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This study presents an improved mathematical model for Hepatitis B Virus (HBV) transmission dynamics by investigating autonomous and nonautonomous cases. The novel model incorporates the effects of medical treatment, allowing for a more…

Dynamical Systems · Mathematics 2025-05-15 Abdallah Alsammani

This study develops and analyzes a stochastic differential equation (SDE) model for the dynamics of hepatitis B virus (HBV) infection. While deterministic frameworks have yielded important insights into viral behavior, they cannot…

Dynamical Systems · Mathematics 2025-10-03 Abdallah Alsammani

In this work, a hepatitis B virus infection dynamics model is proposed including the spatial dependence of viruses. The existence of traveling waves for the proposed model is established through the application of the celebrated Gersgorin…

Dynamical Systems · Mathematics 2024-02-06 Rupchand Sutradhar , D C Dalal

Hepatitis B virus (HBV) is considered as etiological agent of the lethal liver disease hepatitis B. Globally, hepatitis B is recognized as one of the prevailing infectious diseases with a significant impact on human health. In spite of…

Quantitative Methods · Quantitative Biology 2024-11-19 Rupchand Sutradhar , Gopinath Sadhu , D C Dalal

Analysis of the cell population generally provides average information about viral infection in a host whereas the intracellular model captures the individual cellular responses. The primary goal of this study is to comprehensively analyze…

Dynamical Systems · Mathematics 2025-05-20 Rupchand Sutradhar , D C Dalal

Hepatitis type B is one of the most common infectious disease worldwide that can pose severe threats to human health up to the point that may contribute to severe liver damage or cancer. Over the past two decades a large number of dynamic…

Quantitative Methods · Quantitative Biology 2020-04-22 SeyedMehdi Abtahi , Mojtaba Sharifi

In this paper, a mathematical analysis of the global dynamics of a partial differential equation viral infection cellular model is carried out. We study the dynamics of a hepatitis C virus (HCV) model, under therapy, that considers both…

Analysis of PDEs · Mathematics 2021-11-08 Alexis Nangue , Bruno Nde Tchiffo

This paper considers a mathematical model based on the transmission dynamics of hepatitis C virus (HCV) infection. In addition to the usual compartments for susceptible, exposed, and infected individuals, this model includes compartments…

Populations and Evolution · Quantitative Biology 2017-12-25 Daniah Tahir , Abid Ali Lashari , Kazeem Oare Okosun

Chronic infection with hepatitis B virus (HBV) can lead to formation of abnormal nodular structures within the liver. To address how changes in liver anatomy affect overall virus-host dynamics, we developed within-host ordinary differential…

Other Quantitative Biology · Quantitative Biology 2025-08-01 Keoni Castellano , Omar Saucedo , Stanca M. Ciupe

Proliferation of uninfected as well as infected hepatocytes and recycling of DNA-containing capsids are two major mechanisms playing significant roles in the clearance of hepatitis B virus (HBV) infection. In this study, the temporal…

Populations and Evolution · Quantitative Biology 2024-01-23 Rupchand Sutradhar , D C Dalal

A new detailed mathematical model for dynamics of immune response to hepatitis B is proposed, which takes into account contributions from innate and adaptive immune responses, as well as cytokines. Stability analysis of different steady…

Populations and Evolution · Quantitative Biology 2018-05-16 F. Fatehi Chenar , Y. N. Kyrychko , K. B. Blyuss

In this paper, a mathematical analysis of the global dynamics of a viral infection model in vivo is carried out. We study the dynamics of a hepatitis C virus (HCV) model, under therapy, that considers both extracellular and intracellular…

Populations and Evolution · Quantitative Biology 2020-11-13 Alexis Nangue , Alan D. Rendall , Brice Kammegne Tcheugam , Patrick Steve Kamdem Simo

We investigate the dynamics of the hepatitis B virus by integrating variable-order calculus and discrete analysis. Specifically, we utilize the Caputo variable-order difference operator in this study. To establish the existence and…

Populations and Evolution · Quantitative Biology 2024-05-27 Meriem Boukhobza , Amar Debbouche , Lingeshwaran Shangerganesh , Delfim F. M. Torres

We consider a mathematical model comprising of four coupled ordinary differential equations (ODEs) for studying the hepatitis C (HCV) viral dynamics. The model embodies the efficacies of a combination therapy of interferon and ribavirin. A…

Quantitative Methods · Quantitative Biology 2015-05-28 Gaurav Pachpute , Siddhartha P. Chakrabarty

A mathematical modeling of Hepatitis C Virus (HCV) dynamics has been presented in this paper. The proposed model, which involves four coupled ordinary differential equations, describes the interaction of target cells (hepatocytes), infected…

Cell Behavior · Quantitative Biology 2011-05-19 Sandip Banerjee , Ram Keval , S. Gakkhar

This research gives a thorough examination of an HIV infection model that includes quiescent cells and immune response dynamics in the host. The model, represented by a system of ordinary differential equations, captures the complex…

Populations and Evolution · Quantitative Biology 2025-03-04 Ibrahim Nali , Attila Dénes , Abdessamad Tridane , Xueyong Zhou

The aims of this work is to analyse of the global stability of the extended model of hepatitis C virus(HCV) infection with cellular proliferation, spontaneous cure and hepatocyte homeostasis. We first give general information about…

Dynamical Systems · Mathematics 2019-05-08 Alexis Nangue , Cyprien Fokoue , Raoue Poumeni

Tuberculosis (TB) continues to pose a major public health challenge, particularly in high-burden regions such as Ethiopia, necessitating a more profound understanding of its transmission dynamics. In this study, we developed an SVEITRS…

Populations and Evolution · Quantitative Biology 2025-06-26 Moksina Seyid , Abdu Mohammed Seid , Yassin Tesfaw Abebe

Hepatitis B virus is a global health threat, and its elimination by 2030 has been prioritised by the World Health Organisation. Here we present an age-structured model for the immune response to an HBV infection, which takes into account…

Quantitative Methods · Quantitative Biology 2021-08-05 Farzad Fatehi , Richard J. Bingham , Eric C. Dykeman , Peter G. Stockley , Reidun Twarock

In this manuscript we consider an age structured epidemic system modelling the dynamics of transmission of immunizing disease like Hepatitis B virus. Our model takes into account age as well as two classes of infected individuals (chronic…

Analysis of PDEs · Mathematics 2016-05-17 Yannick Tchaptchie Kouakep
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