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Cryo-electron microscopy is a revolutionary technique that can provide 3D density maps at near-atomic resolution. However, map validation is still an open issue in the field. Despite several efforts from the community, it is possible to…

Biological Physics · Physics 2019-08-06 Sebastian Ortiz , Luka Stanisic , Boris A Rodriguez , Markus Rampp , Gerhard Hummer , Pilar Cossio

Single-particle cryo-electron microscopy (cryo-EM) is a leading technology to resolve the structure of molecules. Early in the process, the user detects potential particle images in the raw data. Typically, there are many false detections…

Image and Video Processing · Electrical Eng. & Systems 2023-03-08 Gili Weiss-Dicker , Amitay Eldar , Yoel Shkolinsky , Tamir Bendory

We consider an uncertain linear inverse problem as follows. Given observation $\omega=Ax_*+\zeta$ where $A\in {\bf R}^{m\times p}$ and $\zeta\in {\bf R}^{m}$ is observation noise, we want to recover unknown signal $x_*$, known to belong to…

Statistics Theory · Mathematics 2025-02-07 Yannis Bekri , Anatoli Juditsky , Arkadi Nemirovski

The relationship between mappings of sets and renormalization group transformations is established, and renormalization group invariants of such mappings are found. These results are valid both for continuous and discrete mappings and for…

Mathematical Physics · Physics 2007-05-23 Gennady N. Nikolaev

In the context of agent based modeling and network theory, we focus on the problem of recovering behavior-related choice information from origin-destination type data, a topic also known under the name of network tomography. As a basis for…

Physics and Society · Physics 2015-08-24 Tiziano Squartini , Enrico Ser-Giacomi , Diego Garlaschelli , George Judge

Understanding protein flexibility and its dynamic interactions with other molecules is essential for studying protein function. Although cryogenic electron microscopy(cryo-EM) provides an opportunity to observe macromolecular dynamics…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Bintao He , Yiran Cheng , Hongjia Li , Xiang Gao , Xin Gao , Fa Zhang , Renmin Han

We revisit the topic of common lines between projection images in single particle cryo-electron microscopy (cryo-EM). We derive a novel low-rank constraint on a certain $2n \times n$ matrix storing properly-scaled basis vectors for the…

Optimization and Control · Mathematics 2024-06-10 Tommi Muller , Adriana L. Duncan , Eric J. Verbeke , Joe Kileel

In Gaussian graphical model selection, noise-corrupted samples present significant challenges. It is known that even minimal amounts of noise can obscure the underlying structure, leading to fundamental identifiability issues. A recent line…

Machine Learning · Statistics 2024-05-09 Abrar Zahin , Rajasekhar Anguluri , Lalitha Sankar , Oliver Kosut , Gautam Dasarathy

Cryogenic electron microscopy (cryo-EM) provides a unique opportunity to study the structural heterogeneity of biomolecules. Being able to explain this heterogeneity with atomic models would help our understanding of their functional…

Low-rank matrix recovery problems involving high-dimensional and heterogeneous data appear in applications throughout statistics and machine learning. The contribution of this paper is to establish the fundamental limits of recovery for a…

Machine Learning · Statistics 2022-03-22 Joshua K. Behne , Galen Reeves

Packing and covering problems for metric spaces, and graphs in particular, are of essential interest in combinatorics and coding theory. They are formulated in terms of metric balls of vertices. We consider a new problem in graph theory…

Combinatorics · Mathematics 2011-10-25 Vladimir Levenshtein , Johannes Siemons

This paper considers the model problem of reconstructing an object from incomplete frequency samples. Consider a discrete-time signal $f \in \C^N$ and a randomly chosen set of frequencies $\Omega$ of mean size $\tau N$. Is it possible to…

Numerical Analysis · Mathematics 2007-05-23 Emmanuel Candes , Justin Romberg , Terence Tao

The population recovery problem is a basic problem in noisy unsupervised learning that has attracted significant research attention in recent years [WY12,DRWY12, MS13, BIMP13, LZ15,DST16]. A number of different variants of this problem have…

Data Structures and Algorithms · Computer Science 2017-03-07 Anindya De , Ryan O'Donnell , Rocco Servedio

We consider the problem of recovering linear image $Bx$ of a signal $x$ known to belong to a given convex compact set ${\cal X}$ from indirect observation $\omega=Ax+\xi$ of $x$ corrupted by random noise $\xi$ with finite covariance matrix.…

Statistics Theory · Mathematics 2019-03-19 Anatoli Juditsky , Arkadi Nemirovski

Characterising the noise of an airborne electromagnetic (AEM) system is critical in correctly imaging the earth's subsurface conductivity. Deterministic and probabilistic geophysical inversion algorithms require foreknowledge of the system…

Geophysics · Physics 2026-05-06 Tim Scarr , Anandaroop Ray , Ross C. Brodie

Motivated by the problem of determining the atomic structure of macromolecules using single-particle cryo-electron microscopy (cryo-EM), we study the sample and computational complexities of the sparse multi-reference alignment (MRA) model:…

Information Theory · Computer Science 2021-09-27 Tamir Bendory , Oscar Mickelin , Amit Singer

We introduce $Recursive~Jigsaw~Reconstruction$, a technique for analyzing reconstructed particle interactions in the presence of kinematic and combinatoric unknowns associated with unmeasured and indistinguishable particles, respectively.…

High Energy Physics - Phenomenology · Physics 2017-12-27 Paul Jackson , Christopher Rogan

This paper considers the problem of estimating an unknown high dimensional signal from noisy linear measurements, {when} the signal is assumed to possess a \emph{group-sparse} structure in a {known,} fixed dictionary. We consider signals…

Information Theory · Computer Science 2018-05-22 Mojtaba Kadkhodaie Elyaderani , Swayambhoo Jain , Jeffrey Druce , Stefano Gonella , Jarvis Haupt

Multi-reference alignment (MRA) is the problem of recovering a signal from its multiple noisy copies, each acted upon by a random group element. MRA is mainly motivated by single-particle cryo-electron microscopy (cryo-EM) that has recently…

Information Theory · Computer Science 2023-08-15 Tamir Bendory , Dan Edidin

We suggest a new algorithm to estimate representations of compact Lie groups from finite samples of their orbits. Different from other reported techniques, our method allows the retrieval of the precise representation type as a direct sum…

Optimization and Control · Mathematics 2025-09-23 Henrique Ennes , Raphaël Tinarrage