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The delivery and assessment of quality health care is complex with many interacting and interdependent components. In terms of research design and statistical analysis, this complexity and interdependency makes it difficult to assess the…

Methodology · Statistics 2018-12-03 Maricela Cruz , Daniel L. Gillen , Miriam Bender , Hernando Ombao

We are sometimes forced to use the Interrupted Time Series (ITS) design as an identification strategy for potential policy change, such as when we only have a single treated unit and no comparable controls. For example, with recent county-…

Methodology · Statistics 2020-02-17 Luke Miratrix

While intelligent tutoring systems (ITSs) can use information from past students to personalize instruction, each new student is unique. Moreover, the education problem is inherently difficult because the learning process is only partially…

Machine Learning · Computer Science 2025-11-20 Jeffrey Jiang , Kevin Hong , Emily Kuczynski , Gregory Pottie

We study the problem of learning robust discriminative representations of causally related latent variables given the underlying causal graph and a training set comprising passively collected observational data and interventional data…

Machine Learning · Computer Science 2025-12-16 Gautam Sreekumar , Vishnu Naresh Boddeti

Irregularly sampled time series (ISTS) data has irregular temporal intervals between observations and different sampling rates between sequences. ISTS commonly appears in healthcare, economics, and geoscience. Especially in the medical…

Machine Learning · Computer Science 2020-10-27 Chenxi Sun , Shenda Hong , Moxian Song , Hongyan Li

Irregularly-sampled time series (ITS) are native to high-impact domains like healthcare, where measurements are collected over time at uneven intervals. However, for many classification problems, only small portions of long time series are…

Machine Learning · Computer Science 2023-02-09 Thomas Hartvigsen , Jidapa Thadajarassiri , Xiangnan Kong , Elke Rundensteiner

Many areas of research are characterised by the deluge of large-scale highly-dimensional time-series data. However, using the data available for prediction and decision making is hampered by the current lag in our ability to uncover and…

Artificial Intelligence · Computer Science 2020-11-24 Zina Ibrahim , Honghan Wu , Richard Dobson

Background: Interrupted time series analysis (ITSA) is widely used to evaluate health policy and intervention effects. While multiple-group ITSA (MG-ITSA) improves causal inference by incorporating a control group, residual confounding from…

Applications · Statistics 2026-04-28 Ariel Linden

Interrupted time series (ITS) is often used to evaluate the effectiveness of a health policy intervention that accounts for the temporal dependence of outcomes. When the outcome of interest is a percentage or percentile, the data can be…

Methodology · Statistics 2026-03-19 Shangyuan Ye , Maricela Cruz , Ziyou Wang , Yun Yu

We introduce DT-ICU, a multimodal digital twin framework for continuous risk estimation in intensive care. DT-ICU integrates variable-length clinical time series with static patient information in a unified multitask architecture, enabling…

Machine Learning · Computer Science 2026-01-13 Wen Guo

Missing data is a major challenge in clinical research. In electronic medical records, often a large fraction of the values in laboratory tests and vital signs are missing. The missingness can lead to biased estimates and limit our ability…

Machine Learning · Computer Science 2023-04-18 Omer Noy , Ron Shamir

Pragmatic trials increasingly define outcomes using real-world data such as electronic health records, where assessments are collected during routine care rather than at fixed timepoints. Consequently, these uncontrolled assessments may be…

Human interventions are a common source of data in autonomous systems during testing. These interventions provide an important signal about where the current policy needs improvement, but are often noisy and incomplete. We define Robust…

Machine Learning · Computer Science 2026-02-04 Ethan Pronovost , Khimya Khetarpal , Siddhartha Srinivasa

Measuring the effect of patient safety improvement efforts is needed to determine their value but is difficult due to the inherent complexities of hospital operations. In this paper, we show by case study how interrupted time series design…

Applications · Statistics 2018-06-28 Diego A. Martinez , Mehdi Jalalpour , David T. Efron , Scott R. Levin

Irregular Time Series Data (IRTS) has shown increasing prevalence in real-world applications. We observed that IRTS can be divided into two specialized types: Natural Irregular Time Series (NIRTS) and Accidental Irregular Time Series…

Machine Learning · Computer Science 2024-10-17 Liangwei Nathan Zheng , Zhengyang Li , Chang George Dong , Wei Emma Zhang , Lin Yue , Miao Xu , Olaf Maennel , Weitong Chen

Accurate and interpretable mortality risk prediction in intensive care units (ICUs) remains a critical challenge due to the irregular temporal structure of electronic health records (EHRs), the complexity of longitudinal disease…

Machine Learning · Computer Science 2026-03-10 Zahra Jafari , Azadeh Zamanifar , Amirfarhad Farhadi

Major postoperative complications are devastating to surgical patients. Some of these complications are potentially preventable via early predictions based on intraoperative data. However, intraoperative data comprise long and fine-grained…

Machine Learning · Computer Science 2022-10-11 Dingwen Li , Bing Xue , Christopher King , Bradley Fritz , Michael Avidan , Joanna Abraham , Chenyang Lu

Pervasive and ubiquitous computing facilitates immediate access to information in the sense of always-on. Information such as news, messages, or reminders can significantly enhance our daily routines but are rendered useless or disturbing…

Human-Computer Interaction · Computer Science 2022-12-20 Christoph Anderson , Judith Simone Heinisch , Shohreh Deldari , Flora D. Salim , Sandra Ohly , Klaus David , Veljko Pejovic

The paper algorithmizes the problem of regime change point identification for data measured in a system exhibiting impulsive behaviors. This is a fundamental challenge for annotation of measurement data relevant, e.g., for designing…

Intensive Care Units are complex, data-rich environments where critically ill patients are treated using variety of clinical equipment. The data collected using this equipment can be used clinical staff to gain insight into the condition of…

Human-Computer Interaction · Computer Science 2024-10-23 Marceli Wac , Raul Santos-Rodriguez , Chris McWilliams , Christopher Bourdeaux
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