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A biomedical relation statement is commonly expressed in multiple sentences and consists of many concepts, including gene, disease, chemical, and mutation. To automatically extract information from biomedical literature, existing biomedical…

Computation and Language · Computer Science 2021-01-13 Po-Ting Lai , Zhiyong Lu

Retrieving gene functional networks from knowledge databases presents a challenge due to the mismatch between disease networks and subtype-specific variations. Current solutions, including statistical and deep learning methods, often fail…

Machine Learning · Computer Science 2025-02-25 Ziwei Yang , Zheng Chen , Xin Liu , Rikuto Kotoge , Peng Chen , Yasuko Matsubara , Yasushi Sakurai , Jimeng Sun

This paper presents a novel approach to accurately classify the hallmarks of cancer, which is a crucial task in cancer research. Our proposed method utilizes the Bidirectional Encoder Representations from Transformers (BERT) architecture,…

Computation and Language · Computer Science 2023-06-08 Sultan Zavrak , Seyhmus Yilmaz

The analysis of a protein-expression pattern from tissue microarray (TMA) data will not immediately give an answer on synergistic or antagonistic effects between the expression of the observed proteins. But contrary to apparent first…

Molecular Networks · Quantitative Biology 2018-03-07 H Buerger , F Boecker , J Packeisen , K Agelopoulos , K Poos , W Nadler , E Korsching

Accurately linking news articles to scientific research works is a critical component in a number of applications, such as measuring the social impact of a research work and detecting inaccuracies or distortions in science news. Although…

Information Retrieval · Computer Science 2021-07-15 Jun Wang , Bei Yu

We present a system that allows life-science researchers to search a linguistically annotated corpus of scientific texts using patterns over dependency graphs, as well as using patterns over token sequences and a powerful variant of boolean…

Computation and Language · Computer Science 2020-06-09 Hillel Taub-Tabib , Micah Shlain , Shoval Sadde , Dan Lahav , Matan Eyal , Yaara Cohen , Yoav Goldberg

Inductive link prediction -- where entities during training and inference stages can be different -- has been shown to be promising for completing continuously evolving knowledge graphs. Existing models of inductive reasoning mainly focus…

Machine Learning · Computer Science 2021-03-08 Jiajun Chen , Huarui He , Feng Wu , Jie Wang

Responsible for many complex human diseases including cancers, disrupted or abnormal gene interactions can be identified through their expression changes correlating with the progression of a disease. However, the examination of all…

Quantitative Methods · Quantitative Biology 2013-02-18 Salim Chowdhury , Yanjun Qi , Alex Stewart , Rachel Ostroff , Renqiang Min

We present BioRAGent, an interactive web-based retrieval-augmented generation (RAG) system for biomedical question answering. The system uses large language models (LLMs) for query expansion, snippet extraction, and answer generation while…

Computation and Language · Computer Science 2024-12-18 Samy Ateia , Udo Kruschwitz

Identifying interactions between proteins is important to understand underlying biological processes. Extracting a protein-protein interaction (PPI) from the raw text is often very difficult. Previous supervised learning methods have used…

Quantitative Methods · Quantitative Biology 2018-08-10 Mahtab Ahmed , Jumayel Islam , Muhammad Rifayat Samee , Robert E. Mercer

The exponential increase in publication rate of new articles is limiting access of researchers to relevant literature. This has prompted the use of text mining tools to extract key biological information. Previous studies have reported…

Information Retrieval · Computer Science 2007-08-07 Maurice HT Ling , Christophe Lefevre , Kevin R. Nicholas , Feng Lin

Document-level relation extraction (DocRE) is a task that focuses on identifying relations between entities within a document. However, existing DocRE models often overlook the correlation between relations and lack a quantitative analysis…

Information Retrieval · Computer Science 2023-10-23 Yusheng Huang , Zhouhan Lin

Motivation: Protein interactions are fundamental building blocks of biochemical reaction systems underlying cellular functions. The complexity and functionality of such systems emerge not from the protein interactions themselves but from…

Molecular Networks · Quantitative Biology 2011-06-15 Johannes Köster , Eli Zamir , Sven Rahmann

With the explosive growth of biomedical literature, designing automatic tools to extract information from the literature has great significance in biomedical research. Recently, transformer-based BERT models adapted to the biomedical domain…

Computation and Language · Computer Science 2020-11-03 Peng Su , K. Vijay-Shanker

Document-level relation extraction requires integrating information within and across multiple sentences of a document and capturing complex interactions between inter-sentence entities. However, effective aggregation of relevant…

Computation and Language · Computer Science 2020-07-29 Guoshun Nan , Zhijiang Guo , Ivan Sekulić , Wei Lu

Language model (LM) pretraining can learn various knowledge from text corpora, helping downstream tasks. However, existing methods such as BERT model a single document, and do not capture dependencies or knowledge that span across…

Computation and Language · Computer Science 2022-03-31 Michihiro Yasunaga , Jure Leskovec , Percy Liang

Learning representations for semantic relations is important for various tasks such as analogy detection, relational search, and relation classification. Although there have been several proposals for learning representations for individual…

Computation and Language · Computer Science 2015-05-04 Danushka Bollegala , Takanori Maehara , Ken-ichi Kawarabayashi

The objective of this research is to introduce a network specialized in predicting drugs that can be repurposed by investigating real-world evidence sources, such as clinical trials and biomedical literature. Specifically, it aims to…

Artificial Intelligence · Computer Science 2024-06-28 Ahmed Abdeen Hamed , Tamer E. Fandy

Specific protein-protein interactions are crucial in the cell, both to ensure the formation and stability of multi-protein complexes, and to enable signal transduction in various pathways. Functional interactions between proteins result in…

Biological Physics · Physics 2016-11-21 Anne-Florence Bitbol , Robert S. Dwyer , Lucy J. Colwell , Ned S. Wingreen

Recent advances in neural word embedding provide significant benefit to various information retrieval tasks. However as shown by recent studies, adapting the embedding models for the needs of IR tasks can bring considerable further…

Information Retrieval · Computer Science 2018-04-05 Navid Rekabsaz , Bhaskar Mitra , Mihai Lupu , Allan Hanbury