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We propose a mathematical model for computing drug release from multi-layer capsules. The diffusion problem in such heterogeneous layer-by-layer composite medium is described by a system of coupled partial differential equations, which we…

Medical Physics · Physics 2017-08-04 Badr Kaoui , Marco Lauricella , Giuseppe Pontrelli

We present a mechanistic model of drug release from a multiple emulsion into an external surrounding fluid. We consider a single multi-layer droplet where the drug kinetics are described by a pure diffusive process through different liquid…

Soft Condensed Matter · Physics 2020-09-02 G. Pontrelli , E. J. Carr , A. Tiribocchi , S. Succi

The derivation of suitable analytical models is an important step for the design and analysis of molecular communication systems. However, many existing models have limited applicability in practical scenarios due to various simplifications…

Emerging Technologies · Computer Science 2019-11-28 Maximilian Schäfer , Wayan Wicke , Werner Haselmayr , Rudolf Rabenstein , Robert Schober

A consolidated mathematical formulation of the spherically symmetric mass-transfer problem is presented, with the quasi-stationary approximating equations derived from a perturbation point of view for the leading-order effect. For the…

Mathematical Physics · Physics 2012-09-24 James Q. Feng

Spherical multi-layered structures are prevalent in numerous biological systems and engineered applications, including tumor spheroids, layered tissues, and multi-shell nanoparticles for targeted drug delivery. Despite their widespread…

Information Theory · Computer Science 2025-03-19 Mitra Rezaei , Michael Chappell , Adam Noel

Predicting the release performance of a drug delivery device is an important challenge in pharmaceutics and biomedical science. In this paper, we consider a multi-layer diffusion model of drug release from a composite spherical microcapsule…

Medical Physics · Physics 2019-01-25 Elliot J. Carr , Giuseppe Pontrelli

The problem of diffusion in a porous medium with a spatially varying porosity is considered. The particular microstructure analyzed comprises a collection of impenetrable spheres, though the methods developed are general. Two different…

Fluid Dynamics · Physics 2017-10-12 Maria Bruna , S. Jonathan Chapman

In this work, a thermal energy transfer problem in a one-dimensional multilayer body is theoretically analyzed, considering diffusion, advection, internal heat generation or loss linearly dependent on temperature in each layer, as well as…

Fluid Dynamics · Physics 2025-01-16 Guillermo Federico Umbricht , Domingo Alberto Tarzia , Diana Rubio

One of the promising frontiers of bioengineering is the controlled release of a therapeuticdrug from a vehicle across the skin (transdermal drug delivery). In order to study the complete process, a two-phase mathematical model describing…

Quantitative Methods · Quantitative Biology 2016-01-15 Giuseppe Pontrelli , Filippo de Monte

In this paper we propose and validate a multiscale model for the description of particle diffusion in presence of trapping boundaries. We start from a drift-diffusion equation in which the drift term describes the effect of bubble traps,…

Numerical Analysis · Mathematics 2023-07-11 Clarissa Astuto , Antonio Raudino , Giovanni Russo

Local drug delivery has received much recognition in recent years, yet it is still unpredictable how drug efficacy depends on physicochemical properties and delivery kinetics. The purpose of the current study is to provide a useful…

Dynamical Systems · Mathematics 2016-01-26 Koyel Chakravarty , D C Dalal

We consider a random diffusion dynamics for an infinite system of hard spheres of two different sizes evolving in $\mathbb{R}^d$, its reversible probability measure, and its projection on the subset of the large spheres. The main feature is…

Probability · Mathematics 2024-03-05 Myriam Fradon , Julian Kern , Sylvie Roelly , Alexander Zass

In this paper we present a mathematical model for the electrochemical deposition aimed at the production of inverse opals. The real system consists of an arrangement of sub micrometer spheres, through which the species in an electrolytic…

Chemical Physics · Physics 2013-06-25 P. C. T. D'Ajello , L. Lauck , G. L. Nunes

We address the dynamics of adsorbed molecules (a fundamental issue in surface physics) within the framework of a Master Equation scheme, and study the diffusion of particles in a finite cubic lattice whose boundaries are at the $z=1$ and…

Statistical Mechanics · Physics 2009-11-10 Jorge A. Revelli , Carlos. E. Budde , Domingo Prato , Horacio S. Wio

Diffusion of a two component fluid is studied in the framework of differential equations, but where these equations are systematically derived from a well-defined microscopic model. The model has a finite carrying capacity imposed upon it…

Statistical Mechanics · Physics 2015-06-04 D. Fanelli , A. J. McKane , G. Pompili , B. Tiribilli , M. Vassalli , T. Biancalani

In this paper, diffusion in polymer solutions undergoing evaporation of solvent is modeled as a coupled heat and mass transfer problem with moving boundary condition within the framework of nonequilibrium thermodynamics. The proposed…

Chemical Physics · Physics 2012-04-13 Siamak. Shams Es-haghi

The self-diffusion process of a hard sphere fluid confined by two parallel plates separated by a distance on the order of the particle diameter is studied. The starting point is a closed kinetic equation for the distribution function that…

Statistical Mechanics · Physics 2025-10-24 Manuel Mayo , María Isabel García de Soria , Pablo Maynar , José Javier Brey

This work studies the parameter-dependent diffusion equation in a two-dimensional domain consisting of locally mirror symmetric layers. It is assumed that the diffusion coefficient is a constant in each layer. The goal is to find…

Numerical Analysis · Mathematics 2024-12-20 Antti Autio , Antti Hannukainen

Various substances in the liquid state tend to form droplets. In this paper the shape of such droplets is investigated within the spherical model of a lattice gas. We show that in this case the droplet boundary is always diffusive, as…

Statistical Mechanics · Physics 2015-05-20 Anatoly E. Patrick

Multilayer diffusion problems have found significant important that they arise in many medical, environmental and industrial applications of heat and mass transfer. In this article, we study the solvability of one-dimensional nonhomogeneous…

Analysis of PDEs · Mathematics 2021-09-15 Mohamed Akel , Hillal M. Elshehabey , Ragaa Ahmed
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