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Alzheimer's Disease (AD) is a neurodegenerative disease that affects subjects in a broad range of severity and is assessed in clinical trials with multiple cognitive and functional instruments. As clinical trials in AD increasingly focus on…

Increasing demand for algorithms that can learn quickly and efficiently has led to a surge of development within the field of artificial intelligence (AI). An important paradigm within AI is reinforcement learning (RL), where agents…

Mediation analysis learns the causal effect transmitted via mediator variables between treatments and outcomes and receives increasing attention in various scientific domains to elucidate causal relations. Most existing works focus on…

Machine Learning · Statistics 2023-09-06 Lin Ge , Jitao Wang , Chengchun Shi , Zhenke Wu , Rui Song

Effective dementia caregiving requires training and adaptive communication, but assistive AI and robotics are constrained by a lack of context-rich, privacy-sensitive data on how people living with Alzheimer's disease and related dementias…

Human-Computer Interaction · Computer Science 2026-04-01 Kruthika Gangaraju , Shu-Fen Wung , Kevin Berner , Jing Wang , Fengpei Yuan

Reliable detection of the prodromal stages of Alzheimer's disease (AD) remains difficult even today because, unlike other neurocognitive impairments, there is no definitive diagnosis of AD in vivo. In this context, existing research has…

Machine Learning · Computer Science 2021-08-03 Amish Mittal , Sourav Sahoo , Arnhav Datar , Juned Kadiwala , Hrithwik Shalu , Jimson Mathew

Persuasion dialogue systems reflect the machine's ability to make strategic moves beyond verbal communication, and therefore differentiate themselves from task-oriented or open-domain dialogue systems and have their own unique values.…

Computation and Language · Computer Science 2022-10-25 Weiyan Shi , Yu Li , Saurav Sahay , Zhou Yu

There is a pressing need to automatically understand the state and progression of chronic neurological diseases such as dementia. The emergence of state-of-the-art sensing platforms offers unprecedented opportunities for indirect and…

Computers and Society · Computer Science 2020-07-08 Rafael Poyiadzi , Weisong Yang , Yoav Ben-Shlomo , Ian Craddock , Liz Coulthard , Raul Santos-Rodriguez , James Selwood , Niall Twomey

Alzheimer's disease (AD) stands as the predominant cause of dementia, characterized by a gradual decline in speech and language capabilities. Recent deep-learning advancements have facilitated automated AD detection through spontaneous…

Computation and Language · Computer Science 2024-09-20 Chin-Po Chen , Jeng-Lin Li

Creating personalized and adaptable conversational AI remains a key challenge. This paper introduces a Continuous Learning Conversational AI (CLCA) approach, implemented using A2C reinforcement learning, to move beyond static Large Language…

Artificial Intelligence · Computer Science 2025-02-19 Nandakishor M , Anjali M

The rapid global aging trend has led to an increase in dementia cases, including Alzheimer's disease, underscoring the urgent need for early and accurate diagnostic methods. Traditional diagnostic techniques, such as cognitive tests,…

Machine Learning · Computer Science 2024-09-06 Juan A. Berrios Moya

With people living longer than ever, the number of cases with dementia such as Alzheimer's disease increases steadily. It affects more than 46 million people worldwide, and it is estimated that in 2050 more than 100 million will be…

Multimedia · Computer Science 2021-01-20 Mariona Caros , Maite Garolera , Petia Radeva , Xavier Giro-i-Nieto

Objective: We aimed to develop and validate a novel multimodal framework HiMAL (Hierarchical, Multi-task Auxiliary Learning) framework, for predicting cognitive composite functions as auxiliary tasks that estimate the longitudinal risk of…

Machine Learning · Computer Science 2026-02-06 Sayantan Kumar , Sean Yu , Andrew Michelson , Thomas Kannampallil , Philip Payne

Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that leads to dementia, and early intervention can greatly benefit from analyzing linguistic abnormalities. In this work, we explore the potential of Large Language Models…

Computation and Language · Computer Science 2025-12-23 Chuyuan Li , Raymond Li , Thalia S. Field , Giuseppe Carenini

We evaluate cognitive impairment (CI) classification from transcripts of speech in English, Slovene, and Korean. We compare zero-shot large language models (LLMs) used as direct classifiers under three input settings -- transcript-only,…

Computation and Language · Computer Science 2026-04-09 Damar Hoogland , Boshko Koloski , Jaya Caporusso , Tine Kolenik , Ana Zwitter Vitez , Senja Pollak , Christina Manouilidou , Matthew Purver

Dementia with Lewy bodies is the second most common type of neurodegenerative dementia, and identification at the prodromal stage$-$i.e., mild cognitive impairment due to Lewy bodies (MCI-LB)$-$is important for providing appropriate care.…

Signal Processing · Electrical Eng. & Systems 2023-09-19 Masatomo Kobayashi , Yasunori Yamada , Kaoru Shinkawa , Miyuki Nemoto , Miho Ota , Kiyotaka Nemoto , Tetsuaki Arai

Agents capable of carrying out general tasks on a computer can improve efficiency and productivity by automating repetitive tasks and assisting in complex problem-solving. Ideally, such agents should be able to solve new computer tasks…

Computation and Language · Computer Science 2023-11-20 Geunwoo Kim , Pierre Baldi , Stephen McAleer

Language systems have been of great interest to the research community and have recently reached the mass market through various assistant platforms on the web. Reinforcement Learning methods that optimize dialogue policies have seen…

Machine Learning · Computer Science 2024-02-09 Floris den Hengst , Mark Hoogendoorn , Frank van Harmelen , Joost Bosman

Traditionally, Reinforcement Learning (RL) aims at deciding how to act optimally for an artificial agent. We argue that deciding when to act is equally important. As humans, we drift from default, instinctive or memorized behaviors to…

Machine Learning · Computer Science 2022-03-17 Alexis Jacq , Johan Ferret , Olivier Pietquin , Matthieu Geist

Background and Aim: Accurate classification of Magnetic Resonance Images (MRI) is essential to accurately predict Mild Cognitive Impairment (MCI) to Alzheimer's Disease (AD) conversion. Meanwhile, deep learning has been successfully…

Computer Vision and Pattern Recognition · Computer Science 2021-09-03 Kshitiz Shrestha , Omar Hisham Alsadoon , Abeer Alsadoon , Tarik A. Rashid , Rasha S. Ali , P. W. C. Prasad , Oday D. Jerew

Alzheimer's disease (AD) progression follows a complex continuum from normal cognition (NC) through mild cognitive impairment (MCI) to dementia, yet most deep learning approaches oversimplify this into discrete classification tasks. This…

Image and Video Processing · Electrical Eng. & Systems 2025-08-05 Yufeng Jiang , Hexiao Ding , Hongzhao Chen , Jing Lan , Xinzhi Teng , Gerald W. Y. Cheng , Zongxi Li , Haoran Xie , Jung Sun Yoo , Jing Cai