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Dynamic Causal Modeling (DCM) is a Bayesian framework for inferring on hidden (latent) neuronal states, based on measurements of brain activity. Since its introduction in 2003 for functional magnetic resonance imaging data, DCM has been…

Quantitative Methods · Quantitative Biology 2021-04-08 Inês Pereira , Stefan Frässle , Jakob Heinzle , Dario Schöbi , Cao Tri Do , Moritz Gruber , Klaas E. Stephan

Effective connectivity analysis in functional magnetic resonance imaging (fMRI) studies directional interactions among brain regions and experimental stimuli. Dynamic causal modeling (DCM) is a widely used method to estimate effective…

Methodology · Statistics 2026-05-15 Kaitlyn R. Fales , Hyebin Song , Nicole A. Lazar

Experimental manipulations perturb the neuronal activity. This phenomenon is manifested in the fMRI response. Dynamic causal model and its variants can model these neuronal responses along with the BOLD responses [1, 2, 3, 4, 5] .…

Neurons and Cognition · Quantitative Biology 2021-01-15 Sayan Nag

This paper introduces a novel approach for modelling time-varying connectivity in neuroimaging data, focusing on the slow fluctuations in synaptic efficacy that mediate neuronal dynamics. Building on the framework of Dynamic Causal…

Neurons and Cognition · Quantitative Biology 2024-12-05 Johan Medrano , Karl J. Friston , Peter Zeidman

We present a didactic introduction to spectral Dynamic Causal Modelling (DCM), a Bayesian state-space modelling approach used to infer effective connectivity from non-invasive neuroimaging data. Spectral DCM is currently the most widely…

Neurons and Cognition · Quantitative Biology 2023-09-07 Leonardo Novelli , Karl Friston , Adeel Razi

Robust characterization of dynamic causal interactions in multivariate biomedical signals is essential for advancing computational and algorithmic methods in biomedical imaging. Conventional approaches, such as Dynamic Bayesian Networks…

Signal Processing · Electrical Eng. & Systems 2026-02-17 Farwa Abbas , Wei Dai , Zoran Cvetkovic , Verity McClelland

Given data obtained under two sampling conditions, it is often of interest to identify variables that behave differently in one condition than in the other. We introduce a method for differential analysis of second-order behavior called…

Methodology · Statistics 2016-02-26 Kelly Bodwin , Kai Zhang , Andrew Nobel

Causal investigations in observational studies pose a great challenge in research where randomized trials or intervention-based studies are not feasible. We develop an information geometric causal discovery and inference framework of…

Methodology · Statistics 2023-11-08 Soumik Purkayastha , Peter X. K. Song

Dynamical systems are widely used in science and engineering to model systems consisting of several interacting components. Often, they can be given a causal interpretation in the sense that they not only model the evolution of the states…

Artificial Intelligence · Computer Science 2022-03-29 Stephan Bongers , Tineke Blom , Joris M. Mooij

Discrete choice models are essential for modelling various decision-making processes in human behaviour. However, the specification of these models has depended heavily on domain knowledge from experts, and the fully automated but…

Machine Learning · Computer Science 2025-07-16 Fumiyasu Makinoshima , Tatsuya Mitomi , Fumiya Makihara , Eigo Segawa

We study a specific type of SCM, called a Dynamic Structural Causal Model (DSCM), whose endogenous variables represent functions of time, which is possibly cyclic and allows for latent confounding. As a motivating use-case, we show that…

Statistics Theory · Mathematics 2024-07-23 Philip Boeken , Joris M. Mooij

Discrete choice models (DCMs) have been widely utilized in various scientific fields, especially economics, for many years. These models consider a stochastic environment influencing each decision maker's choices. Extensive research has…

General Economics · Economics 2026-01-13 Amirreza Talebi

A notion of directed information between two continuous-time processes is proposed. A key component in the definition is taking an infimum over all possible partitions of the time interval, which plays a role no less significant than the…

Information Theory · Computer Science 2012-11-01 Tsachy Weissman , Young-Han Kim , Haim H. Permuter

Dynamic Causal Modelling (DCM) is the predominant method for inferring effective connectivity from neuroimaging data. In the 15 years since its introduction, the neural models and statistical routines in DCM have developed in parallel,…

Quantitative Methods · Quantitative Biology 2019-07-15 Peter Zeidman , Amirhossein Jafarian , Nadège Corbin , Mohamed L. Seghier , Adeel Razi , Cathy J. Price , Karl J. Friston

We consider the problem of answering observational, interventional, and counterfactual queries in a causally sufficient setting where only observational data and the causal graph are available. Utilizing the recent developments in diffusion…

Machine Learning · Statistics 2024-10-11 Patrick Chao , Patrick Blöbaum , Sapan Patel , Shiva Prasad Kasiviswanathan

Dynamic mode decomposition (DMD) is a versatile approach that enables the construction of low-order models from data. Controller design tasks based on such models require estimates and guarantees on predictive accuracy. In this work, we…

Systems and Control · Electrical Eng. & Systems 2020-03-24 Qiugang Lu , Sungho Shin , Victor M. Zavala

Dynamic effective connectivity networks (dECNs) reveal the changing directed brain activity and the dynamic causal influences among brain regions, which facilitate the identification of individual differences and enhance the understanding…

Machine Learning · Computer Science 2025-02-03 Faming Xu , Yiding Wang , Chen Qiao , Gang Qu , Vince D. Calhoun , Julia M. Stephen , Tony W. Wilson , Yu-Ping Wang

Understanding the complex mechanisms of the brain can be unraveled by extracting the Dynamic Effective Connectome (DEC). Recently, score-based Directed Acyclic Graph (DAG) discovery methods have shown significant improvements in extracting…

Neurons and Cognition · Quantitative Biology 2024-03-12 Abdolmahdi Bagheri , Mohammad Pasande , Kevin Bello , Babak Nadjar Araabi , Alireza Akhondi-Asl

Structural Causal Models are widely used in causal modelling, but how they relate to other modelling tools is poorly understood. In this paper we provide a novel perspective on the relationship between Ordinary Differential Equations and…

Artificial Intelligence · Computer Science 2022-08-31 Paul K. Rubenstein , Stephan Bongers , Bernhard Schoelkopf , Joris M. Mooij

The relationship between brain structure and function has been probed using a variety of approaches, but how the underlying structural connectivity of the human brain drives behavior is far from understood. To investigate the effect of…

Neurons and Cognition · Quantitative Biology 2018-11-15 Kanika Bansal , John D. Medaglia , Danielle S. Bassett , Jean M. Vettel , Sarah F. Muldoon
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