatment for dementia patients.…

Signal Processing · Electrical Eng. & Systems 2025-01-31 Aayush Mishra , David Joffe , Sankara Surendra Telidevara , David S Oakley , Anqi Liu

Machine Learning (ML) is a common tool to interpret and predict the behavior of distributed computing systems, e.g., to optimize the task distribution between devices. As more and more data is created by Internet of Things (IoT) devices,…

Systems and Control · Electrical Eng. & Systems 2023-11-20 Boris Sedlak , Victor Casamayor Pujol , Praveen Kumar Donta , Schahram Dustdar

Recent advancements in large language models (LLMs) have shown their potential across both general and domain-specific tasks. However, there is a growing concern regarding their lack of sensitivity, factual incorrectness in responses,…

Computation and Language · Computer Science 2025-12-01 Vivek Kumar , Pushpraj Singh Rajawat , Eirini Ntoutsi

Nowadays, a lot of scientific efforts are concentrated on the diagnosis of Alzheimer's Disease (AD) applying deep learning methods to neuroimaging data. Even for 2017, there were published more than a hundred papers dedicated to AD…

Machine Learning · Computer Science 2018-07-31 Yaroslav Shmulev , Mikhail Belyaev

Alzheimer's Disease (AD) ravages the cognitive ability of more than 5 million Americans and creates an enormous strain on the health care system. This paper proposes a machine learning predictive model for AD development without medical…

Quantitative Methods · Quantitative Biology 2020-06-17 Courtney Cochrane , David Castineira , Nisreen Shiban , Pavlos Protopapas