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We introduce a framework for recovering an image from its rotationally and translationally invariant features based on autocorrelation analysis. This work is an instance of the multi-target detection statistical model, which is mainly used…

Image and Video Processing · Electrical Eng. & Systems 2022-03-03 Nicholas F. Marshall , Ti-Yen Lan , Tamir Bendory , Amit Singer

Orbit recovery problems are a class of problems that often arise in practice and various forms. In these problems, we aim to estimate an unknown function after being distorted by a group action and observed via a known operator. Typically,…

Methodology · Statistics 2024-01-31 Yuehaw Khoo , Sounak Paul , Nir Sharon

In this work we study orbit recovery over $SO(3)$, where the goal is to recover a function on the sphere from noisy, randomly rotated copies of it. We assume that the function is a linear combination of low-degree spherical harmonics. This…

Data Structures and Algorithms · Computer Science 2022-05-03 Allen Liu , Ankur Moitra

The group synchronization problem involves estimating a collection of group elements from noisy measurements of their pairwise ratios. This task is a key component in many computational problems, including the molecular reconstruction…

Signal Processing · Electrical Eng. & Systems 2022-12-09 Noam Janco , Tamir Bendory

We study the recovery of an unknown three-dimensional band-limited signal from multiple noisy observations that are randomly rotated by latent elements of SO(3), where the rotations are drawn from an unknown, non-uniform distribution.…

Signal Processing · Electrical Eng. & Systems 2026-02-25 Tamir Bendory , Dan Edidin , Josh Katz , Shay Kreymer , Nir Sharon

Cryo-Electron Microscopy (Cryo-EM) is a Nobel prize-winning technology for determining the 3D structure of particles at near-atomic resolution. A fundamental step in the recovering of the 3D single-particle structure is to align its 2D…

Image and Video Processing · Electrical Eng. & Systems 2021-01-12 Koby Bibas , Gili Weiss-Dicker , Dana Cohen , Noa Cahan , Hayit Greenspan

Motivated by applications to equivariant neural networks and cryo-electron microscopy we consider the problem of recovering the generic orbit in a representation of a finite group from invariants of low degree. The main result proved here…

Representation Theory · Mathematics 2025-03-04 Dan Edidin , Josh Katz

Motivated by applications to single-particle cryo-electron microscopy (cryo-EM), we study several problems of function estimation in a high noise regime, where samples are observed after random rotation and possible linear projection of the…

Statistics Theory · Mathematics 2022-10-06 Zhou Fan , Roy R. Lederman , Yi Sun , Tianhao Wang , Sheng Xu

We study the orbit recovery problem under the rigid-motion group SE(n), where the objective is to reconstruct an unknown signal from multiple noisy observations subjected to unknown rotations and translations. This problem is fundamental in…

Information Theory · Computer Science 2025-12-09 Amnon Balanov , Tamir Bendory , Dan Edidin

Cryo-electron microscopy (Cryo-EM) enables high-resolution imaging of biomolecules, but structural heterogeneity remains a major challenge in 3D reconstruction. Traditional methods assume a discrete set of conformations, limiting their…

Machine Learning · Statistics 2025-09-09 Diego Sanchez Espinosa , Erik H Thiede , Yunan Yang

Determining the three-dimensional structure of proteins and protein complexes at atomic resolution is a fundamental task in structural biology. Over the last decade, remarkable progress has been made using "single particle" cryo-electron…

Numerical Analysis · Mathematics 2017-06-05 Alex Barnett , Leslie Greengard , Andras Pataki , Marina Spivak

We consider the problem of estimating a cloud of points from numerous noisy observations of that cloud after unknown rotations, and possibly reflections. This is an instance of the general problem of estimation under group action,…

Statistics Theory · Mathematics 2021-05-25 Thomas Pumir , Amit Singer , Nicolas Boumal

In single-particle cryo-electron microscopy (cryo-EM), the efficient determination of orientation parameters for 2D projection images poses a significant challenge yet is crucial for reconstructing 3D structures. This task is complicated by…

Image and Video Processing · Electrical Eng. & Systems 2025-09-30 Szu-Chi Chung

In recent years, an abundance of new molecular structures have been elucidated using cryo-electron microscopy (cryo-EM), largely due to advances in hardware technology and data processing techniques. Owing to these new exciting…

Information Theory · Computer Science 2020-04-22 Tamir Bendory , Alberto Bartesaghi , Amit Singer

Cryo-electron microscopy (cryo-EM) has become a tool of fundamental importance in structural biology, helping us understand the basic building blocks of life. The algorithmic challenge of cryo-EM is to jointly estimate the unknown 3D poses…

Computer Vision and Pattern Recognition · Computer Science 2022-09-01 Axel Levy , Frédéric Poitevin , Julien Martel , Youssef Nashed , Ariana Peck , Nina Miolane , Daniel Ratner , Mike Dunne , Gordon Wetzstein

We study the dihedral multi-reference alignment problem of estimating the orbit of a signal from multiple noisy observations of the signal, acted on by random elements of the dihedral group. We show that if the group elements are drawn from…

Information Theory · Computer Science 2022-01-05 Tamir Bendory , Dan Edidin , William Leeb , Nir Sharon

Single particle cryo-electron microscopy has become a critical tool in structural biology over the last decade, able to achieve atomic scale resolution in three dimensional models from hundreds of thousands of (noisy) two-dimensional…

Numerical Analysis · Mathematics 2023-07-19 Aaditya V. Rangan , Leslie Greengard

Determining the 3D structures of biological molecules is a key problem for both biology and medicine. Electron Cryomicroscopy (Cryo-EM) is a promising technique for structure estimation which relies heavily on computational methods to…

Machine Learning · Statistics 2015-01-29 Ali Punjani , Marcus A. Brubaker

We prove that low-rank matrices can be recovered efficiently from a small number of measurements that are sampled from orbits of a certain matrix group. As a special case, our theory makes statements about the phase retrieval problem. Here,…

Information Theory · Computer Science 2016-10-27 Richard Kueng , Huangjun Zhu , David Gross

The growing role of data-driven approaches to scientific discovery has unveiled a large class of models that involve latent transformations with a rigid algebraic constraint. Three-dimensional molecule reconstruction in Cryo-Electron…

Information Theory · Computer Science 2019-06-04 Amelia Perry , Jonathan Weed , Afonso S. Bandeira , Philippe Rigollet , Amit Singer
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