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Prediction of node and graph labels are prominent network science tasks. Data analyzed in these tasks are sometimes related: entities represented by nodes in a higher-level (higher-scale) network can themselves be modeled as networks at a…

Molecular Networks · Quantitative Biology 2021-05-27 Shawn Gu , Meng Jiang , Pietro Hiram Guzzi , Tijana Milenkovic

Graph neural networks (GNNs) are increasingly used to model biological systems, yet the reliability of post-hoc explanation methods for recovering meaningful molecular mechanisms remains unclear. Here, we systematically evaluate four widely…

Molecular Networks · Quantitative Biology 2026-05-22 Kyle Higgins , Ivan Laponogov , Dennis Veselkov , Kirill Veselkov

In many organisms the expression levels of each gene are controlled by the activation levels of known "Transcription Factors" (TF). A problem of considerable interest is that of estimating the "Transcription Regulation Networks" (TRN)…

Applications · Statistics 2010-11-09 Gareth M. James , Chiara Sabatti , Nengfeng Zhou , Ji Zhu

Recurrent Neural Networks (RNNs) have achieved tremendous success in processing sequential data, yet understanding and analyzing their behaviours remains a significant challenge. To this end, many efforts have been made to extract finite…

Computation and Language · Computer Science 2023-06-27 Zeming Wei , Xiyue Zhang , Yihao Zhang , Meng Sun

Prediction deviations of different uncertainties have varying impacts on downstream decision-making. Improving the prediction accuracy of critical uncertainties with significant impacts on decision-making quality yields better optimization…

Systems and Control · Electrical Eng. & Systems 2025-10-17 Yingrui Zhuang , Lin Cheng , Can Wan , Rui Xie , Ning Qi , Yue Chen

Datacenter network design plays a critical role in AI training by supporting scaling to thousands of accelerators. An open problem, designing a near-optimal throughput oriented network-topology, routing, and collectives-has not been…

Networking and Internet Architecture · Computer Science 2026-05-28 Conor James Green , Mithuna Thottethodi

Cellular phenotypes are determined by the dynamical activity of networks of co-regulated genes. Elucidating such networks is crucial for the understanding of normal cell physiology as well as for the dissection of complex pathologic…

Molecular Networks · Quantitative Biology 2007-05-23 Kai Wang , Nilanjana Banerjee , Adam Margolin , Ilya Nemenman , Katia Basso , Riccardo Favera , Andrea Califano

Power system operators are increasingly deploying Grid Enhancing Technologies (GETs) to mitigate operational challenges such as line and transformer congestion, and voltage violations. These technologies, including Network Topology…

Systems and Control · Electrical Eng. & Systems 2026-02-24 Junseon Park , Hyeongon Park , Rahul K. Gupta

Recent advances in computational methods for intractable models have made network data increasingly amenable to statistical analysis. Exponential random graph models (ERGMs) emerged as one of the main families of models capable of capturing…

Computation · Statistics 2021-04-07 Alberto Caimo , Lampros Bouranis , Robert Krause , Nial Friel

Biological systems are driven by intricate interactions among the complex array of molecules that comprise the cell. Many methods have been developed to reconstruct network models of those interactions. These methods often draw on large…

Molecular Networks · Quantitative Biology 2018-06-29 Marieke Lydia Kuijjer , Matthew Tung , GuoCheng Yuan , John Quackenbush , Kimberly Glass

Methods for time series prediction and classification of gene regulatory networks (GRNs) from gene expression data have been treated separately so far. The recent emergence of attention-based recurrent neural networks (RNN) models boosted…

Misclassified binary outcome or mediator variables can cause unpredictable bias in resulting parameter estimates. As more datasets that were not originally collected for research purposes are being used for studies in the social and health…

Computation · Statistics 2025-01-15 Kimberly A. Hochstedler Webb , Martin T. Wells

Systematic variation is a common issue in metabolomics data analysis. Therefore, different scaling and normalization techniques are used to preprocess the data for metabolomics data analysis. Although several scaling methods are available…

Machine Learning · Statistics 2022-08-02 Biplab Biswas , Nishith Kumar , Md Aminul Hoque , Md Ashad Alam

Neuro-encoded expression programming(NEEP) that aims to offer a novel continuous representation of combinatorial encoding for genetic programming methods is proposed in this paper. Genetic programming with linear representation uses…

Neural and Evolutionary Computing · Computer Science 2021-04-12 Aftab Anjum , Fengyang Sun , Lin Wang , Jeff Orchard

Many complex systems in nature and society can be described in terms of networks capturing the intricate web of connections among the units they are made of. A key question is how to interpret the global organization of such networks as the…

Physics and Society · Physics 2007-05-23 Gergely Palla , Imre Derenyi , Illes Farkas , Tamas Vicsek

The cgam package contains routines to fit the generalized additive model where the components may be modeled with shape and smoothness assumptions. The main routine is cgam and nineteen symbolic routines are provided to indicate the…

Applications · Statistics 2018-12-20 Xiyue Liao , Mary C. Meyer

The statistical analysis of the structure of bipartite ecological networks has increased in importance in recent years. Yet, both algorithms and software packages for the analysis of network structure focus on properties of unipartite…

Quantitative Methods · Quantitative Biology 2014-07-18 Cesar O. Flores , Timothée Poisot , Sergi Valverde , Joshua S. Weitz

We present RKappa, a framework for the development and analysis of rule-based models within a mature, statistically empowered R environment. The infrastructure allows model editing, modification, parameter sampling, simulation, statistical…

Molecular Networks · Quantitative Biology 2014-12-16 Anatoly Sorokin , Oksana Sorokina , J. Douglas Armstrong

Contemporary empirical applications frequently require flexible regression models for complex response types and large tabular or non-tabular, including image or text, data. Classical regression models either break down under the…

Computation · Statistics 2024-05-29 Lucas Kook , Philipp FM Baumann , Oliver Dürr , Beate Sick , David Rügamer

Weighted ensemble (WE) is an enhanced path-sampling method that is conceptually simple, widely applicable, and statistically exact. In a WE simulation, an ensemble of trajectories is periodically pruned or replicated to enhance sampling of…