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Integrative modeling of macromolecular assemblies allows for structural characterization of large assemblies that are recalcitrant to direct experimental observation. A Bayesian inference approach facilitates combining data from…

Biomolecules · Quantitative Biology 2026-01-13 Shreyas Arvindekar , Kartik Majila , Shruthi Viswanath

Bayesian predictive probabilities are commonly used for interim monitoring of clinical trials through efficacy and futility stopping rules. Despite their usefulness, calculation of predictive probabilities, particularly in pre-experiment…

Applications · Statistics 2024-06-18 Joe Marion , Liz Lorenzi , Cora Allen-Savietta , Scott Berry , Kert Viele

Simulation-based inference has been popular for amortized Bayesian computation. It is typical to have more than one posterior approximation, from different inference algorithms, different architectures, or simply the randomness of…

Methodology · Statistics 2024-03-04 Yuling Yao , Bruno Régaldo-Saint Blancard , Justin Domke

Tasks such as social network analysis, human behavior recognition, or modeling biochemical reactions, can be solved elegantly by using the probabilistic inference framework. However, standard probabilistic inference algorithms work at a…

Artificial Intelligence · Computer Science 2018-12-11 Stefan Lüdtke , Max Schröder , Frank Krüger , Sebastian Bader , Thomas Kirste

A key challenge in spatial statistics is the analysis for massive spatially-referenced data sets. Such analyses often proceed from Gaussian process specifications that can produce rich and robust inference, but involve dense covariance…

Methodology · Statistics 2019-07-25 Shinichiro Shirota , Andrew O. Finley , Bruce D. Cook , Sudipto Banerjee

We present a Bayesian approach to machine learning with probabilistic programs. In our approach, training on available data is implemented as inference on a hierarchical model. The posterior distribution of model parameters is then used to…

Machine Learning · Computer Science 2022-01-19 David Tolpin

When expert systems based on causal probabilistic networks (CPNs) reach a certain size and complexity, the "combinatorial explosion monster" tends to be present. We propose an approximation scheme that identifies rarely occurring cases and…

Artificial Intelligence · Computer Science 2013-04-05 Frank Jensen , S. K. Anderson

The Bayesian approach to solving inverse problems relies on the choice of a prior. This critical ingredient allows the formulation of expert knowledge or physical constraints in a probabilistic fashion and plays an important role for the…

Machine Learning · Statistics 2022-11-08 Manuel Marschall , Gerd Wübbeler , Franko Schmähling , Clemens Elster

Prompt programming treats large language model prompts as software components with typed interfaces. Based on a literature survey of 15 recent works from 2023 to 2025, we observe a consistent trend: type systems are central to emerging…

Programming Languages · Computer Science 2025-08-19 Abhijit Paul

One approach for constructing copula functions is by multiplication. Given that products of cumulative distribution functions (CDFs) are also CDFs, an adjustment to this multiplication will result in a copula model, as discussed by…

Machine Learning · Statistics 2015-11-10 Ricardo Silva

The multi-resolution approximation (MRA) of Gaussian processes was recently proposed to conduct likelihood-based inference for massive spatial data sets. An advantage of the methodology is that it can be parallelized. We implemented the MRA…

Computation · Statistics 2019-05-07 Huang Huang , Lewis R. Blake , Dorit M. Hammerling

Until recently, the use of Bayesian inference in population genetics was limited to a few cases because for many realistic population genetic models the likelihood function cannot be calculated analytically . The situation changed with the…

Methodology · Statistics 2009-01-16 Christoph Leuenberger Daniel Wegmann Laurent Excoffier

Researchers have recently proposed several systems that ease the process of performing Bayesian probabilistic inference. These include systems for automatic inference algorithm synthesis as well as stronger abstractions for manual algorithm…

Programming Languages · Computer Science 2018-05-07 Eric Atkinson , Cambridge Yang , Michael Carbin

This article addresses the problem of efficient Bayesian inference in dynamic systems using particle methods and makes a number of contributions. First, we develop a correlated pseudo-marginal (CPM) approach for Bayesian inference in state…

Methodology · Statistics 2016-12-22 P. Choppala , D. Gunawan , J. Chen , M. -N. Tran , R. Kohn

We introduce the notion of a stochastic probabilistic program and present a reference implementation of a probabilistic programming facility supporting specification of stochastic probabilistic programs and inference in them. Stochastic…

Machine Learning · Statistics 2020-01-23 David Tolpin , Tomer Dobkin

We consider probabilistic programming for birth-death models of evolution and introduce a new widely-applicable inference method that combines an extension of the alive particle filter (APF) with automatic Rao-Blackwellization via delayed…

Computation · Statistics 2021-02-16 Jan Kudlicka , Lawrence M. Murray , Fredrik Ronquist , Thomas B. Schön

In recent years, empirical Bayesian (EB) inference has become an attractive approach for estimation in parametric models arising in a variety of real-life problems, especially in complex and high-dimensional scientific applications.…

Methodology · Statistics 2023-03-01 Hien D Nguyen , Mayetri Gupta

Probabilistic programming makes it easy to represent a probabilistic model as a program. Building an individual model, however, is only one step of probabilistic modeling. The broader challenge of probabilistic modeling is in understanding…

Programming Languages · Computer Science 2022-08-15 Ryan Bernstein

We consider the task of performing probabilistic inference with probabilistic logical models. Many algorithms for approximate inference with such models are based on sampling. From a logic programming perspective, sampling boils down to…

Artificial Intelligence · Computer Science 2015-03-19 Daan Fierens