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Multi-site studies are becoming important to increase statistical power, enhance generalizability, and to improve the likelihood of pooling relevant subgroups together activities. Even with harmonized imaging sequences, site-dependent…

Neurons and Cognition · Quantitative Biology 2019-09-11 Sumra Bari , Enrico Amico , Nicole Vike , Thomas M. Talavage , Joaquín Goñi

Today the human brain can be modeled as a graph where nodes represent different regions and links stand for statistical interactions between their activities as recorded by different neuroimaging techniques. Empirical studies have lead to…

Neurons and Cognition · Quantitative Biology 2017-11-01 J. H. Martínez , J. M. Buldú , D. Papo , F. De Vico Fallani , M. Chavez

Functional connectomes (FCs) contain pairwise estimations of functional couplings based on pairs of brain regions activity. FCs are commonly represented as correlation matrices that are symmetric positive definite (SPD) lying on or inside…

Understanding brain connectivity in a network-theoretic context has shown much promise in recent years. This type of analysis identifies brain organisational principles, bringing a new perspective to neuroscience. At the same time, large…

Neural and Evolutionary Computing · Computer Science 2016-11-28 Sarah Parisot , Jonathan Passerat-Palmbach , Markus D. Schirmer , Boris Gutman

Anatomical connectivity between different regions in the brain can be mapped to a network representation, the connectome, where the intensities of the links, the weights, influence its structural resilience and the functional processes it…

Neurons and Cognition · Quantitative Biology 2025-04-09 Laia Barjuan , Muhua Zheng , M. Ángeles Serrano

Recent work in cognitive neuroscience has focused on analyzing the brain as a network, rather than as a collection of independent regions. Prior studies taking this approach have found that individual differences in the degree of modularity…

Neurons and Cognition · Quantitative Biology 2017-11-28 Qiuhai Yue , Randi Martin , Simon Fischer-Baum , Aurora I. Ramos-Nuñez , Fengdan Ye , Michael W. Deem

In this paper, we use data from the Human Connectome Project (N=461) to investigate the effect of scan length on reliability of resting-state functional connectivity (rsFC) estimates produced from resting-state functional magnetic resonance…

Applications · Statistics 2016-06-22 Amanda F. Mejia , Mary Beth Nebel , Anita D. Barber , Ann S. Choe , Martin A. Lindquist

The brain's structural connectome supports signal propagation between neuronal elements, shaping diverse coactivation patterns that can be captured as functional connectivity. While the link between structure and function remains an ongoing…

Neurons and Cognition · Quantitative Biology 2022-07-11 Yaqian Yang , Zhiming Zheng , Longzhao Liu , Hongwei Zheng , Yi Zhen , Yi Zheng , Xin Wang , Shaoting Tang

Synchronization plays a fundamental role in healthy cognitive and motor function. However, how synchronization depends on the interplay between local dynamics, coupling and topology and how prone to synchronization a network with given…

Neurons and Cognition · Quantitative Biology 2018-06-06 David Papo , Javier M. Buldú

Time Varying Functional Connectivity (TVFC) investigates how the interactions among brain regions vary over the course of an fMRI experiment. The transitions between different individual connectivity states can be modulated by changes in…

Large efforts are currently under way to systematically map functional connectivity between all pairs of millimeter-scale brain regions using big volumes of neuroimaging data. Functional magnetic resonance imaging (fMRI) can produce these…

Neurons and Cognition · Quantitative Biology 2014-09-24 Enzo Tagliazucchi , Helmut Laufs , Dante R. Chialvo

Non-invasive measurements of the human brain using magnetic resonance imaging (MRI) have significantly improved our understanding the brain's network organization by enabling measurement of anatomical connections between brain regions…

Applications · Statistics 2025-12-10 Keshav Motwani , Ali Shojaie , Ariel Rokem , Eardi Lila

Recently we developed a novel method for assessing the hierarchical modularity of functional brain networks - the probability associated community estimation(PACE). The PACE algorithm is unique in that it permits a dual formulation, thus…

Neurons and Cognition · Quantitative Biology 2018-01-08 Sean D. Conrin , Liang Zhan , Zachery D. Morrissey , Mengqi Xing , Angus Forbes , Pauline Maki , Mohammed R. Milad , Olusola Ajilore , Alex D. Leow

Directionality is a fundamental feature of network connections. Most structural brain networks are intrinsically directed because of the nature of chemical synapses, which comprise most neuronal connections. Due to limitations of…

Neurons and Cognition · Quantitative Biology 2018-01-19 Penelope Kale , Andrew Zalesky , Leonardo L. Gollo

Resting-state functional MRI (rsfMRI) yields functional connectomes that can serve as cognitive fingerprints of individuals. Connectomic fingerprints have proven useful in many machine learning tasks, such as predicting subject-specific…

Machine Learning · Computer Science 2020-08-10 Gia H. Ngo , Meenakshi Khosla , Keith Jamison , Amy Kuceyeski , Mert R. Sabuncu

Cognitive task classification using machine learning plays a central role in decoding brain states from neuroimaging data. By integrating machine learning with brain network analysis, complex connectivity patterns can be extracted from…

Machine Learning · Computer Science 2026-01-01 Debasis Maji , Arghya Banerjee , Debaditya Barman

The best approach to quantify human brain functional reconfigurations in response to varying cognitive demands remains an unresolved topic in network neuroscience. We propose that such functional reconfigurations may be categorized into…

Neurons and Cognition · Quantitative Biology 2020-11-09 Duy Duong-Tran , Kausar Abbas , Enrico Amico , Bernat Corominas-Murtra , Mario Dzemidzic , David Kareken , Mario Ventresca , Joaquín Goñi

Early brain development is characterized by the formation of a highly organized structural connectome. The interconnected nature of this connectome underlies the brain's cognitive abilities and influences its response to diseases and…

Neurons and Cognition · Quantitative Biology 2023-08-24 Yihan Wu , Lana Vasung , Camilo Calixto , Ali Gholipour , Davood Karimi

In the face of the stupefying complexity of the human brain, network analysis is a most useful tool that allows one to greatly simplify the problem, typically by approximating the billions of neurons comprising the brain by means of a…

Neurons and Cognition · Quantitative Biology 2023-10-03 Youssef Kora , Christoph Simon

In the literature of cognitive neuroscience, researchers tend to assume a linear relationship between brain activation level and task performance; however, controversial findings have been reported in participants at different ages and…

Neurons and Cognition · Quantitative Biology 2025-10-17 Fan Cao , Yuqi Yuan , Xiaohui Yan , Bohan Zhang , Kyle Perkins