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Foundation models in genomics have shown mixed success compared to their counterparts in natural language processing. Yet, the reasons for their limited effectiveness remain poorly understood. In this work, we investigate the role of…

Machine Learning · Computer Science 2026-04-07 Maxime Rochkoulets , Lovro Vrček , Mile Šikić

In this paper we study time semi-discrete approximations of a class of exponentially stable infinite dimensional systems with unbounded feedbacks. It has recently been proved that for time semi-discrete systems, due to high frequency…

Optimization and Control · Mathematics 2013-06-18 Zayd Hajjej , Mohamed Balegh

The goal of this paper is to develop an estimate for the entropy of random long-range correlated symbolic sequences with elements belonging to a finite alphabet. As a plausible model, we use the high-order additive stationary ergodic Markov…

Information Theory · Computer Science 2014-12-12 S. S. Melnik , O. V. Usatenko

For multivariant Wright-Fisher models in population genetics, we introduce equilibrium states, expressed by fluctuations of probability ratio, in contrast to the traditionally used fluctuations, expressed by the difference between the…

Statistics Theory · Mathematics 2020-08-04 D. Koroliouk , V. S. Koroliuk

The complexity of the primary structure of human DNA is explored using methods from nonequilibrium statistical mechanics, dynamical systems theory and information theory. The use of chi-square tests shows that DNA cannot be described as a…

Genomics · Quantitative Biology 2015-06-17 A. Provata , C. Nicolis , G. Nicolis

The study of the entanglement dynamics plays a fundamental role in understanding the behaviour of many-body quantum systems out of equilibrium. In the presence of a globally conserved charge, further insights are provided by the knowledge…

Statistical Mechanics · Physics 2023-03-31 Gilles Parez , Riccarda Bonsignori , Pasquale Calabrese

We show that the dynamics of generic quantum systems concentrate around their equilibrium value when measuring at arbitrary times. This means that the probability of finding them away from equilibrium is exponentially suppressed, with a…

Quantum Physics · Physics 2023-11-03 Jonathon Riddell , Nathan Pagliaroli , Álvaro M. Alhambra

We consider the integrable family of symmetric boundary-driven interacting particle systems that arise from the non-compact XXX Heisenberg model in one dimension with open boundaries. In contrast to the well-known symmetric exclusion…

Mathematical Physics · Physics 2024-05-27 Rouven Frassek , Cristian Giardinà

Recent years have seen tremendous progress in the theoretical understanding of quantum systems driven dissipatively by coupling them to different baths at their edges. This was possible because of the concurrent advances in the models used…

Quantum Physics · Physics 2022-12-15 Gabriel T. Landi , Dario Poletti , Gernot Schaller

The confinement of elementary excitations induces distinctive features in the non-equilibrium quench dynamics. One of the most remarkable is the suppression of entanglement entropy which in several instances turns out to oscillate rather…

Statistical Mechanics · Physics 2022-03-17 Stefano Scopa , Pasquale Calabrese , Alvise Bastianello

Nonequilibrium processes break time-reversal symmetry and generate entropy. Living systems are driven out-of-equilibrium at the microscopic level of molecular motors that exploit chemical potential gradients to transduce free energy to…

Statistical Mechanics · Physics 2022-12-06 Eden Nitzan , Aishani Ghosal , Gili Bisker

Transmission dynamics of infectious diseases are often studied using compartmental mathematical models, which are commonly represented as systems of autonomous ordinary differential equations. A key step in the analysis of such models is to…

Populations and Evolution · Quantitative Biology 2025-12-15 David J. D. Earn , C. Connell McCluskey

Energy-Based Models (EBMs) present a flexible and appealing way to represent uncertainty. Despite recent advances, training EBMs on high-dimensional data remains a challenging problem as the state-of-the-art approaches are costly, unstable,…

Machine Learning · Computer Science 2021-06-08 Will Grathwohl , Jacob Kelly , Milad Hashemi , Mohammad Norouzi , Kevin Swersky , David Duvenaud

In this four-part prospectus, we first give a brief introduction to the motivation for studying entanglement entropy and some recent development. Then follows a summary of our recent work about entanglement entropy in states with…

Quantum Physics · Physics 2009-08-18 Wenxin Ding

For the canonical two-state model of transcription, we derive exact analytic expressions for the entropy production rate of transcription at steady state, and assess detailed balance breaking in transcription. Our analytics allow us to…

Subcellular Processes · Quantitative Biology 2025-11-27 James Holehouse

Moment-closure methods are popular tools to simplify the mathematical analysis of stochastic models defined on networks, in which high dimensional joint distributions are approximated (often by some heuristic argument) as functions of lower…

Data Analysis, Statistics and Probability · Physics 2011-05-25 Tim Rogers

Although asymptotic analyses of undirected network models based on degree sequences have started to appear in recent literature, it remains an open problem to study statistical properties of directed network models. In this paper, we…

Statistics Theory · Mathematics 2016-01-13 Ting Yan , Chenlei Leng , Ji Zhu

Maximum entropy modeling is a flexible and popular framework for formulating statistical models given partial knowledge. In this paper, rather than the traditional method of optimizing over the continuous density directly, we learn a smooth…

Methodology · Statistics 2017-05-01 Gabriel Loaiza-Ganem , Yuanjun Gao , John P. Cunningham

Biological systems are driven by intricate interactions among the complex array of molecules that comprise the cell. Many methods have been developed to reconstruct network models of those interactions. These methods often draw on large…

Molecular Networks · Quantitative Biology 2018-06-29 Marieke Lydia Kuijjer , Matthew Tung , GuoCheng Yuan , John Quackenbush , Kimberly Glass

It is supposed that the exponential multiplier in the method of the non-equilibrium statistical operator (Zubarev`s approach) can be considered as a distribution density of the past lifetime of the system, and can be replaced by an…

Statistical Mechanics · Physics 2009-10-26 V. V. Ryazanov