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Image annotation is one of the most essential tasks for guaranteeing proper treatment for patients and tracking progress over the course of therapy in the field of medical imaging and disease diagnosis. However, manually annotating a lot of…

Computer Vision and Pattern Recognition · Computer Science 2024-03-25 Md Abdul Kadir , Hasan Md Tusfiqur Alam , Pascale Maul , Hans-Jürgen Profitlich , Moritz Wolf , Daniel Sonntag

Expression of human epidermal growth factor receptor 2 (HER2) is an important biomarker in breast cancer patients who can benefit from cost-effective automatic Hematoxylin and Eosin (H\&E) HER2 scoring. However, developing such scoring…

Computer Vision and Pattern Recognition · Computer Science 2024-11-11 Rawan S. Abdulsadig , Bryan M. Williams , Nikolay Burlutskiy

Accurate ground truth estimation in medical screening programs often relies on coalitions of experts and peer second opinions. Algorithms that efficiently aggregate noisy annotations can enhance screening workflows, particularly when data…

Machine Learning · Computer Science 2025-10-07 Tim Bary , Tiffanie Godelaine , Axel Abels , Benoît Macq

The annotation of image and video data of large datasets is a fundamental task in multimedia information retrieval and computer vision applications. In order to support the users during the image and video annotation process, several…

Computer Vision and Pattern Recognition · Computer Science 2015-02-19 Gianluigi Ciocca , Paolo Napoletano , Raimondo Schettini

The discovery of patterns associated with diagnosis, prognosis, and therapy response in digital pathology images often requires intractable labeling of large quantities of histological objects. Here we release an open-source labeling tool,…

Advances in optical microscopy scanning have significantly contributed to computational pathology (CPath) by converting traditional histopathological slides into whole slide images (WSIs). This development enables comprehensive digital…

Image and Video Processing · Electrical Eng. & Systems 2024-11-19 Xitong Ling , Yuanyuan Lei , Jiawen Li , Junru Cheng , Wenting Huang , Tian Guan , Jian Guan , Yonghong He

With the AI revolution in place, the trend for building automated systems to support professionals in different domains such as the open source software systems, healthcare systems, banking systems, transportation systems and many others…

Computation and Language · Computer Science 2024-06-21 Somnath Banerjee , Avik Dutta , Aaditya Agrawal , Rima Hazra , Animesh Mukherjee

Histology review is often used as the `gold standard' for disease diagnosis. Computer aided diagnosis tools can potentially help improve current pathology workflows by reducing examination time and interobserver variability. Previous work…

Computer Vision and Pattern Recognition · Computer Science 2019-05-31 Jiayun Li , Wenyuan Li , Arkadiusz Gertych , Beatrice S. Knudsen , William Speier , Corey W. Arnold

Conventional histopathology has long been essential for disease diagnosis, relying on visual inspection of tissue sections. Immunohistochemistry aids in detecting specific biomarkers but is limited by its single-marker approach, restricting…

Histopathology tissue analysis is considered the gold standard in cancer diagnosis and prognosis. Given the large size of these images and the increase in the number of potential cancer cases, an automated solution as an aid to…

Image and Video Processing · Electrical Eng. & Systems 2020-11-19 Mahendra Khened , Avinash Kori , Haran Rajkumar , Balaji Srinivasan , Ganapathy Krishnamurthi

AI models rely on annotated data to learn pattern and perform prediction. Annotation is usually a labor-intensive step that require associating labels ranging from a simple classification label to more complex tasks such as object…

Computer Vision and Pattern Recognition · Computer Science 2025-09-05 Safouane El Ghazouali , Umberto Michelucci

The fine-grained annotations in whole slide images (WSIs) show the boundaries of various pathological regions. However, generating such detailed annotation is often costly, whereas the coarse annotations are relatively simpler to produce.…

Computer Vision and Pattern Recognition · Computer Science 2025-03-26 Bingjian Yao , Weiping Lin , Yan He , Zheng Wang , Liangsheng Wang

The field of histology relies heavily on antiquated tissue processing and staining techniques that limit the efficiency of pathologic diagnoses of cancer and other diseases. Current staining and advanced labeling methods are often…

This work tackles the automatic fine-grained slide quality assessment problem for digitized direct smears test using the Gram staining protocol. Automatic quality assessment can provide useful information for the pathologists and the whole…

Computer Vision and Pattern Recognition · Computer Science 2018-03-21 Teng Zhang , Johanna Carvajal , Daniel F. Smith , Kun Zhao , Arnold Wiliem , Peter Hobson , Anthony Jennings , Brian C. Lovell

Histopathology slide digitization introduces scanner-induced domain shift that can significantly impact computational pathology models based on deep learning methods. In the state-of-the-art, this shift is often characterized at a broad…

Cell type annotation is critical for understanding cellular heterogeneity. Based on single-cell RNA-seq data and deep learning models, good progress has been made in annotating a fixed number of cell types within a specific tissue. However,…

Computation and Language · Computer Science 2025-04-08 Yuren Mao , Yu Mi , Peigen Liu , Mengfei Zhang , Hanqing Liu , Yunjun Gao

We introduce Fluid Annotation, an intuitive human-machine collaboration interface for annotating the class label and outline of every object and background region in an image. Fluid annotation is based on three principles: (I) Strong…

Computer Vision and Pattern Recognition · Computer Science 2018-12-21 Mykhaylo Andriluka , Jasper R. R. Uijlings , Vittorio Ferrari

Segmentation and classification of cell nuclei in histopathology images using deep neural networks (DNNs) can save pathologists' time for diagnosing various diseases, including cancers, by automating cell counting and morphometric…

Computer Vision and Pattern Recognition · Computer Science 2023-10-06 Amruta Parulekar , Utkarsh Kanwat , Ravi Kant Gupta , Medha Chippa , Thomas Jacob , Tripti Bameta , Swapnil Rane , Amit Sethi

Image annotation aims to annotate a given image with a variable number of class labels corresponding to diverse visual concepts. In this paper, we address two main issues in large-scale image annotation: 1) how to learn a rich feature…

Computer Vision and Pattern Recognition · Computer Science 2018-10-22 Yulei Niu , Zhiwu Lu , Ji-Rong Wen , Tao Xiang , Shih-Fu Chang

Developing clinically useful cell-level analysis tools in digital pathology remains challenging due to limitations in dataset granularity, inconsistent annotations, high computational demands, and difficulties integrating new technologies…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Nikita Shvetsov , Thomas K. Kilvaer , Masoud Tafavvoghi , Anders Sildnes , Kajsa Møllersen , Lill-Tove Rasmussen Busund , Lars Ailo Bongo