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Point-scanning microscopy approaches are transforming super-resolution imaging. Despite achieving parallel high-speed imaging using multifocal techniques, efficient multi-color capability with high-quality illumination is currently lacking.…

Optics · Physics 2023-03-14 Ning Xu , Sarah E. Bohndiek , Zexing Li , Cilong Zhang , Qiaofeng Tan

Super-resolution optical microscopy is a rapidly evolving scientific field dedicated to imaging sub-wavelength sized objects, leaving its mark in multiple branches of biology and technology. While several super-resolution optical microscopy…

FRET-based approaches are a unique tool for sensing the immediate surroundings and interactions of (bio)molecules. FRET imaging and FLIM (Fluorescence Lifetime Imaging Microscopy) enable the visualization of the spatial distribution of…

Diffusion models are proficient at generating high-quality images. They are however effective only when operating at the resolution used during training. Inference at a scaled resolution leads to repetitive patterns and structural…

Computer Vision and Pattern Recognition · Computer Science 2024-11-28 Haosen Yang , Adrian Bulat , Isma Hadji , Hai X. Pham , Xiatian Zhu , Georgios Tzimiropoulos , Brais Martinez

Fourier light-field microscopy (FLFM) uses a micro-lens array (MLA) to segment the Fourier Plane of the microscopic objective lens to generate multiple two-dimensional perspective views, thereby reconstructing the three-dimensional(3D)…

Optics · Physics 2022-08-29 Haixin Huang , Haoyuan Qiu , Hanzhe Wu , Yihong Ji , Heng Li , Bin Yu , Danni Chen , Junle Qu

By integrating a phase-only Spatial Light Modulator (SLM) into the illumination arm of a cylindrical-lens-based Selective Plane Illumination Microscope (SPIM), we have created a versatile system able to deliver high quality images by…

Biological Physics · Physics 2018-08-10 Chiara Garbellotto , Jonathan M. Taylor

Light sheet fluorescence microscopy (LSFM) has transformed the way we visualize biological tissues in three dimensions, offering high-resolution imaging while minimizing photo-induced damage to the samples. Recent breakthroughs in…

Optics · Physics 2025-05-27 Alireza Tabatabaei Mashayekh , Jeremy Witzens

We present a detailed investigation of the near-field optical response of core-shell nanoparticles using Fourier-demodulated full-wave simulations, revealing significant modifications to established contrast mechanisms in scattering-type…

We demonstrate a new computational illumination technique that achieves large space-bandwidth-time product, for quantitative phase imaging of unstained live samples in vitro. Microscope lenses can have either large field of view (FOV) or…

Optics · Physics 2015-10-16 Lei Tian , Ziji Liu , Li-Hao Yeh , Michael Chen , Jingshan Zhong , Laura Waller

In recent years several methods to overcome diffraction limit in the far field microscopy have been demonstrated. Still the problem of superresolution is reliably solved only for fluorescent microscopy, giving a resolution of up to 20-30nm.…

Optics · Physics 2013-09-03 Yu. V. Miklyaev , S. A. Asselborn , K. A. Zaytsev , M. Ya. Darscht

Nonlinear distortion experienced by signals during their propagation through optical fibers strongly limits the throughput of optical communication systems. Recently, a strong research focus has been dedicated to nonlinearity mitigation and…

Signal Processing · Electrical Eng. & Systems 2019-03-14 F. Da Ros , S. Civelli , S. Gaiarin , E. P. da Silva , N. De Renzis , M. Secondini , D. Zibar

Nonlinear imaging systems can surpass the limits of linear optics, but to date they have all relied on physical media (e.g. crystals) to work. These materials are all constrained by their physical properties, such as frequency selectivity,…

Optics · Physics 2015-07-31 Jen-Tang Lu , Alexandre S. Goy , Jason W. Fleischer

We present experimental demonstration of tilt-mirror assisted transmission structured illumination microscopy (tSIM) that offers a large field of view super resolution imaging. An assembly of custom-designed tilt-mirrors are employed as the…

The UNet-enhanced Fourier Neural Operator (UFNO) extends the Fourier Neural Operator (FNO) by incorporating a parallel UNet pathway, enabling the retention of both high- and low-frequency components. While UFNO improves predictive accuracy…

Machine Learning · Computer Science 2026-01-05 Alhasan Abdellatif , Hannah P. Menke , Florian Doster , Kamaljit Singh , Ahmed H. Elsheikh

Optical nanoscopy is crucial in life and materials sciences, revealing subtle cellular processes and nanomaterial properties. Scattering-type Scanning Near-field Optical Microscopy (s-SNOM) provides nanoscale resolution, relying on the…

Video-rate super-resolution imaging through biological tissue can visualize and track biomolecule interplays and transportations inside cellular organisms. Structured illumination microscopy allows for wide-field super resolution…

Nonlinear optical (NLO) imaging platforms traditionally rely on refractive microscope objectives, which suffer from chromatic aberrations and temporal dispersion of pulsed excitation light. These issues degrade spatial imaging properties…

Sensing in non-line-of-sight (NLOS) is one of the major challenges for integrated sensing and communication systems. Existing countermeasures for NLOS either use prior knowledge on the environment to characterize all the multiple bounces or…

Signal Processing · Electrical Eng. & Systems 2025-11-20 Davide Tornielli Bellini , Dario Tagliaferri , Pietro Grassi , Davide Scazzoli , Stefano Tebaldini , Umberto Spagnolini

Structured Illumination Microscopy (SIM) overcomes the optical diffraction limit by folding high-frequency components into the baseband of the optical system, where they can be extracted and then repositioned to their original location in…

Optics · Physics 2024-11-18 Doron Shterman , Guy Bartal

Multimode fibers (MMFs) have recently reemerged as attractive avenues for nonlinear effects due to their high-dimensional spatiotemporal nonlinear dynamics and scalability for high power. High-brightness MMF sources with effective control…

Optics · Physics 2023-12-07 Tong Qiu , Honghao Cao , Kunzan Liu , Li-Yu Yu , Manuel Levy , Eva Lendaro , Fan Wang , Sixian You