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The field of machine learning for drug discovery is witnessing an explosion of novel methods. These methods are often benchmarked on simple physicochemical properties such as solubility or general druglikeness, which can be readily…

Various applications in different fields, such as gene expression analysis or computer vision, suffer from data sets with high-dimensional low-sample-size (HDLSS), which has posed significant challenges for standard statistical and modern…

Machine Learning · Computer Science 2021-01-27 Qingbo Yin , Ehsan Adeli , Liran Shen , Dinggang Shen

Large Language models (LLMs) have emerged as powerful tools for addressing challenges across diverse domains. Notably, recent studies have demonstrated that large language models significantly enhance the efficiency of biomolecular analysis…

Computation and Language · Computer Science 2025-03-07 Jiyue Jiang , Zikang Wang , Yuheng Shan , Heyan Chai , Jiayi Li , Zixian Ma , Xinrui Zhang , Yu Li

Existing feature engineering methods based on large language models (LLMs) have not yet been applied to multi-label learning tasks. They lack the ability to model complex label dependencies and are not specifically adapted to the…

Machine Learning · Computer Science 2025-12-18 Wanfu Gao , Zebin He , Jun Gao

While large multimodal models (LMMs) have achieved remarkable progress, generating pixel-level masks for image reasoning tasks involving multiple open-world targets remains a challenge. To bridge this gap, we introduce PixelLM, an effective…

Computer Vision and Pattern Recognition · Computer Science 2024-07-19 Zhongwei Ren , Zhicheng Huang , Yunchao Wei , Yao Zhao , Dongmei Fu , Jiashi Feng , Xiaojie Jin

The multiple-biomarker classifier problem and its assessment are reviewed against the background of some fundamental principles from the field of statistical pattern recognition, machine learning, or the recently so-called "data science". A…

Genomics · Quantitative Biology 2019-11-01 Waleed A. Yousef

The ability to follow instructions is crucial for Large Language Models (LLMs) to handle various real-world applications. Existing benchmarks primarily focus on evaluating pure response quality, rather than assessing whether the response…

Computation and Language · Computer Science 2024-06-06 Yuxin Jiang , Yufei Wang , Xingshan Zeng , Wanjun Zhong , Liangyou Li , Fei Mi , Lifeng Shang , Xin Jiang , Qun Liu , Wei Wang

Multiple Instance Learning (MIL) is a weakly-supervised problem in which one label is assigned to the whole bag of instances. An important class of MIL models is instance-based, where we first classify instances and then aggregate those…

Image and Video Processing · Electrical Eng. & Systems 2024-03-13 Łukasz Struski , Dawid Rymarczyk , Arkadiusz Lewicki , Robert Sabiniewicz , Jacek Tabor , Bartosz Zieliński

Multi-label classification deals with the problem where each instance is associated with multiple class labels. Because evaluation in multi-label classification is more complicated than single-label setting, a number of performance measures…

Machine Learning · Computer Science 2020-07-07 Xi-Zhu Wu , Zhi-Hua Zhou

The identification of essential proteins in protein-protein interaction networks (PINs) can help to discover drug targets and prevent disease. In order to improve the accuracy of the identification of essential proteins, researchers…

Molecular Networks · Quantitative Biology 2023-12-08 Haoyue Wang , Li Pan , Bo Yang , Junqiang Jiang , Wenbin Li

Instance segmentation is an important task for biomedical and biological image analysis. Due to the complicated background components, the high variability of object appearances, numerous overlapping objects, and ambiguous object…

Computer Vision and Pattern Recognition · Computer Science 2021-02-24 Dongnan Liu , Donghao Zhang , Yang Song , Heng Huang , Weidong Cai

Protein-specific large language models (Protein LLMs) are revolutionizing protein science by enabling more efficient protein structure prediction, function annotation, and design. While existing surveys focus on specific aspects or…

Timely and accurate lymphoma diagnosis is essential for guiding cancer treatment. Standard diagnostic practice combines hematoxylin and eosin (HE)-stained whole slide images with immunohistochemistry, flow cytometry, and molecular genetic…

Multiple kernel learning (MKL) algorithms combine different base kernels to obtain a more efficient representation in the feature space. Focusing on discriminative tasks, MKL has been used successfully for feature selection and finding the…

Machine Learning · Computer Science 2019-03-14 Babak Hosseini , Barbara Hammer

Detecting microbial biomarkers used to predict disease phenotypes and clinical outcomes is crucial for disease early-stage screening and diagnosis. Most methods for biomarker identification are linear-based, which is very limited as…

Quantitative Methods · Quantitative Biology 2021-09-29 Jian Jiang

Learning from Label Proportions (LLP) is an established machine learning problem with numerous real-world applications. In this setting, data items are grouped into bags, and the goal is to learn individual item labels, knowing only the…

Machine Learning · Computer Science 2023-10-31 Gabriel Franco , Giovanni Comarela , Mark Crovella

In-Context Learning (ICL) empowers Large Language Models (LLMs) for rapid task adaptation without Fine-Tuning (FT), but its reliance on demonstration selection remains a critical challenge. While many-shot ICL shows promising performance…

Computation and Language · Computer Science 2025-06-06 Jianfei Zhang , Bei Li , Jun Bai , Rumei Li , Yanmeng Wang , Chenghua Lin , Wenge Rong

Large language models (LLMs) are a class of artificial intelligence models based on deep learning, which have great performance in various tasks, especially in natural language processing (NLP). Large language models typically consist of…

Quantitative Methods · Quantitative Biology 2025-02-04 Jiajia Liu , Mengyuan Yang , Yankai Yu , Haixia Xu , Tiangang Wang , Kang Li , Xiaobo Zhou

Efficient benchmarking techniques aim to lower the computational cost of evaluating LLMs by predicting full benchmark scores using only a subset of a benchmark's questions. By reframing this problem as an instance of multiple regression…

Machine Learning · Statistics 2026-05-26 Sam Bowyer , Acyr Locatelli , Kris Cao

Weakly supervised machine learning algorithms are able to learn from ambiguous samples or labels, e.g., multi-instance learning or partial-label learning. However, in some real-world tasks, each training sample is associated with not only…

Machine Learning · Computer Science 2022-12-20 Wei Tang , Weijia Zhang , Min-Ling Zhang