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We consider the problem of inferring the values of an arbitrary set of variables (e.g., risk of diseases) given other observed variables (e.g., symptoms and diagnosed diseases) and high-dimensional signals (e.g., MRI images or EEG). This is…

Machine Learning · Statistics 2019-02-07 Hao Wang , Chengzhi Mao , Hao He , Mingmin Zhao , Tommi S. Jaakkola , Dina Katabi

Dynamic networks consist of interconnected dynamical systems. The subsystems can be viewed as transformations of input signals into output signals, where signals flow from one system into another through interconnections. The signal flows…

Systems and Control · Electrical Eng. & Systems 2026-04-17 E. M. M. , Kivits , Paul M. J. Van den Hof

Physics-informed neural networks (PINNs) have gained significant prominence as a powerful tool in the field of scientific computing and simulations. Their ability to seamlessly integrate physical principles into deep learning architectures…

Machine Learning · Computer Science 2024-04-05 Zakaria Elabid , Daniel Busby , Abdenour Hadid

We present a physics-inspired method for inferring dynamic rankings in directed temporal networks - networks in which each directed and timestamped edge reflects the outcome and timing of a pairwise interaction. The inferred ranking of each…

We propose the Diffusion-Inversion-Net (DIN) framework for inverse modeling of groundwater flow and solute transport processes. DIN utilizes an offline-trained Denoising Diffusion Probabilistic Model (DDPM) as a powerful prior leaner, which…

Geophysics · Physics 2025-11-24 Xun Zhang , Weijie Yang , Jiangjiang Zhang , Simin Jiang

Synchronization control in networked dynamical systems requires regulating not only whether coherence is achieved, but also when and to what extent it emerges. We propose a physics-informed neural network (PINN) framework for…

Chaotic Dynamics · Physics 2026-01-05 Kaiming Luo

Modeling viscoelastic behavior is crucial in engineering and biomechanics, where materials undergo time-dependent deformations, including stress relaxation, creep buckling and biological tissue development. Traditional numerical methods,…

Computational Engineering, Finance, and Science · Computer Science 2025-12-12 Zhongya Lin , Jinshuai Bai , Shuang Li , Xindong Chen , Bo Li , Xi-Qiao Feng

Current, realistic numerical simulations of the solar atmosphere reproduce observations in a statistical sense; they do not replicate observations such as a movie of solar granulation. Inversions on the other hand reproduce observations by…

Solar and Stellar Astrophysics · Physics 2025-05-09 Christoph U. Keller

This work presents a physics-informed neural network (PINN) based framework to model the strain-rate and temperature dependence of the deformation fields in elastic-viscoplastic solids. To avoid unbalanced back-propagated gradients during…

Materials Science · Physics 2022-11-24 Rajat Arora , Pratik Kakkar , Biswadip Dey , Amit Chakraborty

Identifying the training data samples that most influence a generated image is a critical task in understanding diffusion models (DMs), yet existing influence estimation methods are constrained to small-scale or LoRA-tuned models due to…

Computer Vision and Pattern Recognition · Computer Science 2026-04-10 Huawei Lin , Yingjie Lao , Weijie Zhao

The concept of integrating physics-based and data-driven approaches has become popular for modeling sustainable energy systems. However, the existing literature mainly focuses on the data-driven surrogates generated to replace physics-based…

Machine Learning · Computer Science 2025-01-31 Yicun Huang , Changfu Zou , Yang Li , Torsten Wik

Cells process external and internal signals through chemical interactions. Cells that constitute the immune system (e.g., antigen presenting cell, T-cell, B-cell, mast cell) can have different functions (e.g., adaptive memory, inflammatory…

Molecular Networks · Quantitative Biology 2017-09-21 John A. P. Sekar , James R. Faeder

Numerical methods such as finite element have been flourishing in the past decades for modeling solid mechanics problems via solving governing partial differential equations (PDEs). A salient aspect that distinguishes these numerical…

Numerical Analysis · Mathematics 2020-06-16 Chengping Rao , Hao Sun , Yang Liu

Accurate prediction of protein-ligand binding affinity is crucial for rapid and efficient drug development. Recently, the importance of predicting binding affinity has led to increased attention on research that models the three-dimensional…

Machine Learning · Computer Science 2024-07-17 Seungyeon Choi , Sangmin Seo , Sanghyun Park

The study of cellular signalling pathways and their deregulation in disease states, such as cancer, is a large and extremely complex task. Indeed, these systems involve many parts and processes but are studied piecewise and their…

Artificial Intelligence · Computer Science 2016-08-22 Adrien Basso-Blandin , Walter Fontana , Russ Harmer

The application of deep learning methods to speed up the resolution of challenging power flow problems has recently shown very encouraging results. However, power system dynamics are not snap-shot, steady-state operations. These dynamics…

Machine Learning · Computer Science 2022-06-22 Mostafa Mohammadian , Kyri Baker , Ferdinando Fioretto

Network models are widely used as structural summaries of biochemical systems. Statistical estimation of networks is usually based on linear or discrete models. However, the dynamics of these systems are generally nonlinear, suggesting that…

Applications · Statistics 2014-06-03 C. J. Oates , F. Dondelinger , N. Bayani , J. Korola , J. W. Gray , S. Mukherjee

In the field of pharmacokinetics and pharmacodynamics (PKPD) modeling, which plays a pivotal role in the drug development process, traditional models frequently encounter difficulties in fully encapsulating the complexities of drug…

Quantitative Methods · Quantitative Biology 2024-09-23 Nazanin Ahmadi Daryakenari , Shupeng Wang , George Karniadakis

Physics-Informed Neural Networks (PINNs) have recently emerged as a novel approach to simulate complex physical systems on the basis of both data observations and physical models. In this work, we investigate the use of PINNs for various…

Analysis of PDEs · Mathematics 2024-03-27 Guillaume Coulaud , Maxime Le , Régis Duvigneau

A common issue when analyzing real-world complex systems is that the interactions between the elements often change over time: this makes it difficult to find optimal models that describe this evolution and that can be estimated from data,…

Statistical Finance · Quantitative Finance 2021-08-04 Carlo Campajola , Domenico Di Gangi , Fabrizio Lillo , Daniele Tantari