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In the present study, we consider the Extra-Membrane-Intra model (EMI) for the simulation of excitable tissues at the cellular level. We provide the (possibly large) system of partial differential equations (PDEs), equipped with ad hoc…

Numerical Analysis · Mathematics 2024-09-23 Pietro Benedusi , Paola Ferrari , Marius Causemann , Stefano Serra-Capizzano

In this paper we consider a three-field formulation of the Biot model which has the displacement, the total pressure, and the pore pressure as unknowns. For parameter-robust stability analysis, we first show a priori estimates of the…

Numerical Analysis · Mathematics 2018-07-02 Jeonghun J. Lee

We present the meshfree Mixed Collocation Method (MCM) to solve the monodomain model for numerical simulation of cardiac electrophysiology. We apply MCM to simulate cardiac electrical propagation in 2D tissue sheets and 3D tissue slabs as…

Numerical Analysis · Mathematics 2021-10-14 Konstantinos A. Mountris , Esther Pueyo

Modeling cardiovascular blood flow is central to many applications in biomedical engineering. To accommodate the complexity of the cardiovascular system, in terms of boundary conditions and surrounding vascular tissue, computational fluid…

Fluid Dynamics · Physics 2024-12-05 Marc Hirschvogel , Mia Bonini , Maximilian Balmus , David Nordsletten

While ventricular electromechanics is extensively studied, four-chamber heart models have only been addressed recently; most of these works however neglect atrial contraction. Indeed, as atria are characterized by a complex physiology…

This paper considers an optimization problem for a dynamical system whose evolution depends on a collection of binary decision variables. We develop scalable approximation algorithms with provable suboptimality bounds to provide…

Optimization and Control · Mathematics 2016-10-31 Insoon Yang , Samuel A. Burden , Ram Rajagopal , S. Shankar Sastry , Claire J. Tomlin

Two novel parallel Newton-Krylov Balancing Domain Decomposition by Constraints (BDDC) and Dual-Primal Finite Element Tearing and Interconnecting (FETI-DP) solvers are here constructed, analyzed and tested numerically for implicit time…

Numerical Analysis · Mathematics 2022-04-21 Ngoc Mai Monica Huynh , Luca Franco Pavarino , Simone Scacchi

We present a two-level preconditioner for solving linear systems arising from the discretization of the elliptic, linear-elastic deformation equation, in displacement unknowns, over domains that have arbitrary geometric and topological…

Numerical Analysis · Mathematics 2025-09-25 Sabit Mahmood Khan , Yashar Mehmani

We study the homogenization of a novel microscopic tridomain system, allowing for a more detailed analysis of the properties of cardiac conduction than the classical bidomain and monodomain models. In (Acta Appl.Math. 179 (2022) 1--35), we…

Analysis of PDEs · Mathematics 2022-09-16 Fakhrielddine Bader , Mostafa Bendahmane , Mazen Saad , Raafat Talhouk

We present a robust and scalable preconditioner for the solution of large-scale linear systems that arise from the discretization of elliptic PDEs amenable to rank compression. The preconditioner is based on hierarchical low-rank…

Numerical Analysis · Mathematics 2017-12-27 Gustavo Chávez , George Turkiyyah , Stefano Zampini , David Keyes

The heart is a vital organ that relies on the orchestrated propagation of electrical stimuli to coordinate each heart beat. Abnormalities in the heart's electrical behaviour can be managed with a cardiac pacemaker. Recently, the closed-loop…

Systems and Control · Computer Science 2016-03-21 Eugene Yip , Sidharta Andalam , Partha S. Roop , Avinash Malik , Mark Trew , Weiwei Ai , Nitish Patel

In the present paper, a new three-scale asymptotic homogenization method is proposed to study the electrical behavior of the cardiac tissue structure with multiple heterogeneities at two different levels. The first level is associated with…

Analysis of PDEs · Mathematics 2022-01-11 Fakhrielddine Bader , Mostafa Bendahmane , Mazen Saad , Raafat Talhouk

Preconditioning has long been a staple technique in optimization, often applied to reduce the condition number of a matrix and speed up the convergence of algorithms. Although there are many popular preconditioning techniques in practice,…

Optimization and Control · Mathematics 2022-11-08 Zhaonan Qu , Wenzhi Gao , Oliver Hinder , Yinyu Ye , Zhengyuan Zhou

We consider here a cell-centered finite difference approximation of the Richards equation in three dimensions, averaging for interface values the hydraulic conductivity $K=K(p)$, a highly nonlinear function, by arithmetic, upstream, and…

Numerical Analysis · Mathematics 2022-07-18 Daniele Bertaccini , Pasqua D'Ambra , Fabio Durastante , Salvatore Filippone

We study a thermo-poroelasticity model which describes the interaction between the deformation of an elastic porous material and fluid flow under non-isothermal conditions. The model involves several parameters that can vary significantly…

Numerical Analysis · Mathematics 2025-12-24 Mingchao Cai , Miroslav Kuchta , Jingzhi Li , Ziliang Li , Kent-Andre Mardal

Clinical oriented applications of computational electrocardiology require efficient and reliable identification of patient-specific parameters of mathematical models based on available measures. In particular, the estimation of cardiac…

Numerical Analysis · Mathematics 2016-11-01 Huanhuan Yang , Alessandro Veneziani

We propose and analyse the properties of a new class of models for the electromechanics of cardiac tissue. The set of governing equations consists of nonlinear elasticity using a viscoelastic and orthotropic exponential constitutive law…

Numerical Analysis · Mathematics 2022-04-08 Adrienne Propp , Alessio Gizzi , Francesc Levrero-Florencio , Ricardo Ruiz-Baier

In this paper we study the linear systems arising from discretized poroelasticity problems. We formulate one block preconditioner for the two-filed Biot model and several preconditioners for the classical three-filed Biot model under the…

Numerical Analysis · Mathematics 2020-07-15 Shuangshuang Chen , Qingguo Hong , Jinchao Xu , Kai Yang

The forward problem in electrocardiology, computing body surface potentials from cardiac electrical activity, is traditionally solved using physics-based models such as the bidomain or monodomain equations. While accurate, these approaches…

Image and Video Processing · Electrical Eng. & Systems 2025-12-17 Shaheim Ogbomo-Harmitt , Cesare Magnetti , Chiara Spota , Jakub Grzelak , Oleg Aslanidi

We build a transient multidimensional multiphysical model based on continuum theories, involving the coupled mechanical, thermal and electrochemical phenomena occurring simultaneously in the discharge or charge of lithium-ion batteries. The…

Numerical Analysis · Mathematics 2024-03-26 Jaime Mora-Paz