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Electronic health record (EHR) foundation models have been an area ripe for exploration with their improved performance in various medical tasks. Despite the rapid advances, there exists a fundamental limitation: Processing unseen medical…

Artificial Intelligence · Computer Science 2025-08-15 Junmo Kim , Namkyeong Lee , Jiwon Kim , Kwangsoo Kim

Embeddings of medical concepts such as medication, procedure and diagnosis codes in Electronic Medical Records (EMRs) are central to healthcare analytics. Previous work on medical concept embedding takes medical concepts and EMRs as words…

Computation and Language · Computer Science 2018-06-11 Xiangrui Cai , Jinyang Gao , Kee Yuan Ngiam , Beng Chin Ooi , Ying Zhang , Xiaojie Yuan

With the recent availability of Electronic Health Records (EHR) and great opportunities they offer for advancing medical informatics, there has been growing interest in mining EHR for improving quality of care. Disease diagnosis due to its…

Artificial Intelligence · Computer Science 2018-04-24 Anahita Hosseini , Ting Chen , Wenjun Wu , Yizhou Sun , Majid Sarrafzadeh

Identifying relationships between concepts is a key aspect of scientific knowledge synthesis. Finding these links often requires a researcher to laboriously search through scien- tific papers and databases, as the size of these resources…

Computation and Language · Computer Science 2016-02-12 Stephanie L. Hyland , Theofanis Karaletsos , Gunnar Rätsch

Missing values in electronic health record (EHR) data pose a significant challenge for epidemiologic research. Traditional methods for handling missing data, like mean imputation, may introduce bias. Multiple imputation (MI) offers a…

The extraction of critical patient information from Electronic Health Records (EHRs) poses significant challenges due to the complexity and unstructured nature of the data. Traditional machine learning approaches often fail to capture…

Computation and Language · Computer Science 2025-09-03 Zhimeng Luo , Abhibha Gupta , Adam Frisch , Daqing He

Increasingly large electronic health records (EHRs) provide an opportunity to algorithmically learn medical knowledge. In one prominent example, a causal health knowledge graph could learn relationships between diseases and symptoms and…

Applications · Statistics 2019-10-04 Irene Y. Chen , Monica Agrawal , Steven Horng , David Sontag

Deep learning models exhibit state-of-the-art performance for many predictive healthcare tasks using electronic health records (EHR) data, but these models typically require training data volume that exceeds the capacity of most healthcare…

Machine Learning · Computer Science 2018-10-24 Edward Choi , Cao Xiao , Walter F. Stewart , Jimeng Sun

Machine Reading Comprehension (MRC) aims to extract answers to questions given a passage. It has been widely studied recently, especially in open domains. However, few efforts have been made on closed-domain MRC, mainly due to the lack of…

Computation and Language · Computer Science 2021-08-23 Taolin Zhang , Chengyu Wang , Minghui Qiu , Bite Yang , Xiaofeng He , Jun Huang

Medical deep learning models depend heavily on domain-specific knowledge to perform well on knowledge-intensive clinical tasks. Prior work has primarily leveraged unimodal knowledge graphs, such as the Unified Medical Language System…

Artificial Intelligence · Computer Science 2025-05-26 Xiaochen Wang , Yuan Zhong , Lingwei Zhang , Lisong Dai , Ting Wang , Fenglong Ma

Effectively representing medical concepts and patients is important for healthcare analytical applications. Representing medical concepts for healthcare analytical tasks requires incorporating medical domain knowledge and prior information…

Machine Learning · Computer Science 2023-05-02 Shaodong Wang , Qing Li , Wenli Zhang

Cancer remains one of the most challenging diseases to treat in the medical field. Machine learning has enabled in-depth analysis of rich multi-omics profiles and medical imaging for cancer diagnosis and prognosis. Despite these…

Machine Learning · Computer Science 2024-01-15 Lingchao Mao , Hairong Wang , Leland S. Hu , Nhan L Tran , Peter D Canoll , Kristin R Swanson , Jing Li

This study addresses a critical gap in the healthcare system by developing a clinically meaningful, practical, and explainable disease surveillance system for multiple chronic diseases, utilizing routine EHR data from multiple U.S.…

Machine Learning · Computer Science 2025-01-28 Shaheer Ahmad Khan , Muhammad Usamah Shahid , Ahmad Abdullah , Ibrahim Hashmat , Muddassar Farooq

Background: Electronic Health Records (EHRs) contain rich information of patients' health history, which usually include both structured and unstructured data. There have been many studies focusing on distilling valuable information from…

Machine Learning · Computer Science 2021-11-10 Ziyi Liu , Jiaqi Zhang , Yongshuai Hou , Xinran Zhang , Ge Li , Yang Xiang

Electronic health records (EHR's) are only a first step in capturing and utilizing health-related data - the problem is turning that data into useful information. Models produced via data mining and predictive analysis profile inherited…

Databases · Computer Science 2011-12-08 Casey Bennett , Thomas Doub

Knowledge graph completion aims to predict the new links in given entities among the knowledge graph (KG). Most mainstream embedding methods focus on fact triplets contained in the given KG, however, ignoring the rich background information…

Artificial Intelligence · Computer Science 2020-10-13 Zhaochong An , Bozhou Chen , Houde Quan , Qihui Lin , Hongzhi Wang

Both electronic health records and personal health records are typically organized by data type, with medical problems, medications, procedures, and laboratory results chronologically sorted in separate areas of the chart. As a result, it…

Machine Learning · Computer Science 2020-08-10 James Mullenbach , Jordan Swartz , T. Greg McKelvey , Hui Dai , David Sontag

Latent space models are widely used for analyzing high-dimensional discrete data matrices, such as patient-feature matrices in electronic health records (EHRs), by capturing complex dependence structures through low-dimensional embeddings.…

Machine Learning · Computer Science 2026-02-19 Weijing Tang , Ming Yuan , Zongqi Xia , Tianxi Cai

Electronic medical records (EMRs), particularly in neurology, are inherently heterogeneous, sparse, and noisy, which poses significant challenges for large language models (LLMs) in clinical diagnosis. In such settings, single-agent systems…

Artificial Intelligence · Computer Science 2026-04-30 Shaowei Shen , Xiaohong Yang , Jie Yang , Lianfen Huang , Yongcai Zhang , Yang Zou , Seyyedali Hosseinalipour

Machine learning holds great promise for advancing the field of medicine, with electronic health records (EHRs) serving as a primary data source. However, EHRs are often sparse and contain missing data due to various challenges and…

Machine Learning · Computer Science 2026-02-25 Jun Han , Josue Nassar , Sanjit Singh Batra , Aldo Cordova-Palomera , Vijay Nori , Robert E. Tillman