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The National Electrical Manufacturers Association's (NEMA) NU 4-2008 standard specifies methodology for evaluating the performance of small-animal PET scanners. The standard's goal is to enable comparison of different PET scanners over a…

Medical Physics · Physics 2020-03-03 Patrick Hallen , David Schug , Volkmar Schulz

Positron emission tomography (PET) is widely used in various clinical applications, including cancer diagnosis, heart disease and neuro disorders. The use of radioactive tracer in PET imaging raises concerns due to the risk of radiation…

Computer Vision and Pattern Recognition · Computer Science 2017-12-13 Junshen Xu , Enhao Gong , John Pauly , Greg Zaharchuk

On-chip waveguide sensors have attracted significant attention recently due to their potential for high level integration. However, so far on-chip gas sensing based on traditional laser absorption spectroscopy has demonstrated low detection…

An explicit positronium (Ps) source model was implemented in Geant4 to provide direct event-level control over annihilation channel selection, decay timing, and photon emission topology. The implementation supports direct annihilation,…

Medical Physics · Physics 2026-04-29 Jason G Parker

Carbon ion therapy have the ability to overcome the limitation of convertional radiotherapy due to its most energy deposition in selective depth, usually called Bragg peak, which results in increased biological effectiness. During carbon…

This study focuses on developing a self-triggered data acquisition system and a noise reduction algorithm for the Multi-gap Resistive Plate Chamber (MRPC) Time-of-Flight Positron Emission Tomography (TOF-PET) system. The system integrates a…

Instrumentation and Detectors · Physics 2025-05-13 Jianing Liu , Yuelei Ma , Ziyang Chen , Zhenyan Li , Yi Wang , Baohong Guo , Dong Han , Yuanjing Li

Positron Emission Tomography (PET) enables functional imaging of deep brain structures, but the bulk and weight of current systems preclude their use during many natural human activities, such as locomotion. The proposed long-term solution…

Robotics · Computer Science 2023-12-07 Junxiang Wang , Ti Wu , Iulian I. Iordachita , Peter Kazanzides

\textit{Topmetal-${II}^-$} is a low noise CMOS pixel direct charge sensor with a pitch of 83$\mu m$. CdZnTe is an excellent semiconductor material for radiation detection. The combination of CdZnTe and the sensor makes it possible to build…

Instrumentation and Detectors · Physics 2017-02-22 Shuguang Zou , Yan Fan , Xiangming Sun , Guangming Huang , Hua Pei , Zhen Wang , Jun Liu , Ping Yang , Dong Wang

Historically, patient datasets have been used to develop and validate various reconstruction algorithms for PET/MRI and PET/CT. To enable such algorithm development, without the need for acquiring hundreds of patient exams, in this paper we…

Low-dose Positron Emission Tomography (PET) imaging presents a significant challenge due to increased noise and reduced image quality, which can compromise its diagnostic accuracy and clinical utility. Denoising diffusion probabilistic…

Image and Video Processing · Electrical Eng. & Systems 2025-03-03 Boxiao Yu , Savas Ozdemir , Jiong Wu , Yizhou Chen , Ruogu Fang , Kuangyu Shi , Kuang Gong

Positron emission tomography (PET) is widely utilized for cancer detection due to its ability to visualize functional and biological processes in vivo. PET images are usually reconstructed from histogrammed raw data (sinograms) using…

Image and Video Processing · Electrical Eng. & Systems 2024-11-26 Yiran Sun , Osama Mawlawi

Visible photonic integrated circuits underpin applications ranging from AR/VR to quantum control, yet lack a high-resolution, nondestructive diagnostic comparable to the optical frequency-domain reflectometry used in infrared silicon…

The Jagiellonian Positron Emission Tomograph (J-PET) is the first PET built from plastic scintillators. J-PET prototype consists of 192 detection modules arranged axially in three layers forming a cylindrical diagnostic chamber with the…

We present a nuclear medical imaging technique, employing triple-gamma trajectory intersections from beta^+ - gamma coincidences, able to reach sub-millimeter spatial resolution in 3 dimensions with a reduced requirement of reconstructed…

Medical Physics · Physics 2014-02-18 C. Lang , D. Habs , K. Parodi , P. G. Thirolf

Positron emission tomography (PET) is an advanced medical imaging technique that plays a crucial role in non-invasive clinical diagnosis. However, while reducing radiation exposure through low-dose PET scans is beneficial for patient…

Computer Vision and Pattern Recognition · Computer Science 2024-07-02 Bin Huang , Xubiao Liu , Lei Fang , Qiegen Liu , Bingxuan Li

Accurate quantification in positron emission tomography (PET) is essential for accurate diagnostic results and effective treatment tracking. A major issue encountered in PET imaging is attenuation. Attenuation refers to the diminution of…

In living organisms the positron-electron annihilation (occurring during the PET imaging) proceeds in about 30% via creation of a metastable ortho-positronium atom. In the tissue, due to the pick-off and conversion processes, over 98% of…

Treatment planning systems at proton-therapy centres generally use X-ray computed tomography (CT) as primary imaging technique to infer the proton treatment doses to tumour and healthy tissues. However, proton stopping powers in the body,…

Positron Emission Tomography (PET) is an important clinical imaging tool but inevitably introduces radiation hazards to patients and healthcare providers. Reducing the tracer injection dose and eliminating the CT acquisition for attenuation…

Computer Vision and Pattern Recognition · Computer Science 2024-06-18 Tianqi Chen , Jun Hou , Yinchi Zhou , Huidong Xie , Xiongchao Chen , Qiong Liu , Xueqi Guo , Menghua Xia , James S. Duncan , Chi Liu , Bo Zhou

To accurately quantify in vivo radiotracer uptake using Positron Emission Tomography (PET) is a challenging task due to low signal-to-noise ratio (SNR) and poor spatial resolution of PET camera along with the finite image sampling…

Image and Video Processing · Electrical Eng. & Systems 2020-06-03 Mahbubunnabi Tamal