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The numerical simulation of cardiac electrophysiology is a highly challenging problem in scientific computing. The Bidomain system is the most complete mathematical model of cardiac bioelectrical activity. It consists of an elliptic and a…

Numerical Analysis · Mathematics 2023-11-27 Edoardo Centofanti , Simone Scacchi

We prove the existence and the uniqueness of a solution for a modified bidomain model, describing the electrical behaviour of the cardiac tissue in pathological situations. The leading idea is to reduce the problem to an abstract parabolic…

Analysis of PDEs · Mathematics 2021-01-26 Micol Amar , Daniele Andreucci , Claudia Timofte

We provide a rather simple proof of a homogenization result for the bidomain model of cardiac electrophysiology. Departing from a microscopic cellular model, we apply the theory of two-scale convergence to derive the bidomain model. To…

Analysis of PDEs · Mathematics 2018-11-20 Erik Grandelius , Kenneth H. Karlsen

This work deals with the numerical solution of the monodomain and bidomain models of electrical activity of myocardial tissue. The bidomain model is a system consisting of a possibly degenerate parabolic PDE coupled with an elliptic PDE for…

Numerical Analysis · Mathematics 2008-07-03 Mostafa Bendahmane , Raimund Bürger , Ricardo Ruiz Baier

The numerical tools to simulate the bidomain model in cardiac electrophysiology are constantly developing due to the great clinical interest and scientific advances in mathematical models and computational power. The bidomain model consists…

Numerical Analysis · Mathematics 2025-11-03 Gopika P B , Peter Bastian , Nagaiah Chamakuri

We analyze a Balancing Domain Decomposition by Constraints (BDDC) preconditioner for the solution of three dimensional composite Discontinuous Galerkin discretizations of reaction-diffusion systems of ordinary and partial differential…

We consider the monodomain model, a system of a parabolic semilinear reaction-diffusion equation coupled with a nonlinear ordinary differential equation, arising from the (simplified) mathematical description of the electrical activity of…

Numerical Analysis · Mathematics 2024-12-20 Luca Ratti , Marco Verani

The monodomain model is widely used in in-silico cardiology to describe excitation propagation in the myocardium. Frequently, operator splitting is used to decouple the stiff reaction term and the diffusion term in the monodomain model so…

Numerical Analysis · Mathematics 2021-10-14 Konstantinos A Mountris , Esther Pueyo

We analyze a system of nonlinear stochastic partial differential equations (SPDEs) of mixed elliptic-parabolic type that models the propagation of electric signals and their effect on the deformation of cardiac tissue. The system governs…

Analysis of PDEs · Mathematics 2024-05-29 Mostafa Bendahmane , Kenneth H. Karlsen , Fatima Mroue

The bidomain system of degenerate reaction-diffusion equations is a well-established spatial model of electrical activity in cardiac tissue, with "reaction" linked to the cellular action potential and "diffusion" representing current flow…

Analysis of PDEs · Mathematics 2018-03-26 Mostafa Bendahmane , Kenneth H. Karlsen

Objective: The bidomain model and the finite element method are an established standard to mathematically describe cardiac electrophysiology, but are both suboptimal choices for fast and large-scale simulations due to high computational…

Computer-based simulations of non-invasive cardiac electrical outputs, such as electrocardiograms and body surface potential maps, usually entail severe computational costs due to the need of capturing fine-scale processes and to the…

Numerical Analysis · Mathematics 2023-08-09 Elena Zappon , Andrea Manzoni , Alfio Quarteroni

A reduced-order model based on Proper Orthogonal Decomposition (POD) is proposed for the bidomain equations of cardiac electrophysiology. Its accuracy is assessed through electrocardiograms in various configurations, including myocardium…

Numerical Analysis · Mathematics 2012-07-23 Muriel Boulakia , Elisa Schenone , Jean-Frédéric Gerbeau

This article reviews the mechanical bidomain model, a mathematical description how the extracellular matrix and intracellular cytoskeleton are coupled by integrin proteins. The fundamental hypothesis is that differences between…

Biological Physics · Physics 2016-11-28 Bradley J. Roth

We study, by means of the periodic unfolding technique, the homogenization of a modified bidomain model, which describes the propagation of the action potential in the cardiac electrophysiology. Such a model, allowing the presence of…

Analysis of PDEs · Mathematics 2021-01-25 Micol Amar , Daniele Andreucci , Claudia Timofte

In this paper, we consider the monodomain model of cardiac electrophysiology. After an analysis of the well-posedness of the forward problem, we show that perfectly insulating regions (modeling ischemic regions in the cardiac tissue) can be…

Analysis of PDEs · Mathematics 2024-07-15 Andrea Aspri , Elena Beretta , Elisa Francini , Dario Pierotti , Sergio Vessella

Biot's consolidation model in poroelasticity has a number of applications in science, medicine, and engineering. The model depends on various parameters, and in practical applications these parameters ranges over several orders of…

Numerical Analysis · Mathematics 2016-06-22 Jeonghun J. Lee , Kent-Andre Mardal , Ragnar Winther

In this work, we provide a performance comparison between the Balancing Domain Decomposition by Constraints (BDDC) and the Algebraic Multigrid (AMG) preconditioners for cardiac mechanics on both structured and unstructured finite element…

Numerical Analysis · Mathematics 2022-08-15 Nicolás A. Barnafi , Luca F. Pavarino , Simone Scacchi

This paper combines the use of high order finite element methods with parallel preconditioners of domain decomposition type for solving electromagnetic problems arising from brain microwave imaging. The numerical algorithms involved in such…

Computational Physics · Physics 2020-03-23 M. Bonazzoli , V. Dolean , F. Rapetti , P. -H. Tournier

In this paper, we are dealing with a rigorous homogenization result at two different levels for the bidomain model of cardiac electro-physiology. The first level associated with the mesoscopic structure such that the cardiac tissue consists…

Analysis of PDEs · Mathematics 2022-01-12 Fakhrielddine Bader , Mostafa Bendahmane , Mazen Saad , Raafat Talhouk
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