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MEG and EEG are noninvasive functional neuroimaging techniques that provide recordings of brain activity with high temporal resolution, and thus provide a unique window to study fast time-scale neural dynamics in humans. However, the…

Applications · Statistics 2015-11-13 Camilo Lamus , Matti S. Hamalainen , Emery N. Brown , Patrick L. Purdon

MEG/EEG are non-invasive imaging techniques that record brain activity with high temporal resolution. However, estimation of brain source currents from surface recordings requires solving an ill-posed inverse problem. Converging lines of…

We provide an overview of the state-of-the-art for mathematical methods that are used to reconstruct brain activity from neurophysiological data. After a brief introduction on the mathematics of the forward problem, we discuss standard and…

Quantitative Methods · Quantitative Biology 2017-05-09 Alberto Sorrentino , Michele Piana

We focus on electromagnetoencephalography imaging of the neural activity and, in particular, finding a robust estimate for the primary current distribution via the hierarchical Bayesian model (HBM). Our aim is to develop a reasonably fast…

Numerical Analysis · Mathematics 2020-02-24 Atena Rezaei , Alexandra Koulouri , Sampsa Pursiainen

A central goal in many brain studies is the identification of those brain regions that are activated during an observation window that may correspond to a motor task, a stimulus, or simply a resting state. While functional MRI is currently…

Numerical Analysis · Mathematics 2025-10-23 Daniela Calvetti , Erkki Somersalo

Source imaging based on magnetoencephalography (MEG) and electroencephalography (EEG) allows for the non-invasive analysis of brain activity with high temporal and good spatial resolution. As the bioelectromagnetic inverse problem is…

Applications · Statistics 2016-07-29 Daniel Strohmeier , Yousra Bekhti , Jens Haueisen , Alexandre Gramfort

Bayesian modeling and analysis of the MEG and EEG modalities provide a flexible framework for introducing prior information complementary to the measured data. This prior information is often qualitative in nature, making the translation of…

Mathematical Physics · Physics 2008-11-20 Daniela Calvetti , Harri Hakula , Sampsa Pursiainen , Erkki Somersalo

Current non-invasive neuroimaging techniques trade off between spatial resolution and temporal resolution. While magnetoencephalography (MEG) can capture rapid neural dynamics and functional magnetic resonance imaging (fMRI) can spatially…

Neurons and Cognition · Quantitative Biology 2025-10-13 Beige Jerry Jin , Leila Wehbe

Neuroradiologists and neurosurgeons increasingly opt to use functional magnetic resonance imaging (fMRI) to map functionally relevant brain regions for noninvasive presurgical planning and intraoperative neuronavigation. This application…

Methodology · Statistics 2023-06-07 Andrew S. Whiteman , Andreas J. Bartsch , Jian Kang , Timothy D. Johnson

Magnetoencephalography (MEG) is a noninvasive method for measuring magnetic flux signals caused by brain activity using sensor arrays located on or above the scalp. A common strategy for monitoring brain activity is to place sensors on a…

Medical Physics · Physics 2022-05-24 Wan-Jin Yeo , Samu Taulu , J. Nathan Kutz

This thesis is dedicated to the statistical analysis of multi-sub ject fMRI data, with the purpose of identifying bain structures involved in certain cognitive or sensori-motor tasks, in a reproducible way across sub jects. To overcome…

Applications · Statistics 2010-05-19 Merlin Keller , Alexis Roche , Marc Lavielle

We present a new approach to the electromagnetic inverse problem that explicitly addresses the ambiguity associated with its ill-posed character. Rather than calculating a single ``best'' solution according to some criterion, our approach…

Neurons and Cognition · Quantitative Biology 2007-05-23 David M. Schmidt , John S. George , C. C. Wood

Subcortical structures play a critical role in brain function. However, options for assessing electrophysiological activity in these structures are limited. Electromagnetic fields generated by neuronal activity in subcortical structures can…

This paper is concerned with variational and Bayesian approaches to neuro-electromagnetic inverse problems (EEG and MEG). The strong indeterminacy of these problems is tackled by introducing sparsity inducing regularization/priors in a…

Signal Processing · Electrical Eng. & Systems 2023-06-28 Samy Mokhtari , Jean-Michel Badier , Christian G. Bénar , Bruno Torrésani

This report introduces a new hierarchical Bayesian model for the EEG source localization problem. This model promotes structured sparsity to search for focal brain activity. This sparsity is obtained via a multivariate Bernoulli Laplacian…

Methodology · Statistics 2015-09-16 Facundo Costa , Hadj Batatia , Thomas Oberlin , Jean-Yves Tourneret

Experiments that study neural encoding of stimuli at the level of individual neurons typically choose a small set of features present in the world --- contrast and luminance for vision, pitch and intensity for sound --- and assemble a…

Machine Learning · Statistics 2016-11-22 Xin , Chen , Jeffrey M Beck , John M Pearson

Objective: Sparse Bayesian learning provides an effective scheme to solve the high-dimensional problem in brain signal decoding. However, traditional assumptions regarding data distributions such as Gaussian and binomial are potentially…

Signal Processing · Electrical Eng. & Systems 2025-08-19 Yuanhao Li , Badong Chen , Wenjun Bai , Yasuharu Koike , Okito Yamashita

The MagnetoEncephaloGraphy (MEG) has gained great interest in neurorehabilitation training due to its high temporal resolution. The challenge is to localize the active regions of the brain in a fast and accurate way. In this paper we use an…

Medical Physics · Physics 2016-10-07 Annalisa Pascarella , Francesca Pitolli

Identifying the functional networks underpinning indirectly observed processes poses an inverse problem for neurosciences or other fields. A solution of such inverse problems estimates as a first step the activity emerging within functional…

M/EEG source localization is an open research issue. To solve it, it is important to have good knowledge of several physical parameters to build a reliable head operator. Amongst them, the value of the conductivity of the human skull has…

Methodology · Statistics 2017-01-06 Facundo Costa , Hadj Batatia , Thomas Oberlin , Jean-Yves Tourneret
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