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Since the recent introduction of several viable vaccines for SARS-CoV-2, vaccination uptake has become the key factor that will determine our success in containing the COVID-19 pandemic. We argue that game theory and social network models…

We study how the herd immunity threshold and the expected epidemic size depend on homophily with respect to vaccine adoption. We find that the presence of homophily considerably increases the critical vaccine coverage needed for herd…

Physics and Society · Physics 2025-09-03 Takayuki Hiraoka , Abbas K. Rizi , Mikko Kivelä , Jari Saramäki

We consider optimal vaccination protocol where the vaccine is in short supply. In this case, disease extinction results from a large and rare fluctuation. We show that the probability of such fluctuation can be exponentially increased by…

Populations and Evolution · Quantitative Biology 2013-05-29 M. Khasin , M. I. Dykman , B. Meerson

We study a game-theoretic model of epidemic control in a large population with finitely many groups and non-cooperative individuals. In the model, individuals jointly choose their socialization levels and vaccination rates, and vaccination…

Optimization and Control · Mathematics 2026-04-28 Huaning Liu , Gokce Dayanikli

In the face of serious infectious diseases, governments endeavour to implement containment measures such as public vaccination at a macroscopic level. Meanwhile, individuals tend to protect themselves by avoiding contacts with infections at…

Physics and Society · Physics 2016-10-20 Xiao-Long Peng , Xin-Jian Xu , Michael Small , Xinchu Fu , Zhen Jin

We study the spread of an SIRS-type epidemic with vaccination on network. Starting from an exact Markov description of the model, we investigate the mean epidemic lifetime by providing a sufficient condition for fast extinction that depends…

Dynamical Systems · Mathematics 2020-11-23 Stefania Ottaviano , Stefano Bonaccorsi

We consider the problem of controlling the propagation of an epidemic outbreak in an arbitrary contact network by distributing vaccination resources throughout the network. We analyze a networked version of the…

Social and Information Networks · Computer Science 2013-03-19 Victor M. Preciado , Michael Zargham , Chinwendu Enyioha , Ali Jadbabaie , George Pappas

In this work we study the stability properties of the equilibrium points of deterministic epidemic models with nonconstant population size. Models with nonconstant population have been studied in the past only in particular cases, two of…

Optimization and Control · Mathematics 2022-02-25 Florin Avram , Rim Adenane , Lasko Basnarkov , Gianluca Bianchin , Dan Goreac , Andrei Halanay

Vaccination has been proven to be the most effective method to prevent infectious diseases. However, in many low and middle-income countries with geographically dispersed and nomadic populations, last-mile vaccine delivery can be extremely…

Applications · Statistics 2021-04-30 Yuwen Yang , Jayant Rajgopal

Vaccination is essential for the management of infectious diseases, many of which continue to pose devastating public health and economic challenges across the world. However, many vaccines are imperfect having only a partial protective…

Populations and Evolution · Quantitative Biology 2022-08-04 Hetsron L. Nyandjo-Bamen , Jean Marie Ntaganda , Aurelien Tellier , Olivier Menoukeu-Pamen

Modeling human behavior is essential to accurately predict epidemic spread, with behaviors like vaccine hesitancy complicating control efforts. While epidemic spread is often treated as a simple contagion, vaccine uptake may follow complex…

Physics and Society · Physics 2024-12-17 Alfonso de Miguel-Arribas , Alberto Aleta , Yamir Moreno

Compartmental models have long served as important tools in mathematical epidemiology, with their usefulness highlighted by the recent COVID-19 pandemic. However, most of the classical models fail to account for certain features of this…

Dynamical Systems · Mathematics 2023-08-21 Monique Chyba , Taylor Klotz , Yuriy Mileyko , Corey Shanbrom

We develop a mechanistic model that classifies individuals both in terms of epidemiological status (SIR) and vaccination attitude (willing or unwilling), with the goal of discovering how disease spread is influenced by changing opinions…

Dynamical Systems · Mathematics 2024-08-16 Yi Jiang , Kristin M. Kurianski , Jane HyoJin Lee , Yanping Ma , Daniel Cicala , Glenn Ledder

We propose and solve an optimal vaccination problem within a deterministic compartmental model of SIRS type: the immunized population can become susceptible again, e.g.\ because of a not complete immunization power of the vaccine. A social…

Optimization and Control · Mathematics 2022-06-08 Salvatore Federico , Giorgio Ferrari , Maria-Laura Torrente

Seasonal influenza epidemics cause consistent, considerable, widespread loss annually in terms of economic burden, morbidity, and mortality. With access to accurate and reliable forecasts of a current or upcoming influenza epidemic's…

Populations and Evolution · Quantitative Biology 2016-02-17 Logan C. Brooks , David C. Farrow , Sangwon Hyun , Ryan J. Tibshirani , Roni Rosenfeld

Infectious disease outbreaks have precipitated a profusion of mathematical models. Epidemic curves predicted by these models are typically qualitatively similar, despite distinct model assumptions, but there is no theoretical explanation…

Populations and Evolution · Quantitative Biology 2026-02-23 David J. D. Earn , Todd L. Parsons

When the body gets infected by a pathogen or receives a vaccine dose, the immune system develops pathogen-specific immunity. Induced immunity decays in time and years after recovery/vaccination the host might become susceptible again.…

Populations and Evolution · Quantitative Biology 2015-01-15 Maria Vittoria Barbarossa , Gergely Röst

Information diffusion and disease spreading in communication-contact layered network are typically asymmetrically coupled with each other, in which how an individual being aware of disease responds to the disease can significantly affect…

Physics and Society · Physics 2016-06-20 Quan-Hui Liu , Wei Wang , Ming Tang , Hai-Feng Zhang

This paper presents a simple continuous-time linear vaccination-based control strategy for a SEIR (susceptible plus infected plus infectious plus removed populations) propagation disease model. The model takes into account the total…

Dynamical Systems · Mathematics 2011-03-28 M. De la Sen , A. Ibeas , S. Alonso-Quesada

We propose a framework for the description of the effects of vaccinations on the spreading of an epidemic disease. Different vaccines can be dosed, each providing different immunization times and immunization levels. Differences due to…

Analysis of PDEs · Mathematics 2024-07-23 Rinaldo M. Colombo , Mauro Garavello