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Quantum computing promises to speed up some of the most challenging problems in science and engineering. Quantum algorithms have been proposed showing theoretical advantages in applications ranging from chemistry to logistics optimization.…

Quantum Physics · Physics 2021-11-12 Niklas Heim , Atiyo Ghosh , Oleksandr Kyriienko , Vincent E. Elfving

The vast complexity is a daunting property of generic quantum states that poses a significant challenge for theoretical treatment, especially in non-equilibrium setups. Therefore, it is vital to recognize states which are locally less…

Quantum Physics · Physics 2022-07-28 Markus Schmitt , Zala Lenarčič

Physics-constrained data-driven computing is an emerging computational paradigm that allows simulation of complex materials directly based on material database and bypass the classical constitutive model construction. However, it remains…

Numerical Analysis · Mathematics 2022-09-12 Xiaolong He , Qizhi He , Jiun-Shyan Chen

The choice of constellations largely affects the performance of communication systems. When designing constellations, both the locations and probability of occurrence of the points can be optimized. These approaches are referred to as…

Information Theory · Computer Science 2019-08-30 Maximilian Stark , Fayçal Ait Aoudia , Jakob Hoydis

Reinforcement learning (RL) is a promising method for quantum circuit optimisation. However, the state space that has to be explored by an RL agent is extremely large when considering all the possibilities in which a quantum circuit can be…

Quantum Physics · Physics 2023-03-07 Ioana Moflic , Vikas Garg , Alexandru Paler

The ability to perform ab initio molecular dynamics simulations using potential energies calculated on quantum computers would allow virtually exact dynamics for chemical and biochemical systems, with substantial impacts on the fields of…

The problem of identifying geometric structure in data is a cornerstone of (unsupervised) learning. As a result, Geometric Representation Learning has been widely applied across scientific and engineering domains. In this work, we…

Machine Learning · Computer Science 2025-06-03 Imran Nasim , Melanie Weber

An algorithm for generating optimal nonuniform grids for solving the two-body Schr\"odinger equation is developed and implemented. The shape of the grid is optimized to accurately reproduce the low-energy part of the spectrum of the…

Computational Physics · Physics 2015-05-20 Vladimir Roudnev , Michael Cavagnero

In the last years, deep learning has shown to be a game-changing technology in artificial intelligence thanks to the numerous successes it reached in diverse application fields. Among others, the use of deep learning for the recommendation…

Information Retrieval · Computer Science 2018-07-16 Vito Bellini , Angelo Schiavone , Tommaso Di Noia , Azzurra Ragone , Eugenio Di Sciascio

Graph neural networks (GNNs) have been used extensively for addressing problems in drug design and discovery. Both ligand and target molecules are represented as graphs with node and edge features encoding information about atomic elements…

Machine Learning · Computer Science 2021-10-14 Dhananjay Bhaskar , Jackson D. Grady , Michael A. Perlmutter , Smita Krishnaswamy

Optimizing the topology of networks is an important challenge across engineering disciplines. In energy systems, network reconfiguration can substantially reduce losses and costs and thus support the energy transition. Unfortunately, many…

We present a variational autoencoder framework for learning and generating configurations of structured polymer globules from distance matrices. We used coarse-grained molecular dynamics to sample polyethylene structures, which we used as…

Optimally-shaped electromagnetic fields have the capacity to coherently control the dynamics of quantum systems and thus offer a promising means for controlling molecular transformations relevant to chemical, biological, and materials…

Quantum Physics · Physics 2021-06-08 Alicia B. Magann , Matthew D. Grace , Herschel A. Rabitz , Mohan Sarovar

Geometry optimization is an important part of both computational materials and surface science because it is the path to finding ground state atomic structures and reaction pathways. These properties are used in the estimation of…

Materials Science · Physics 2021-07-07 Yilin Yang , Omar A. Jimenez-Negron , John R. Kitchin

Active quantum error correction is a central ingredient to achieve robust quantum processors. In this paper we investigate the potential of quantum machine learning for quantum error correction in a quantum memory. Specifically, we…

Quantum Physics · Physics 2023-03-15 David F. Locher , Lorenzo Cardarelli , Markus Müller

The one-body reduced density matrix (1-RDM) of a many-body system at zero temperature gives direct access to many observables, such as the charge density, kinetic energy and occupation numbers. It would be desirable to express it as a…

Computational Physics · Physics 2021-01-27 Jack Wetherell , Andrea Costamagna , Matteo Gatti , Lucia Reining

The use of multigrid and related preconditioners with the finite element method is often limited by the difficulty of applying the algorithm effectively to a problem, especially when the domain has a complex shape or adaptive refinement. We…

Numerical Analysis · Computer Science 2015-03-19 Peter R. Brune , Matthew G. Knepley , L. Ridgway Scott

In structure-based virtual screening, it is often necessary to evaluate the binding free energy of protein-ligand complexes by considering not only molecular conformations but also how these structures shift and rotate in space. The number…

Quantum Physics · Physics 2025-07-25 Pei-Kun Yang

Quantum computing technologies are in the process of moving from academic research to real industrial applications, with the first hints of quantum advantage demonstrated in recent months. In these early practical uses of quantum computers…

We introduce the Kernel-Elastic Autoencoder (KAE), a self-supervised generative model based on the transformer architecture with enhanced performance for molecular design. KAE is formulated based on two novel loss functions: modified…

Machine Learning · Computer Science 2024-03-26 Haote Li , Yu Shee , Brandon Allen , Federica Maschietto , Victor Batista