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It is well known that the kinetics of an intracellular biochemical network is stochastic. This is due to intrinsic noise arising from the random timing of biochemical reactions in the network as well as due to extrinsic noise stemming from…

Subcellular Processes · Quantitative Biology 2019-06-05 Emma M. Keizer , Bjorn Bastian , Robert W. Smith , Ramon Grima , Christian Fleck

Neurons and networks in the cerebral cortex must operate reliably despite multiple sources of noise. To evaluate the impact of both input and output noise, we determine the robustness of single-neuron stimulus selective responses, as well…

Neurons and Cognition · Quantitative Biology 2018-01-24 Ran Rubin , L. F. Abbott , Haim Sompolinsky

We analyze a class of chemical reaction networks under mass-action kinetics and involving multiple time-scales, whose deterministic and stochastic models display qualitative differences. The networks are inspired by gene-regulatory…

Molecular Networks · Quantitative Biology 2018-01-30 Tomislav Plesa , Radek Erban , Hans G. Othmer

We propose a stochastic dynamical model of noisy neural networks with complex architectures and discuss activation of neural networks by a stimulus, pacemakers and spontaneous activity. This model has a complex phase diagram with…

Disordered Systems and Neural Networks · Physics 2015-05-13 A. V. Goltsev , F. V. de Abreu , S. N. Dorogovtsev , J. F. F. Mendes

The impressive performance of artificial neural networks has come at the cost of high energy usage and CO$_2$ emissions. Unconventional computing architectures, with magnetic systems as a candidate, have potential as alternative…

Emerging Technologies · Computer Science 2023-03-06 Matthew O. A. Ellis , Alex Welbourne , Stephan J. Kyle , Paul W. Fry , Dan A. Allwood , Thomas J. Hayward , Eleni Vasilaki

Understanding the principles that govern dynamical systems is a central challenge across many scientific domains, including biology and ecology. Incomplete knowledge of nonlinear interactions and stochastic effects often renders bottom-up…

Machine Learning · Computer Science 2025-11-18 Gianluigi Pillonetto , Alberto Giaretta , Mauro Bisiacco

A general class of dynamical systems which can be trained to operate in classification and generation modes are introduced. A procedure is proposed to plant asymptotic stationary attractors of the deterministic model. Optimizing the…

Disordered Systems and Neural Networks · Physics 2025-10-15 Stefano Gagliani , Feliciano Giuseppe Pacifico , Lorenzo Chicchi , Duccio Fanelli , Diego Febbe , Lorenzo Buffoni , Raffaele Marino

A steadily increasing body of evidence suggests that the brain performs probabilistic inference to interpret and respond to sensory input and that trial-to-trial variability in neural activity plays an important role. The neural sampling…

Neurons and Cognition · Quantitative Biology 2017-07-07 Ilja Bytschok , Dominik Dold , Johannes Schemmel , Karlheinz Meier , Mihai A. Petrovici

Winner-take-all (WTA) networks constitute a central circuit motif in cortical networks of the brain. In addition, WTA-like activations are abundant in modern deep learning models in the form of the softmax activation for example in…

Machine Learning · Computer Science 2026-05-22 Julian Gutheil , Simon Hitzginger , Robert Legenstein

In this article, we propose a novel Winner-Take-All (WTA) architecture employing neurons with nonlinear dendrites and an online unsupervised structural plasticity rule for training it. Further, to aid hardware implementations, our network…

Neural and Evolutionary Computing · Computer Science 2015-12-07 Subhrajit Roy , Arindam Basu

We consider the general problem of describing the dynamics of subnetworks of larger biochemical reaction networks, e.g. protein interaction networks involving complex formation and dissociation reactions. We propose the use of model…

Quantitative Methods · Quantitative Biology 2020-08-26 Barbara Bravi , Katy J. Rubin , Peter Sollich

We consider a generic class of gene circuits affected by nonlinear extrinsic noise. To address this nonlinearity we introduce a general perturbative methodology based on assuming timescale separation between noise and genes dynamics, with…

Molecular Networks · Quantitative Biology 2023-05-10 Gerardo Aquino , Andrea Rocco

Recursive Neural Networks are non-linear adaptive models that are able to learn deep structured information. However, these models have not yet been broadly accepted. This fact is mainly due to its inherent complexity. In particular, not…

Neural and Evolutionary Computing · Computer Science 2009-11-18 Alejandro Chinea

Neurons in the nervous system are submitted to distinct sources of noise, such as ionic-channel and synaptic noise, which introduces variability in their responses to repeated presentations of identical stimuli. This motivates the use of…

A stochastic model of excitatory and inhibitory interactions which bears universality traits is introduced and studied. The endogenous component of noise, stemming from finite size corrections, drives robust inter-nodes correlations, that…

Disordered Systems and Neural Networks · Physics 2017-08-16 Clement Zankoc , Duccio Fanelli , Francesco Ginelli , Roberto Livi

Gene regulatory networks can be successfully modeled as Boolean networks. A much discussed hypothesis says that such model networks reproduce empirical findings the best if they are tuned to operate at criticality, i.e. at the borderline…

Molecular Networks · Quantitative Biology 2016-10-12 Pablo Villegas , José Ruiz-Franco , Jorge Hidalgo , Miguel A. Muñoz

Living systems implement and execute an extraordinary plethora of computational tasks. The inherent degree of large scale coordination emerges as a global property, from the intricate sea of microscopic interactions. The brain, with its…

Disordered Systems and Neural Networks · Physics 2018-01-03 Duccio Fanelli , Francesco Ginelli , Roberto Livi , Niccolò Zagli , Clement Zankoc

How can we efficiently propagate uncertainty in a latent state representation with recurrent neural networks? This paper introduces stochastic recurrent neural networks which glue a deterministic recurrent neural network and a state space…

Machine Learning · Statistics 2016-11-15 Marco Fraccaro , Søren Kaae Sønderby , Ulrich Paquet , Ole Winther

A growing body of research indicates that structural plasticity mechanisms are crucial for learning and memory consolidation. Starting from a simple phenomenological model, we exploit a mean-field approach to develop a theoretical framework…

Neurons and Cognition · Quantitative Biology 2024-06-19 Gianmarco Tiddia , Luca Sergi , Bruno Golosio

We present a novel framework for central pattern generator design that leverages the intrinsic rebound excitability of neurons in combination with winner-takes-all computation. Our approach unifies decision-making and rhythmic pattern…

Systems and Control · Electrical Eng. & Systems 2025-04-16 Yongkang Huo , Fuvio Forni , Rodolphe Sepulchre