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We propose a new empirical Bayes method for covariate-assisted multiple testing with false discovery rate (FDR) control, where we model the local false discovery rate for each hypothesis as a function of both its covariates and p-value. Our…

Methodology · Statistics 2021-07-01 Patrick Chao , William Fithian

Likelihood ratio tests are a widely used method in global analyses in particle physics. The computation of the statistical significance (p-value) of these tests is usually done with a simple formula that relies on Wilks' theorem. There are,…

High Energy Physics - Phenomenology · Physics 2013-08-21 Martin Wiebusch

Semi-supervised learning leverages unlabeled data to enhance model performance, addressing the limitations of fully supervised approaches. Among its strategies, pseudo-supervision has proven highly effective, typically relying on one or…

Computer Vision and Pattern Recognition · Computer Science 2025-05-13 Negin Ghamsarian , Sahar Nasirihaghighi , Klaus Schoeffmann , Raphael Sznitman

In many practical applications of multiple hypothesis testing using the False Discovery Rate (FDR), the given hypotheses can be naturally partitioned into groups, and one may not only want to control the number of false discoveries (wrongly…

Methodology · Statistics 2016-11-01 Rina Foygel Barber , Aaditya Ramdas

Precision medicine emerges as the most important contemporary paradigm shift of medical practice but has several challenges in evidence formation and implementation for clinical practice. Precision/Personalized evidence-based medicine…

Other Quantitative Biology · Quantitative Biology 2015-12-15 Maani Beigy

Traditional Linear Genetic Programming (LGP) algorithms are based only on the selection mechanism to guide the search. Genetic operators combine or mutate random portions of the individuals, without knowing if the result will lead to a…

Neural and Evolutionary Computing · Computer Science 2017-04-05 Léo Françoso Dal Piccol Sotto , Vinícius Veloso de Melo

We develop an empirical Bayes (EB) G-modeling framework for short-panel linear models with nonparametric prior for the random intercepts, slopes, dynamics, and non-spherical error variances. We establish identification and consistency of…

Econometrics · Economics 2026-02-13 Myunghyun Song , Sokbae Lee , Serena Ng

Valid online inference is an important problem in contemporary multiple testing research,to which various solutions have been proposed recently. It is well-known that these existing methods can suffer from a significant loss of power if the…

Methodology · Statistics 2023-01-16 Sebastian Döhler , Iqraa Meah , Etienne Roquain

Researchers in data-rich disciplines---think of computational genomics and observational cosmology---often wish to mine large bodies of $p$-values looking for significant effects, while controlling the false discovery rate or family-wise…

Methodology · Statistics 2017-06-20 Edgar Dobriban

We study nonparametric estimation of univariate cumulative distribution functions (CDFs) pertaining to data missing at random. The proposed estimators smooth the inverse probability weighted (IPW) empirical CDF with the Bernstein operator,…

Statistics Theory · Mathematics 2026-03-30 Rihab Gharbi , Wissem Jedidi , Salah Khardani , Frédéric Ouimet

Linear models are foundational tools in statistics and ubiquitous across the applied sciences. However, conventional statistical inference -- such as $t$-tests and $F$-tests -- are only valid at fixed sample sizes, making them unsuitable…

Methodology · Statistics 2025-07-08 Michael Lindon , Dae Woong Ham , Martin Tingley , Iavor Bojinov

The effectiveness of active learning largely depends on the sampling efficiency of the acquisition function. Expected Loss Reduction (ELR) focuses on a Bayesian estimate of the reduction in classification error, and more general costs fit…

Machine Learning · Computer Science 2023-12-19 Wei Tan , Lan Du , Wray Buntine

Consider a random vector $(X,Y)$ and let $m(x)=E(Y|X=x)$. We are interested in testing $H_0:m\in {\cal M}_{\Theta,{\cal G}}=\{\gamma(\cdot,\theta,g):\theta \in \Theta,g\in {\cal G}\}$ for some known function $\gamma$, some compact set…

Statistics Theory · Mathematics 2008-07-16 Ingrid Van Keilegom , César Sánchez Sellero , Wenceslao González Manteiga

In large scale multiple testing, the use of an empirical null distribution rather than the theoretical null distribution can be critical for correct inference. This paper proposes a ``mode matching'' method for fitting an empirical null…

Applications · Statistics 2009-01-27 Armin Schwartzman

Consider the problem of testing multiple null hypotheses. A classical approach to dealing with the multiplicity problem is to restrict attention to procedures that control the familywise error rate ($FWER$), the probability of even one…

Statistics Theory · Mathematics 2007-06-13 Joseph P. Romano , Azeem M. Shaikh

In recent years, multiple hypothesis testing has come to the forefront of statistical research, ostensibly in relation to applications in genomics and some other emerging fields. The false discovery rate (FDR) and its variants provide very…

Statistics Theory · Mathematics 2008-12-18 Subhashis Ghosal , Anindya Roy , Yongqiang Tang

This paper introduces an approach for detecting differences in the first-order structures of spatial point patterns. The proposed approach leverages the kernel mean embedding in a novel way by introducing its approximate version tailored to…

Methodology · Statistics 2020-06-15 Raif M. Rustamov , James T. Klosowski

In this paper, we address conditional testing problems through the conformal inference framework. We define the localized conformal p-values by inverting prediction intervals and prove their theoretical properties. These defined p-values…

Methodology · Statistics 2024-09-26 Xiaoyang Wu , Lin Lu , Zhaojun Wang , Changliang Zou

A new standard is proposed for the evidential assessment of replication studies. The approach combines a specific reverse-Bayes technique with prior-predictive tail probabilities to define replication success. The method gives rise to a…

Methodology · Statistics 2022-11-08 Leonhard Held

We build a valid p-value based on a concentration inequality for bounded random variables introduced by Pelekis, Ramon and Wang. The motivation behind this work is the calibration of predictive algorithms in a distribution-free setting. The…

Machine Learning · Statistics 2024-05-16 Joaquin Alvarez
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