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The identification of the interfacial molecules in fluid-fluid equilibrium is a long-standing problem in the area of simulation. We here propose a new point of view, making use of concepts taken from the field of computational geometry,…

Soft Condensed Matter · Physics 2009-04-30 Florencio Balboa Usabiaga , Daniel Duque

The dipole moment is a physical quantity indicating the polarity of a molecule and is determined by reflecting the electrical properties of constituent atoms and the geometric properties of the molecule. Most embeddings used to represent…

Machine Learning · Computer Science 2022-06-28 Yang Jeong Park

Interactions and relations between objects may be pairwise or higher-order in nature, and so network-valued data are ubiquitous in the real world. The "space of networks", however, has a complex structure that cannot be adequately described…

Metric Geometry · Mathematics 2024-12-09 Stephen Y Zhang , Fangfei Lan , Youjia Zhou , Agnese Barbensi , Michael P H Stumpf , Bei Wang , Tom Needham

Predicting the local dynamics of supercooled liquids based purely on local structure is a key challenge in our quest for understanding glassy materials. Recent years have seen an explosion of methods for making such a prediction, often via…

Soft Condensed Matter · Physics 2021-08-25 Emanuele Boattini , Frank Smallenburg , Laura Filion

Advances in machine learning have led to graph neural network-based methods for drug discovery, yielding promising results in molecular design, chemical synthesis planning, and molecular property prediction. However, current graph neural…

Quantitative Methods · Quantitative Biology 2021-07-13 Jiahua Rao , Shuangjia Zheng , Yuedong Yang

The concepts of geometric-arithmetic and harmonic indices were introduced in the area of chemical graph theory recently. They have proven to correlate well with physical and chemical properties of some molecules. The aim of this paper is to…

Combinatorics · Mathematics 2020-04-08 Walter Carballosa , Ana Granados , Domingo Pestana , Ana Portilla , Jose María Sigarreta

Prediction of solubility has been a complex and challenging physiochemical problem that has tremendous implications in the chemical and pharmaceutical industry. Recent advancements in machine learning methods have provided great scope for…

Disordered Systems and Neural Networks · Physics 2024-02-20 Vansh Ramani , Tarak Karmakar

Predicting the properties of a molecule from its structure is a challenging task. Recently, deep learning methods have improved the state of the art for this task because of their ability to learn useful features from the given data. By…

Machine Learning · Computer Science 2020-08-28 Shengli Jiang , Prasanna Balaprakash

The edge-Wiener index of a connected graph $G$ is defined as the Wiener index of the line graph of $G$. In this paper it is shown that the edge-Wiener index of an edge-weighted graph can be computed in terms of the Wiener index, the…

Combinatorics · Mathematics 2020-10-21 Niko Tratnik

We introduce a novel equivariant graph neural network (GNN) architecture designed to predict the tensorial response properties of molecules. Unlike traditional frameworks that focus on regressing scalar quantities and derive tensorial…

Machine Learning · Computer Science 2025-11-11 Jean Philip Filling , Felix Post , Michael Wand , Denis Andrienko

Background: Virtual Screening (VS) has become an essential tool in drug discovery, enabling the rapid and cost-effective identification of potential bioactive molecules. Among recent advancements, Graph Neural Networks (GNNs) have gained…

Quantitative Methods · Quantitative Biology 2025-10-27 Salvatore Contino , Paolo Sortino , Maria Rita Gulotta , Ugo Perricone , Roberto Pirrone

Signaling proteins are an important topic in drug development due to the increased importance of finding fast, accurate and cheap methods to evaluate new molecular targets involved in specific diseases. The complexity of the protein…

Quantitative Methods · Quantitative Biology 2019-04-11 Carlos Fernandez-Lozano , Ruben F. Cuinas , Jose A. Seoane , Enrique Fernandez-Blanco , Julian Dorado , Cristian R. Munteanu

We give conditions for the existence of the Minkowski content of limit sets stemming from infinite conformal graph directed systems. As an application we obtain Minkowski measurability of Apollonian gaskets, provide explicit formulae of the…

Dynamical Systems · Mathematics 2017-02-10 Marc Kesseböhmer , Sabrina Kombrink

Recently, graph neural networks (GNNs) have been successfully applied to predicting molecular properties, which is one of the most classical cheminformatics tasks with various applications. Despite their effectiveness, we empirically…

Machine Learning · Computer Science 2023-03-14 Su Kim , Dongha Lee , SeongKu Kang , Seonghyeon Lee , Hwanjo Yu

Local structure characterization with the bond-orientational order parameters q4, q6, ... introduced by Steinhardt et al. has become a standard tool in condensed matter physics, with applications including glass, jamming, melting or…

Soft Condensed Matter · Physics 2014-02-10 Walter Mickel , Sebastian C. Kapfer , Gerd E. Schröder-Turk , Klaus Mecke

Molecular featurisation refers to the transformation of molecular data into numerical feature vectors. It is one of the key research areas in molecular machine learning and computational drug discovery. Recently, message-passing graph…

Machine Learning · Computer Science 2024-11-22 Markus Dablander

We propose a new method to numerically compute the $\mathbb{Z}_2$ indices for disordered topological insulators in Kitaev's periodic table. All of the $\mathbb{Z}_2$ indices are known to be derived from the index formulae which are…

Mesoscale and Nanoscale Physics · Physics 2017-12-13 Yutaka Akagi , Hosho Katsura , Tohru Koma

Despite their importance in a wide variety of applications, the estimation of ionization cross sections for large molecules continues to present challenges for both experiment and theory. Machine learning algorithms have been shown to be an…

Atomic Physics · Physics 2024-11-25 A. L. Harris , J. Nepomuceno

We systematically study total reaction cross sections of carbon isotopes with N=6-16 on a proton target for wide range of incident energies, putting an emphasis on the difference from the case of a carbon target. The analysis includes the…

Nuclear Theory · Physics 2014-11-18 B. Abu-Ibrahim , W. Horiuchi , A. Kohama , Y. Suzuki

Graph Neural Networks (GNNs) have achieved strong results in molecular property prediction, but polymers present distinct challenges: labeled datasets are scarce and small (typically in the order of hundreds of polymers) due to the need for…

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