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Most prediction models that are used in medical research fail to accurately predict health outcomes due to methodological limitations. Using routinely collected patient data, we explore the use of a Cox proportional hazard (PH) model within…

Methodology · Statistics 2019-07-19 John Mbotwa , Marc de Kamps , Paul D. Baxter , Mark S. Gilthorpe

In this work a method to regularize Cox frailty models is proposed that accommodates time-varying covariates and time-varying coefficients and is based on the full instead of the partial likelihood. A particular advantage in this framework…

Methodology · Statistics 2020-04-01 Maike Hohberg , Andreas Groll

We consider the problem of variable selection in high-dimensional sparse additive models. We focus on the case that the components belong to nonparametric classes of functions. The proposed method is motivated by geometric considerations in…

Statistics Theory · Mathematics 2015-02-03 Martin Wahl

Survival analysis is widely deployed in a diverse set of fields, including healthcare, business, ecology, etc. The Cox Proportional Hazard (CoxPH) model is a semi-parametric model often encountered in the literature. Despite its popularity,…

Machine Learning · Computer Science 2025-05-29 Chengzhi Shi , Stratis Ioannidis

R. A. Fisher introduced the fiducial distribution as a potential replacement for the Bayesian posterior distribution in the 1930s. During the past century, fiducial approaches have been explored in various parametric and nonparametric…

Methodology · Statistics 2026-05-12 Yifan Cui , Jan Hannig , Paul Edlefsen

We propose a novel frailty model with change points applying random effects to a Cox proportional hazard model to adjust the heterogeneity between clusters. Because the frailty model includes random effects, the parameters are estimated…

Methodology · Statistics 2023-01-12 Masahiro Kojima , Shunichiro Orihara

This work addresses the problem of high-dimensional classification by exploring the generalized Bayesian logistic regression method under a sparsity-inducing prior distribution. The method involves utilizing a fractional power of the…

Statistics Theory · Mathematics 2024-03-20 The Tien Mai

This paper considers the problem of semi-parametric proportional hazards model fitting for interval, left and right censored survival times. We adopt a more versatile penalized likelihood method to estimate the baseline hazard and the…

Methodology · Statistics 2019-04-16 Jun Ma , Dominique-Laurent Couturier , Stephane Heritier , Ian Marschner

Cox proportional hazards model with measurement errors is considered. In Kukush and Chernova (2017), we elaborated a simultaneous estimator of the baseline hazard rate $\lambda(\cdot)$ and the regression parameter $\beta$, with the…

Probability · Mathematics 2018-04-06 Oksana Chernova , Alexander Kukush

Survival models are a popular tool for the analysis of time to event data with applications in medicine, engineering, economics, and many more. Advances like the Cox proportional hazard model have enabled researchers to better describe…

Machine Learning · Statistics 2021-02-16 Stefan Groha , Sebastian M Schmon , Alexander Gusev

In this paper we address the challenges posed by non-proportional hazards and informative censoring, offering a path toward more meaningful causal inference conclusions. We start from the marginal structural Cox model, which has been widely…

Methodology · Statistics 2023-11-15 Jiyu Luo , Denise Rava , Jelena Bradic , Ronghui Xu

A regression model is proposed for the analysis of an ordinal response variable depending on a set of multiple covariates containing ordinal and potentially other variables. The proportional odds model (McCullagh (1980)) is used for the…

Methodology · Statistics 2018-04-25 Javier Espinosa , Christian Hennig

Identifying and characterizing relationships between treatments, exposures, or other covariates and time-to-event outcomes has great significance in a wide range of biomedical settings. In research areas such as multi-center clinical…

Methodology · Statistics 2025-04-02 Hillary M. Heiling , Naim U. Rashid , Quefeng Li , Xianlu L. Peng , Jen Jen Yeh

Meinshausen and Buhlmann [Ann. Statist. 34 (2006) 1436--1462] showed that, for neighborhood selection in Gaussian graphical models, under a neighborhood stability condition, the LASSO is consistent, even when the number of variables is of…

Statistics Theory · Mathematics 2008-08-08 Cun-Hui Zhang , Jian Huang

This paper proposes a multi-stage projection-based Lasso procedure for the semiparametric sample selection model in high-dimensional settings under a weak nonparametric restriction on the selection correction. In particular, the number of…

Statistics Theory · Mathematics 2014-11-13 Ying Zhu

The cause of failure in cohort studies that involve competing risks is frequently incompletely observed. To address this, several methods have been proposed for the semiparametric proportional cause-specific hazards model under a missing at…

Methodology · Statistics 2020-02-24 Giorgos Bakoyannis , Ying Zhang , Constantin T. Yiannoutsos

In multivariate regression, when covariates are numerous, it is often reasonable to assume that only a small number of them has predictive information. In some medical applications for instance, it is believed that only a few genes out of…

Methodology · Statistics 2022-07-12 Sylvain Sardy , Xiaoyu Ma

We consider learning high-dimensional multi-response linear models with structured parameters. By exploiting the noise correlations among responses, we propose an alternating estimation (AltEst) procedure to estimate the model parameters…

Machine Learning · Statistics 2016-06-30 Sheng Chen , Arindam Banerjee

Hazard ratios are often used to evaluate time to event outcomes, but they may be hard to interpret. A particular issue arise because hazards are typically estimated conditional on survival, i.e.\ on left truncated samples. Then, hazard…

Methodology · Statistics 2018-03-23 Mats Julius Stensrud

In many applications one may acquire a composition of several signals that may be corrupted by noise, and it is a challenging problem to reliably separate the components from one another without sacrificing significant details. Adding to…

Numerical Analysis · Mathematics 2015-01-21 Ashley Prater , Lixin Shen
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