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We consider a discrete-time model for random interface growth which admits exact formulas and converges to the Polynuclear growth model in a particular limit. The height of the interface is initially flat and the evolution involves the…

Probability · Mathematics 2023-08-28 Will FitzGerald

It is known that when the diffuse interface thickness $\epsilon$ vanishes, the sharp interface limit of the stochastic reaction-diffusion equation is formally a stochastic geometric flow. To capture and simulate such geometric flow, it is…

Numerical Analysis · Mathematics 2024-05-16 Jianbo Cui , Liying Sun

We present a model for cell growth, division and packing under soft constraints that arise from the deformability of the cells as well as of a membrane that encloses them. Our treatment falls within the framework of diffuse interface…

Cell Behavior · Quantitative Biology 2019-01-09 J. Jiang , K. Garikipati , S. Rudraraju

Tumor growth has a number of features in common with a physical process known as molecular beam epitaxy. Both growth processes are characterized by the constraint of growth development to the body border, and surface diffusion of…

Quantitative Methods · Quantitative Biology 2009-11-13 Carlos Escudero

In this paper, we propose a tumor growth model to incorporate and investigate the spatial effects of autophagy. The cells are classified into two phases: normal cells and autophagic cells, whose dynamics are also coupled with the nutrients.…

Analysis of PDEs · Mathematics 2021-08-31 Xu'an Dou , Jian-Guo Liu , Zhennan Zhou

We consider the transmission eigenvalue problem for an impenetrable obstacle with Dirichlet boundary condition surrounded by a thin layer of non-absorbing inhomogeneous material. We derive a rigorous asymptotic expansion for the first…

Analysis of PDEs · Mathematics 2013-12-06 Fioralba Cakoni , Nicolas Chaulet , Houssem Haddar

Motivated by practical applications in heat conduction and contaminant transport, we consider heat and mass diffusion across a perturbed interface separating two finite regions of distinct diffusivity. Under the assumption of continuity of…

Biological Physics · Physics 2022-01-12 Elliot J. Carr , Dylan J. Oliver , Matthew J. Simpson

We propose a model for describing the growth on an untreated tumor, which is characterized in a simple way by a minimal number of parameters with a well-defined physical interpretation. The model is motivated by invoking the Master Equation…

Populations and Evolution · Quantitative Biology 2007-05-23 José F. Nieves , Marcelo R. Ubriaco

We consider a degenerate partial differential equation arising in population dynamics, namely the porous medium equation with a bistable reaction term. We study its asymptotic behavior as a small parameter, related to the thickness of a…

Analysis of PDEs · Mathematics 2011-07-19 Matthieu Alfaro , Danielle Hilhorst

Motivated by the incompressible limit of a cell density model, we propose a free boundary tumor growth model where the pressure satisfies an obstacle problem on an evolving domain $\Omega(t)$, and the coincidence set $\Lambda(t)$ captures…

Analysis of PDEs · Mathematics 2023-11-01 Xu'an Dou , Chengfeng Shen , Zhennan Zhou

With the aim to characterize the formation and propagation of bulges in cylindrical rubber balloons, we carry out an expansion of the non-linear axisymmetric membrane model assuming slow axial variations. We obtain a diffuse interface model…

Classical Physics · Physics 2018-11-14 Claire Lestringant , Basile Audoly

A new approach is developed to derive an analytical form for mobility corrections in phase-field models for pure material solidification. Similar to the thin interface limit approach (Karma and Rappel, 1996) it seeks to remove systematic…

Computational Physics · Physics 2019-05-09 Stephan Hubig , Raphael Schiedung , Ingo Steinbach

We develop a computational method for simulating the nonlinear dynamics of an elastic tumor-host interface. This work is motivated by the recent linear stability analysis of a two-phase tumor model with an elastic membrane interface in 2D.…

Numerical Analysis · Mathematics 2019-12-12 Min-Jhe Lu , Chun Liu , Shuwang Li

We introduce a diffuse interface box method (DIBM) for the numerical approximation on complex geometries of elliptic problems with Dirichlet boundary conditions. We derive a priori $H^1$ and $L^2$ error estimates highlighting the r\^{o}le…

Numerical Analysis · Mathematics 2021-04-27 G. Negrini , N. Parolini , M. Verani

We present the microscopic equation of growing interface with quenched noise for the Tang and Leschhorn model [{\em Phys. Rev.} {\bf A 45}, R8309 (1992)]. The evolution equations for the mean heigth and the roughness are reached in a simple…

Statistical Mechanics · Physics 2015-06-25 L. A. Braunstein , R. C. Buceta , A. Diaz-Sanchez

This article completes the study of the influence of the intensity parameter $\alpha$ in the boundary condition $\varepsilon \partial_{\boldsymbol{\nu}_\varepsilon} u_\varepsilon - u_\varepsilon \,…

Analysis of PDEs · Mathematics 2024-06-24 Taras Mel'nyk , Christian Rohde

We study a free boundary problem modelling the growth of non-necrotic tumors with fluid-like tissues. The fluid velocity satisfies Stokes equations with a source determined by the proliferation rate of tumor cells which depends on the…

Analysis of PDEs · Mathematics 2008-06-10 Junde Wu , Shangbin Cui

The effective dilatational and shear viscosities of a particle-laden fluid interface are computed in the dilute limit under the assumption of an asymptotically vanishing viscosity ratio between both fluids. Spherical particles with a given…

Fluid Dynamics · Physics 2020-10-28 Michael Eigenbrod , Steffen Hardt

We consider the sharp interface limit of a convective Allen-Cahn equation, which can be part of a Navier-Stokes/Allen-Cahn system, for different scalings of the mobility $m_\varepsilon=m_0\varepsilon^\theta$ as $\varepsilon\to 0$. In the…

Analysis of PDEs · Mathematics 2021-02-22 Helmut Abels

We study a diffusion approximation for a model of stochastic motion of a particle in one spatial dimension. The velocity of the particle is constant but the direction of the motion undergoes random changes with a Poisson clock. Moreover,…

Functional Analysis · Mathematics 2022-04-21 Adam Bobrowski , Tomasz Komorowski
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