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Fluorescence Lifetime Imaging (FLI) is a critical molecular imaging modality that provides unique information about the tissue microenvironment, which is invaluable for biomedical applications. FLI operates by acquiring and analyzing photon…

Image and Video Processing · Electrical Eng. & Systems 2024-12-06 Ismail Erbas , Vikas Pandey , Navid Ibtehaj Nizam , Nanxue Yuan , Amit Verma , Margarida Barosso , Xavier Intes

Fluorescence lifetime imaging (FLI) has been receiving increased attention in recent years as a powerful diagnostic technique in biological and medical research. However, existing FLI systems often suffer from a tradeoff between processing…

Image and Video Processing · Electrical Eng. & Systems 2025-11-10 Yang Lin , Paul Mos , Andrei Ardelean , Claudio Bruschini , Edoardo Charbon

Fluorescence lifetime imaging microscopy (FLIM) is a powerful quantitative technique that provides metabolic and molecular contrast, offering strong translational potential for label-free, real-time diagnostics. However, its clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-12-19 Paloma Casteleiro Costa , Parnian Ghapandar Kashani , Xuhui Liu , Alexander Chen , Ary Portes , Julien Bec , Laura Marcu , Aydogan Ozcan

Fluorescence lifetime imaging (FLI) is an important technique for studying cellular environments and molecular interactions, but its real-time application is limited by slow data acquisition, which requires capturing large time-resolved…

Image and Video Processing · Electrical Eng. & Systems 2024-10-03 Ismail Erbas , Vikas Pandey , Aporva Amarnath , Naigang Wang , Karthik Swaminathan , Stefan T. Radev , Xavier Intes

This paper reported a bespoke adder-based deep learning network for time-domain fluorescence lifetime imaging (FLIM). By leveraging the l1-norm extraction method, we propose a 1-D Fluorescence Lifetime AdderNet (FLAN) without…

Signal Processing · Electrical Eng. & Systems 2022-09-13 Zhenya Zang , Dong Xiao , Quan Wang , Ziao Jiao , Chen Yu , David Day-Uei Li

Fluorescence lifetime imaging microscopy (FLIM) systems are limited by their slow processing speed, low signal-to-noise ratio (SNR), and expensive and challenging hardware setups. In this work, we demonstrate applying a denoising…

Image and Video Processing · Electrical Eng. & Systems 2021-06-09 Varun Mannam , Yide Zhang , Xiaotong Yuan , Takashi Hato , Pierre C. Dagher , Evan L. Nichols , Cody J. Smith , Kenneth W. Dunn , Scott Howard

Fluorescence lifetime imaging microscopy (FLIM) is a powerful technique in biomedical research that uses the fluorophore decay rate to provide additional contrast in fluorescence microscopy. However, at present, the calculation, analysis,…

Image and Video Processing · Electrical Eng. & Systems 2021-06-09 Varun Mannam , Yide Zhang , Xiaotong Yuan , Cara Ravasio , Scott S. Howard

Super-resolution fluorescence microscopy, with a resolution beyond the diffraction limit of light, has become an indispensable tool to directly visualize biological structures in living cells at a nanometer-scale resolution. Despite…

Computer Vision and Pattern Recognition · Computer Science 2018-09-05 Yu Li , Fan Xu , Fa Zhang , Pingyong Xu , Mingshu Zhang , Ming Fan , Lihua Li , Xin Gao , Renmin Han

The mathematical theory of compressed sensing (CS) asserts that one can acquire signals from measurements whose rate is much lower than the total bandwidth. Whereas the CS theory is now well developed, challenges concerning hardware…

Fluorescence lifetime imaging (FLI) is a widely used technique in the biomedical field for measuring the decay times of fluorescent molecules, providing insights into metabolic states, protein interactions, and ligand-receptor bindings.…

We present a fast and accurate analytical method for fluorescence lifetime imaging microscopy (FLIM) using the extreme learning machine (ELM). We used extensive metrics to evaluate ELM and existing algorithms. First, we compared these…

Biological Physics · Physics 2022-03-28 Zhenya Zang , Dong Xiao , Quan Wang , Zinuo Li , Wujun Xie , Yu Chen , David Day Uei Li

Fluorescence lifetime imaging microscopy (FLIM) provides detailed information about molecular interactions and biological processes. A major bottleneck for FLIM is image resolution at high acquisition speeds, due to the engineering and…

Image and Video Processing · Electrical Eng. & Systems 2024-04-23 Valentin Kapitány , Areeba Fatima , Vytautas Zickus , Jamie Whitelaw , Ewan McGhee , Robert Insall , Laura Machesky , Daniele Faccio

Dynamic Magnetic Resonance Imaging (MRI) is a crucial non-invasive method used to capture the movement of internal organs and tissues, making it a key tool for medical diagnosis. However, dynamic MRI faces a major challenge: long…

Image and Video Processing · Electrical Eng. & Systems 2024-09-20 Tamir Shor , Chaim Baskin , Alex Bronstein

To improve the compressive sensing MRI (CS-MRI) approaches in terms of fine structure loss under high acceleration factors, we have proposed an iterative feature refinement model (IFR-CS), equipped with fixed transforms, to restore the…

Machine Learning · Computer Science 2019-09-26 Yiling Liu , Qiegen Liu , Minghui Zhang , Qingxin Yang , Shanshan Wang , Dong Liang

Magnetic resonance imaging (MRI) has revolutionized medical imaging, providing a non-invasive and highly detailed look into the human body. However, the long acquisition times of MRI present challenges, causing patient discomfort, motion…

Medical Physics · Physics 2026-01-16 Mojtaba Safari , Zach Eidex , Chih-Wei Chang , Richard L. J. Qiu , Xiaofeng Yang

Recently, deep learning-based compressive imaging (DCI) has surpassed the conventional compressive imaging in reconstruction quality and faster running time. While multi-scale has shown superior performance over single-scale, research in…

Image and Video Processing · Electrical Eng. & Systems 2020-08-04 Thuong Nguyen Canh , Byeungwoo Jeon

Fast Magnetic Resonance Imaging (MRI) is highly in demand for many clinical applications in order to reduce the scanning cost and improve the patient experience. This can also potentially increase the image quality by reducing the motion…

Computer Vision and Pattern Recognition · Computer Science 2017-05-23 Simiao Yu , Hao Dong , Guang Yang , Greg Slabaugh , Pier Luigi Dragotti , Xujiong Ye , Fangde Liu , Simon Arridge , Jennifer Keegan , David Firmin , Yike Guo

The mathematical theory of compressed sensing (CS) asserts that one can acquire signals from measurements whose rate is much lower than the total bandwidth. Whereas the CS theory is now well developed, challenges concerning hardware…

Information Theory · Computer Science 2013-07-18 Makhlad Chahid , Jerome Bobin , Hamed Shams Mousavi , Emmanuel Candes , Maxime Dahan , Vincent Studer

Deep Learning (DL) based Compressed Sensing (CS) has been applied for better performance of image reconstruction than traditional CS methods. However, most existing DL methods utilize the block-by-block measurement and each measurement…

Image and Video Processing · Electrical Eng. & Systems 2022-09-29 Zhifeng Wang , Zhenghui Wang , Chunyan Zeng , Yan Yu , Xiangkui Wan

Live-cell imaging of multiple subcellular structures is essential for understanding subcellular dynamics. However, the conventional multi-color sequential fluorescence microscopy suffers from significant imaging delays and limited number of…

Subcellular Processes · Quantitative Biology 2025-01-13 Mingyang Chen , Luhong Jin , Xuwei Xuan , Defu Yang , Yun Cheng , Ju Zhang
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