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Multiple instance learning (MIL) is often used in medical imaging to classify high-resolution 2D images by processing patches or classify 3D volumes by processing slices. However, conventional MIL approaches treat instances separately,…

Machine Learning · Computer Science 2025-11-13 Ethan Harvey , Dennis Johan Loevlie , Michael C. Hughes

Multi-Instance Learning (MIL) has shown impressive performance for histopathology whole slide image (WSI) analysis using bags or pseudo-bags. It involves instance sampling, feature representation, and decision-making. However, existing…

Computer Vision and Pattern Recognition · Computer Science 2024-03-14 Tingting Zheng , Kui Jiang , Hongxun Yao

Multiple instance data are sets or multi-sets of unordered elements. Using metrics or distances for sets, we propose an approach to several multiple instance learning tasks, such as clustering (unsupervised learning), classification…

Machine Learning · Computer Science 2017-03-28 Quang N. Tran , Ba-Ngu Vo , Dinh Phung , Ba-Tuong Vo , Thuong Nguyen

Classification and localization are two pillars of visual object detectors. However, in CNN-based detectors, these two modules are usually optimized under a fixed set of candidate (or anchor) bounding boxes. This configuration significantly…

Computer Vision and Pattern Recognition · Computer Science 2019-12-06 Wei Ke , Tianliang Zhang , Zeyi Huang , Qixiang Ye , Jianzhuang Liu , Dong Huang

Multi-Instance Multi-Label learning (MIML) models complex objects (bags), each of which is associated with a set of interrelated labels and composed with a set of instances. Current MIML solutions still focus on a single-type of objects and…

Machine Learning · Computer Science 2021-11-09 Yuanlin Yang , Guoxian Yu , Jun Wang , Lei Liu , Carlotta Domeniconi , Maozu Guo

Single-cell datasets often lack individual cell labels, making it challenging to identify cells associated with disease. To address this, we introduce Mixture Modeling for Multiple Instance Learning (MMIL), an expectation maximization…

Quantitative Methods · Quantitative Biology 2024-06-13 Erin Craig , Timothy Keyes , Jolanda Sarno , Maxim Zaslavsky , Garry Nolan , Kara Davis , Trevor Hastie , Robert Tibshirani

Novelty detection plays an important role in machine learning and signal processing. This paper studies novelty detection in a new setting where the data object is represented as a bag of instances and associated with multiple class labels,…

Machine Learning · Computer Science 2013-12-02 Qi Lou , Raviv Raich , Forrest Briggs , Xiaoli Z. Fern

Multiple instance learning (MIL) has become the leading approach for extracting discriminative features from whole slide images (WSIs) in computational pathology. Attention-based MIL methods can identify key patches but tend to overlook…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Lubin Gan , Xiaoman Wu , Jing Zhang , Zhifeng Wang , Linhao Qu , Siying Wu , Xiaoyan Sun

Whole Slide Image (WSI) classification remains a challenge due to their extremely high resolution and the absence of fine-grained labels. Presently, WSI classification is usually regarded as a Multiple Instance Learning (MIL) problem when…

Computer Vision and Pattern Recognition · Computer Science 2023-08-24 Hongyi Wang , Luyang Luo , Fang Wang , Ruofeng Tong , Yen-Wei Chen , Hongjie Hu , Lanfen Lin , Hao Chen

We present an attention-based model for recognizing multiple objects in images. The proposed model is a deep recurrent neural network trained with reinforcement learning to attend to the most relevant regions of the input image. We show…

Machine Learning · Computer Science 2015-04-24 Jimmy Ba , Volodymyr Mnih , Koray Kavukcuoglu

One way to extract patterns from clinical records is to consider each patient record as a bag with various number of instances in the form of symptoms. Medical diagnosis is to discover informative ones first and then map them to one or more…

Machine Learning · Computer Science 2019-04-10 Zeyuan Wang , Josiah Poon , Shiding Sun , Simon Poon

State-of-the-art audio event detection (AED) systems rely on supervised learning using strongly labeled data. However, this dependence severely limits scalability to large-scale datasets where fine resolution annotations are too expensive…

Sound · Computer Science 2018-03-28 Shao-Yen Tseng , Juncheng Li , Yun Wang , Joseph Szurley , Florian Metze , Samarjit Das

Weakly supervised object detection (WSOD) is a challenging task that requires simultaneously learn object classifiers and estimate object locations under the supervision of image category labels. A major line of WSOD methods roots in…

Computer Vision and Pattern Recognition · Computer Science 2022-05-06 Shiwei Zhang , Wei Ke , Lin Yang

Pathological image analysis is an important process for detecting abnormalities such as cancer from cell images. However, since the image size is generally very large, the cost of providing detailed annotations is high, which makes it…

Computer Vision and Pattern Recognition · Computer Science 2023-04-10 Shusuke Takahama , Yusuke Kurose , Yusuke Mukuta , Hiroyuki Abe , Akihiko Yoshizawa , Tetsuo Ushiku , Masashi Fukayama , Masanobu Kitagawa , Masaru Kitsuregawa , Tatsuya Harada

Multiple instance learning (MIL) stands as a powerful approach in weakly supervised learning, regularly employed in histological whole slide image (WSI) classification for detecting tumorous lesions. However, existing mainstream MIL methods…

Image and Video Processing · Electrical Eng. & Systems 2024-07-08 Wenhui Zhu , Xiwen Chen , Peijie Qiu , Aristeidis Sotiras , Abolfazl Razi , Yalin Wang

This paper addresses the challenges posed by the unstructured nature and high-dimensional semantic complexity of electronic health record texts. A deep learning method based on attention mechanisms is proposed to achieve unified modeling…

Computation and Language · Computer Science 2025-07-03 Ting Xu , Xiaoxiao Deng , Xiandong Meng , Haifeng Yang , Yan Wu

Multi-instance learning (MIL) is widely used in the computer-aided interpretation of pathological Whole Slide Images (WSIs) to solve the lack of pixel-wise or patch-wise annotations. Often, this approach directly applies "natural image…

Learning accurate object detectors often requires large-scale training data with precise object bounding boxes. However, labeling such data is expensive and time-consuming. As the crowd-sourcing labeling process and the ambiguities of the…

Computer Vision and Pattern Recognition · Computer Science 2022-07-21 Chengxin Liu , Kewei Wang , Hao Lu , Zhiguo Cao , Ziming Zhang

Multiple instance learning (MIL) has been extensively applied to whole slide histopathology image (WSI) analysis. The existing aggregation strategy in MIL, which primarily relies on the first-order distance (e.g., mean difference) between…

Computer Vision and Pattern Recognition · Computer Science 2024-07-22 Yihang Chen , Tsai Hor Chan , Guosheng Yin , Yuming Jiang , Lequan Yu

Hispathological image segmentation algorithms play a critical role in computer aided diagnosis technology. The development of weakly supervised segmentation algorithm alleviates the problem of medical image annotation that it is…

Computer Vision and Pattern Recognition · Computer Science 2022-05-19 Ziniu Qian , Kailu Li , Maode Lai , Eric I-Chao Chang , Bingzheng Wei , Yubo Fan , Yan Xu