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Large genomic datasets are now created through numerous activities, including recreational genealogical investigations, biomedical research, and clinical care. At the same time, genomic data has become valuable for reuse beyond their…

Cryptography and Security · Computer Science 2021-12-28 Rajagopal Venkatesaramani , Zhiyu Wan , Bradley A. Malin , Yevgeniy Vorobeychik

DNA sequencing is becoming increasingly commonplace, both in medical and direct-to-consumer settings. To promote discovery, collected genomic data is often de-identified and shared, either in public repositories, such as OpenSNP, or with…

Machine Learning · Computer Science 2022-12-21 Rajagopal Venkatesaramani , Bradley A. Malin , Yevgeniy Vorobeychik

Searching for local sequence patterns is one of the basic tasks in bioinformatics. Sequence patterns might have structural, functional or some other relevance, and numerous methods have been developed to detect and analyze them. These…

Quantitative Methods · Quantitative Biology 2018-08-01 Braslav Rabar , Strahil Ristov , Maja Zagorščak , Martin Rosenzweig , Pavle Goldstein

Generative Adversarial Networks (GANs) have demonstrated their ability to generate synthetic samples that match a target distribution. However, from a privacy perspective, using GANs as a proxy for data sharing is not a safe solution, as…

Motivated by the growing availability of personal genomics services, we study an information-theoretic privacy problem that arises when sharing genomic data: a user wants to share his or her genome sequence while keeping the genotypes at…

Information Theory · Computer Science 2021-10-18 Fangwei Ye , Hyunghoon Cho , Salim El Rouayheb

Due to the pervasiveness of image capturing devices in every-day life, images of individuals are routinely captured. Although this has enabled many benefits, it also infringes on personal privacy. A promising direction in research on…

Cryptography and Security · Computer Science 2021-02-23 William Croft , Jörg-Rüdiger Sack , Wei Shi

Machine learning (ML) methods have been widely used in genomic studies. However, genomic data are often held by different stakeholders (e.g. hospitals, universities, and healthcare companies) who consider the data as sensitive information,…

Cryptography and Security · Computer Science 2020-03-03 Cheng Hong , Zhicong Huang , Wen-jie Lu , Hunter Qu , Li Ma , Morten Dahl , Jason Mancuso

We focus on the problem of generating high-quality, private synthetic glucose traces, a task generalizable to many other time series sources. Existing methods for time series data synthesis, such as those using Generative Adversarial…

Machine Learning · Computer Science 2023-11-01 Josephine Lamp , Mark Derdzinski , Christopher Hannemann , Joost van der Linden , Lu Feng , Tianhao Wang , David Evans

Splitting a literal genomic sequence into 4 binary files is enough to ensure confidentiality and integrity during storage and transfer of information. The binary files are resources for RSA or one-time-pad (OTP) cryptography protocols. It…

Cryptography and Security · Computer Science 2020-03-13 Guy Dodin

Sequential recommendation has attracted a lot of attention from both academia and industry, however the privacy risks associated to gathering and transferring users' personal interaction data are often underestimated or ignored. Existing…

Information Retrieval · Computer Science 2024-01-10 Wei Wang , Yujie Lin , Pengjie Ren , Zhumin Chen , Tsunenori Mine , Jianli Zhao , Qiang Zhao , Moyan Zhang , Xianye Ben , Yujun Li

We develop statistically based methods to detect single nucleotide DNA mutations in next generation sequencing data. Sequencing generates counts of the number of times each base was observed at hundreds of thousands to billions of genome…

Applications · Statistics 2012-10-01 Omkar Muralidharan , Georges Natsoulis , John Bell , Hanlee Ji , Nancy R. Zhang

We propose an assembly algorithm {\sc Barnacle} for sequences generated by the clone-based approach. We illustrate our approach by assembling the human genome. Our novel method abandons the original physical-mapping-first framework. As we…

Data Structures and Algorithms · Computer Science 2007-05-23 Vicky Choi , Martin Farach-Colton

Generative Adversarial Network (GAN) and its variants have shown promising results in generating synthetic data. However, the issues with GANs are: (i) the learning happens around the training samples and the model often ends up remembering…

Computer Vision and Pattern Recognition · Computer Science 2020-09-30 Saurabh Gupta , Arun Balaji Buduru , Ponnurangam Kumaraguru

In recent years, Whole Genome Sequencing (WGS) evolved from a futuristic-sounding research project to an increasingly affordable technology for determining complete genome sequences of complex organisms, including humans. This prompts a…

Cryptography and Security · Computer Science 2015-02-17 Erman Ayday , Emiliano De Cristofaro , Jean-Pierre Hubaux , Gene Tsudik

Repetitive DNA (repeats) poses significant challenges for accurate and efficient genome assembly and sequence alignment. This is particularly true for metagenomic data, where genome dynamics such as horizontal gene transfer, gene…

Machine Learning · Computer Science 2024-02-15 Ali Azizpour , Advait Balaji , Todd J. Treangen , Santiago Segarra

The success of deep learning based face recognition systems has given rise to serious privacy concerns due to their ability to enable unauthorized tracking of users in the digital world. Existing methods for enhancing privacy fail to…

Computer Vision and Pattern Recognition · Computer Science 2023-06-21 Fahad Shamshad , Muzammal Naseer , Karthik Nandakumar

Protecting sensitive information against data exploiting attacks is an emerging research area in data mining. Over the past, several different methods have been introduced to protect individual privacy from such attacks while maximizing…

Cryptography and Security · Computer Science 2021-07-29 Hung Nguyen , Di Zhuang , Pei-Yuan Wu , Morris Chang

Photos of faces uploaded online are vulnerable to malicious actors who can scrape facial images from online sources and intrude on personal privacy via unauthorized use of facial recognition models. This paper presents FaceCloak, a novel…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Zachary Yahn , Fatih Ilhan , Tiansheng Huang , Selim Tekin , Sihao Hu , Yichang Xu , Margaret Loper , Ling Liu

Gene annotation has traditionally required direct comparison of DNA sequences between an unknown gene and a database of known ones using string comparison methods. However, these methods do not provide useful information when a gene does…

Machine Learning · Computer Science 2019-09-17 James K. Senter , Taylor M. Royalty , Andrew D. Steen , Amir Sadovnik

Federated learning is considered as an effective privacy-preserving learning mechanism that separates the client's data and model training process. However, federated learning is still under the risk of privacy leakage because of the…

Machine Learning · Computer Science 2022-06-03 Yuxuan Wan , Han Xu , Xiaorui Liu , Jie Ren , Wenqi Fan , Jiliang Tang