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We propose EBLIME to explain black-box machine learning models and obtain the distribution of feature importance using Bayesian ridge regression models. We provide mathematical expressions of the Bayesian framework and theoretical outcomes…

Machine Learning · Statistics 2023-05-02 Yuhao Zhong , Anirban Bhattacharya , Satish Bukkapatnam

Motivated by an open problem of validating protein identities in label-free shotgun proteomics work-flows, we present a testing procedure to validate class/protein labels using available measurements across instances/peptides. More…

Methodology · Statistics 2020-06-05 Melissa C. Key , Ben Boukai

Learning from preference labels plays a crucial role in fine-tuning large language models. There are several distinct approaches for preference fine-tuning, including supervised learning, on-policy reinforcement learning (RL), and…

Proteins perform critical processes in all living systems: converting solar energy into chemical energy, replicating DNA, as the basis of highly performant materials, sensing and much more. While an incredible range of functionality has…

Biomolecules · Quantitative Biology 2021-09-29 Leonardo V. Castorina , Rokas Petrenas , Kartic Subr , Christopher W. Wood

described by multiple instances (e.g., image patches) and simultaneously associated with multiple labels. Existing MIML methods are useful in many applications but most of which suffer from relatively low accuracy and training efficiency…

Computer Vision and Pattern Recognition · Computer Science 2023-06-16 Qi Lai , Jianhang Zhou , Yanfen Gan , Chi-Man Vong , Deshuang Huang

Large language models (LLMs) have garnered considerable attention for their proficiency in tackling intricate tasks, particularly leveraging their capacities for zero-shot and in-context learning. However, their utility has been…

Biomolecules · Quantitative Biology 2024-05-14 Yiqing Shen , Outongyi Lv , Houying Zhu , Yu Guang Wang

Research scientists increasingly rely on implementing software to support their research. While previous research has examined the impact of identifier names on program comprehension in traditional programming environments, limited work has…

Software Engineering · Computer Science 2025-07-23 Gunnar Larsen , Carol Wong , Anthony Peruma

Language identification is a crucial first step in multilingual systems such as chatbots and virtual assistants, enabling linguistically and culturally accurate user experiences. Errors at this stage can cascade into downstream failures,…

Accurate estimates of item difficulty are essential for valid assessment and effective adaptive learning. However, for newly created tasks, response data are typically unavailable. Pretesting and expert judgement can be costly and slow,…

The whole slide image (WSI) classification is often formulated as a multiple instance learning (MIL) problem. Since the positive tissue is only a small fraction of the gigapixel WSI, existing MIL methods intuitively focus on identifying…

Computer Vision and Pattern Recognition · Computer Science 2023-12-22 Wenhao Tang , Sheng Huang , Xiaoxian Zhang , Fengtao Zhou , Yi Zhang , Bo Liu

Python has become the programming language of choice for research and industry projects related to data science, machine learning, and deep learning. Since optimization is an inherent part of these research fields, more optimization related…

Neural and Evolutionary Computing · Computer Science 2020-05-25 Julian Blank , Kalyanmoy Deb

The capability of accurate prediction of protein functions and properties is essential in the biotechnology industry, e.g. drug development and artificial protein synthesis, etc. The main challenges of protein function prediction are the…

Quantitative Methods · Quantitative Biology 2021-12-02 Wei-Cheng Tseng , Po-Han Chi , Jia-Hua Wu , Min Sun

Instance segmentation of neurons in volumetric light microscopy images of nervous systems enables groundbreaking research in neuroscience by facilitating joint functional and morphological analyses of neural circuits at cellular resolution.…

Computer Vision and Pattern Recognition · Computer Science 2024-04-02 Lisa Mais , Peter Hirsch , Claire Managan , Ramya Kandarpa , Josef Lorenz Rumberger , Annika Reinke , Lena Maier-Hein , Gudrun Ihrke , Dagmar Kainmueller

This study investigates the current landscape and future directions of protein foundation model research. While recent advancements have transformed protein science and engineering, the field lacks a comprehensive benchmark for fair…

Biomolecules · Quantitative Biology 2025-06-19 Zhangyang Gao , Hao Wang , Cheng Tan , Chenrui Xu , Mengdi Liu , Bozhen Hu , Linlin Chao , Xiaoming Zhang , Stan Z. Li

Reasoning is central to a wide range of intellectual activities, and while the capabilities of large language models (LLMs) continue to advance, their performance in reasoning tasks remains limited. The processes and mechanisms underlying…

Artificial Intelligence · Computer Science 2024-10-07 Ippei Fujisawa , Sensho Nobe , Hiroki Seto , Rina Onda , Yoshiaki Uchida , Hiroki Ikoma , Pei-Chun Chien , Ryota Kanai

Biomarker detection is an indispensable part of the diagnosis and treatment of low-grade glioma (LGG). However, current LGG biomarker detection methods rely on expensive and complex molecular genetic testing, for which professionals are…

Image and Video Processing · Electrical Eng. & Systems 2026-04-21 Zijie Fang , Yihan Liu , Yifeng Wang , Xiangyang Zhang , Yang Chen , Changjing Cai , Yiyang Lin , Ying Han , Zhi Wang , Shan Zeng , Jun Tan , Yongbing Zhang , Hong Shen

Recently neural networks and multiple instance learning are both attractive topics in Artificial Intelligence related research fields. Deep neural networks have achieved great success in supervised learning problems, and multiple instance…

Machine Learning · Statistics 2020-04-08 Xinggang Wang , Yongluan Yan , Peng Tang , Xiang Bai , Wenyu Liu

The LLM Agent, equipped with a code interpreter, is capable of automatically solving real-world coding tasks, such as data analysis and image editing. However, existing benchmarks primarily focus on either simplistic tasks, such as…

Software Engineering · Computer Science 2024-08-06 Yaolun Zhang , Yinxu Pan , Yudong Wang , Jie Cai

Large Language Model (LLM) leaderboards based on benchmark rankings are regularly used to guide practitioners in model selection. Often, the published leaderboard rankings are taken at face value - we show this is a (potentially costly)…

Leveraging multiple training datasets to scale up image segmentation models is beneficial for increasing robustness and semantic understanding. Individual datasets have well-defined ground truth with non-overlapping mask layouts and…

Computer Vision and Pattern Recognition · Computer Science 2024-09-17 Qilong Zhangli , Di Liu , Abhishek Aich , Dimitris Metaxas , Samuel Schulter