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A large-scale knowledge graph enhances reproducibility in biomedical data discovery by providing a standardized, integrated framework that ensures consistent interpretation across diverse datasets. It improves generalizability by connecting…

Methodology · Statistics 2024-10-11 Suqi Liu , Tianxi Cai , Xiaoou Li

Electronic Health Records (EHR) are high-dimensional data with implicit connections among thousands of medical concepts. These connections, for instance, the co-occurrence of diseases and lab-disease correlations can be informative when…

Machine Learning · Computer Science 2021-03-29 Weicheng Zhu , Narges Razavian

Sequence labeling for extraction of medical events and their attributes from unstructured text in Electronic Health Record (EHR) notes is a key step towards semantic understanding of EHRs. It has important applications in health informatics…

Computation and Language · Computer Science 2016-07-13 Abhyuday Jagannatha , Hong Yu

Medical Decision-Making (MDM) is a complex process requiring substantial domain-specific expertise to effectively synthesize heterogeneous and complicated clinical information. While recent advancements in Large Language Models (LLMs) show…

Artificial Intelligence · Computer Science 2025-08-20 Liuxin Bao , Zhihao Peng , Xiaofei Zhou , Runmin Cong , Jiyong Zhang , Yixuan Yuan

Electronic health records (EHRs) are designed to synthesize diverse data types, including unstructured clinical notes, structured lab tests, and time-series visit data. Physicians draw on these multimodal and temporal sources of EHR data to…

Objectives: The fee-for-service approach to healthcare leads to the management of a patient's conditions in an independent manner, inducing various negative consequences. It is recognized that a bundled care approach to healthcare-one that…

Computers and Society · Computer Science 2017-06-05 You Chen , Abel N. Kho , David Liebovitz , Catherine Ivory , Sarah Osmundson , Jiang Bian , Bradley A. Malin

Due to the increasing adoption of electronic health records (EHR), large scale EHRs have become another rich data source for translational clinical research. Despite its potential, deriving generalizable knowledge from EHR data remains…

Machine Learning · Statistics 2023-06-01 Junwei Lu , Jin Yin , Tianxi Cai

Electronic health records (EHRs) contain patients' heterogeneous data that are collected from medical providers involved in the patient's care, including medical notes, clinical events, laboratory test results, symptoms, and diagnoses. In…

Artificial Intelligence · Computer Science 2024-11-12 Shuai Niu , Yunya Song , Qing Yin , Yike Guo , Xian Yang

The integration of multimodal Electronic Health Records (EHR) data has significantly advanced clinical predictive capabilities. Existing models, which utilize clinical notes and multivariate time-series EHR data, often fall short of…

Computation and Language · Computer Science 2025-02-27 Yinghao Zhu , Changyu Ren , Zixiang Wang , Xiaochen Zheng , Shiyun Xie , Junlan Feng , Xi Zhu , Zhoujun Li , Liantao Ma , Chengwei Pan

The automation of the medical evidence acquisition and diagnosis process has recently attracted increasing attention in order to reduce the workload of doctors and democratize access to medical care. However, most works proposed in the…

Computation and Language · Computer Science 2022-10-14 Arsene Fansi Tchango , Rishab Goel , Julien Martel , Zhi Wen , Gaetan Marceau Caron , Joumana Ghosn

The automatic construction of knowledge graphs (KGs) is an important research area in medicine, with far-reaching applications spanning drug discovery and clinical trial design. These applications hinge on the accurate identification of…

Computation and Language · Computer Science 2025-01-30 Vahan Arsenyan , Spartak Bughdaryan , Fadi Shaya , Kent Small , Davit Shahnazaryan

Evidence-based medicine (EBM) plays a crucial role in the application of large language models (LLMs) in healthcare, as it provides reliable support for medical decision-making processes. Although it benefits from current…

Computation and Language · Computer Science 2025-03-24 Chengfeng Dou , Ying Zhang , Zhi Jin , Wenpin Jiao , Haiyan Zhao , Yongqiang Zhao , Zhengwei Tao

Electronic Health Records (EHR)-based disease prediction models have demonstrated significant clinical value in promoting precision medicine and enabling early intervention. However, existing large language models face two major challenges:…

Computation and Language · Computer Science 2025-06-19 Junke Wang , Hongshun Ling , Li Zhang , Longqian Zhang , Fang Wang , Yuan Gao , Zhi Li

The use of Electronic Health Records (EHRs) has increased dramatically in the past 15 years, as, it is considered an important source of managing data od patients. The EHRs are primary sources of disease diagnosis and demographic data of…

Machine Learning · Computer Science 2024-04-02 Bushra F. Alsaqer , Alaa F. Alsaqer , Amna Asif

The continuously increasing cost of the US healthcare system has received significant attention. Central to the ideas aimed at curbing this trend is the use of technology, in the form of the mandate to implement electronic health records…

Information Retrieval · Computer Science 2017-03-24 Pranjul Yadav , Michael Steinbach , Vipin Kumar , Gyorgy Simon

Objective: To improve prediction of Chronic Kidney Disease (CKD) progression to End Stage Renal Disease (ESRD) using machine learning (ML) and deep learning (DL) models applied to an integrated clinical and claims dataset of varying…

Quantitative Methods · Quantitative Biology 2025-05-06 Yubo Li , Rema Padman

Multimodal Large Language Models (MLLMs) have shown transformative potential in medical applications, yet their performance is hindered by conventional data curation strategies that rely on coarse-grained partitioning by modality or…

Computation and Language · Computer Science 2026-04-29 Jianghang Lin , Haihua Yang , Deli Yu , Kai Wu , Kai Ye , Jinghao Lin , Zihan Wang , Yuhang Wu , Liujuan Cao

Electronic medical records (EMRs) contain the majority of patients' healthcare details. It is an abundant resource for developing an automatic healthcare system. Most of the natural language processing (NLP) studies on EMR processing, such…

Computation and Language · Computer Science 2024-10-01 Hongyi Yuan , Sheng Yu

Question answering is a natural language understanding task that involves reasoning over both explicit context, and unstated relevant domain knowledge. Despite the high cost of training, large language models (LLMs) -- the backbone of most…

Computation and Language · Computer Science 2025-04-24 Laura Cabello , Carmen Martin-Turrero , Uchenna Akujuobi , Anders Søgaard , Carlos Bobed

Recent studies show that deep learning models achieve good performance on medical imaging tasks such as diagnosis prediction. Among the models, multimodality has been an emerging trend, integrating different forms of data such as chest…

Machine Learning · Computer Science 2022-02-10 Haodi Zhang , Chenyu Xu , Peirou Liang , Ke Duan , Hao Ren , Weibin Cheng , Kaishun Wu