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In genetic association studies, rare variants with extremely small allele frequency play a crucial role in complex traits, and the set-based testing methods that jointly assess the effects of groups of single nucleotide polymorphisms (SNPs)…

Methodology · Statistics 2020-03-13 Shonosuke Sugasawa , Hisashi Noma

The network representation is becoming increasingly popular for the description of cardiovascular interactions based on the analysis of multiple simultaneously collected variables. However, the traditional methods to assess network links…

In this paper we propose a Multiple kernel testing procedure to infer survival data when several factors (e.g. different treatment groups, gender, medical history) and their interaction are of interest simultaneously. Our method is able to…

Methodology · Statistics 2022-06-16 Marc Ditzhaus , Tamara Fernández , Nicolás Rivera

Higher-order interactions underlie complex phenomena in systems such as biological and artificial neural networks, but their study is challenging due to the scarcity of tractable models. By leveraging a generalisation of the maximum entropy…

Disordered Systems and Neural Networks · Physics 2025-12-10 Miguel Aguilera , Pablo A. Morales , Fernando E. Rosas , Hideaki Shimazaki

Identifying relationships between molecular variations and their clinical presentations has been challenged by the heterogeneous causes of a disease. It is imperative to unveil the relationship between the high dimensional molecular…

Methodology · Statistics 2021-09-02 Wennan Chang , Changlin Wan , Yong Zang , Chi Zhang , Sha Cao

Molecular interactions often involve high-order relationships that cannot be fully captured by traditional graph-based models limited to pairwise connections. Hypergraphs naturally extend graphs by enabling multi-way interactions, making…

Machine Learning · Computer Science 2025-05-12 Tien Dang , Truong-Son Hy

Higher-order learning is fundamentally rooted in exploiting compositional features. It clearly hinges on enriching the representation by more elaborate interactions of the data which, in turn, tends to increase the model complexity of…

Computer Vision and Pattern Recognition · Computer Science 2026-04-17 Haoyu Yun , Hamid Krim , Yufang Bao

Systems of interacting particles or agents have wide applications in many disciplines such as Physics, Chemistry, Biology and Economics. These systems are governed by interaction laws, which are often unknown: estimating them from…

Machine Learning · Statistics 2020-07-16 Fei Lu , Mauro Maggioni , Sui Tang

Change-point analysis plays a significant role in various fields to reveal discrepancies in distribution in a sequence of observations. While a number of algorithms have been proposed for high-dimensional data, kernel-based methods have not…

Methodology · Statistics 2023-01-10 Hoseung Song , Hao Chen

Recent technological advances have introduced new high-throughput methods for studying host-virus interactions, but testing synergistic interactions between host gene pairs during infection remains relatively slow and labor intensive.…

Humans are sophisticated at reading interlocutors' emotions from multimodal signals, such as speech contents, voice tones and facial expressions. However, machines might struggle to understand various emotions due to the difficulty of…

Artificial Intelligence · Computer Science 2022-12-21 Feng Qiu , Wanzeng Kong , Yu Ding

The measure between heterogeneous data is still an open problem. Many research works have been developed to learn a common subspace where the similarity between different modalities can be calculated directly. However, most of existing…

Computer Vision and Pattern Recognition · Computer Science 2020-01-08 Jun Yu , Xiao-Jun Wu

Multimodal imaging has transformed neuroscience research. While it presents unprecedented opportunities, it also imposes serious challenges. Particularly, it is difficult to combine the merits of the interpretability attributed to a simple…

Methodology · Statistics 2021-11-25 Xiaowu Dai , Lexin Li

Nowadays, hyperspectral image classification widely copes with spatial information to improve accuracy. One of the most popular way to integrate such information is to extract hierarchical features from a multiscale segmentation. In the…

Computer Vision and Pattern Recognition · Computer Science 2016-06-17 Yanwei Cui , Laetitia Chapel , Sébastien Lefèvre

This paper presents a streamlined image analysis framework for correlating behavioral measures to anatomical measures on the cortex and detecting the regions of abnormal brain-behavior correlates. We correlated a facial emotion…

Neurons and Cognition · Quantitative Biology 2025-07-02 Moo K. Chung , Kim M. Dalton , Daniel J. Kelley , Richard J. Davidson

Kernel spectral clustering corresponds to a weighted kernel principal component analysis problem in a constrained optimization framework. The primal formulation leads to an eigen-decomposition of a centered Laplacian matrix at the dual…

Social and Information Networks · Computer Science 2014-12-03 Raghvendra Mall , Rocco Langone , Johan A. K. Suykens

Accurately characterizing higher-order interactions of brain regions and extracting interpretable organizational patterns from Functional Magnetic Resonance Imaging data is crucial for brain disease diagnosis. Current graph-based deep…

Neurons and Cognition · Quantitative Biology 2026-03-16 Dengyi Zhao , Zhiheng Zhou , Guiying Yan , Dongxiao Yu , Xingqin Qi

In the last few decades, significant achievements have been attained in predicting where humans look at images through different computational models. However, how to determine contributions of different visual features to overall saliency…

Computer Vision and Pattern Recognition · Computer Science 2013-07-23 Yasin Kavak , Erkut Erdem , Aykut Erdem

Multi-view diabetic retinopathy (DR) detection has recently emerged as a promising method to address the issue of incomplete lesions faced by single-view DR. However, it is still challenging due to the variable sizes and scattered locations…

Image and Video Processing · Electrical Eng. & Systems 2025-03-26 Yongting Hu , Yuxin Lin , Chengliang Liu , Xiaoling Luo , Xiaoyan Dou , Qihao Xu , Yong Xu

Background: The integration of multi-stain histopathology images through deep learning poses a significant challenge in digital histopathology. Current multi-modal approaches struggle with data heterogeneity and missing data. This study…

Computer Vision and Pattern Recognition · Computer Science 2024-09-27 Valentin Koch , Sabine Bauer , Valerio Luppberger , Michael Joner , Heribert Schunkert , Julia A. Schnabel , Moritz von Scheidt , Carsten Marr