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The paper highlights the role of a positive feedback gating mechanism at the cellular level in the robust- ness and modulation properties of rhythmic activities at the circuit level. The results are presented in the context of half-center…

Neurons and Cognition · Quantitative Biology 2014-12-22 Julie Dethier , Guillaume Drion , Alessio Franci , Rodolphe Sepulchre

Neuronal spiking exhibits an exquisite combination of modulation and robustness properties, rarely matched in artificial systems. We exploit the particular interconnection structure of conductance based models to investigate this remarkable…

Neurons and Cognition · Quantitative Biology 2013-11-12 Guillaume Drion , Alessio Franci , Vincent Seutin , Rodolphe Sepulchre

Small inhibitory neuronal circuits have long been identified as key neuronal motifs to generate and modulate the coexisting rhythms of various motor functions. Our paper highlights the role of a cellular switching mechanism to orchestrate…

Neurons and Cognition · Quantitative Biology 2018-02-20 Guillaume Drion , Alessio Franci , Rodolphe Sepulchre

Neuromorphic engineering makes use of mixed-signal analog and digital circuits to directly emulate the computational principles of biological brains. Such electronic systems offer a high degree of adaptability, robustness, and energy…

Systems and Control · Electrical Eng. & Systems 2026-04-09 Loris Mendolia , Chenxi Wen , Elisabetta Chicca , Giacomo Indiveri , Rodolphe Sepulchre , Jean-Michel Redouté , Alessio Franci

Bursting neurons fire rapid sequences of action potential spikes followed by a quiescent period. The basic dynamical mechanism of bursting is the slow currents that modulate a fast spiking activity caused by rapid ionic currents. Minimal…

Chaotic Dynamics · Physics 2015-02-16 Fabiano A. S. Ferrari , Ricardo L. Viana , Sérgio R. Lopes , Ruedi Stoop

Most models of neurons incorporate a capacitor to account for the marked capacitive behavior exhibited by the cell membrane. However, such capacitance is widely considered constant, thereby neglecting the possible effects of time-dependent…

Neurons and Cognition · Quantitative Biology 2025-12-29 Matías Courdurier , Leonel E. Medina , Esteban Paduro

The interplay of positive and negative feedback loops on different time scales appears to be a fundamental mechanisms for robust and tunable oscillations in both biological systems and electro-mechanical systems. We develop a detailed…

Systems and Control · Electrical Eng. & Systems 2021-04-06 Weiming Che , Fulvio Forni

Strongly coupled, recurrent, balanced network models have been successful in describing and predicting many phenomena observed in cortical neural recordings. However, most balanced network models use current-based synapse models in place of…

Neurons and Cognition · Quantitative Biology 2026-05-13 Vicky Zhu , Gabriel Ocker , Robert Rosenbaum

Robust stability and stochastic stability have separately seen intense study in control theory for many decades. In this work we establish relations between these properties for discrete-time systems and employ them for robust control…

Dynamical Systems · Mathematics 2020-04-20 Benjamin Gravell , Peyman Mohajerin Esfahani , Tyler Summers

Temporal modulation unlocks possibilities to dynamically control and modify the response of electromagnetic systems. Employing explicit dependencies of circuit or surface parameters on time enables the engineering of systems with…

Systems and Control · Electrical Eng. & Systems 2023-03-01 Grigorii Ptitcyn , Mohammad Sajjad Mirmoosa , Silvi Hrabar , Sergey Tretyakov

For a non-linear MIMO feedback system, the robustness against uncertain time-variations in the feedback loop is investigated in an input-output framework. A general sufficient condition in terms of a bound on average rates of time-variation…

Systems and Control · Electrical Eng. & Systems 2020-03-03 Yu-chen Sung , Sagar V. Patil , Michael G. Safonov

The spiking activity of neocortical neurons exhibits a striking level of variability, even when these networks are driven by identical stimuli. The approximately Poisson firing of neurons has led to the hypothesis that these neural networks…

Neurons and Cognition · Quantitative Biology 2023-12-29 Logan A. Becker , Baowang Li , Nicholas J. Priebe , Eyal Seidemann , Thibaud Taillefumier

We demonstrate a fully cryogenic microwave feedback network composed of modular superconducting devices connected by transmission lines and designed to control a mechanical oscillator coupled to one of the devices. The network features an…

For cellular biochemical reaction systems where the numbers of molecules is small, significant noise is associated with chemical reaction events. This molecular noise can give rise to behavior that is very different from the predictions of…

Molecular Networks · Quantitative Biology 2009-11-13 Matthew Scott , Terence Hwa , Brian Ingalls

This paper addresses the design of robust dynamic output feedback control for highly uncertain systems in which the unknown disturbance might be excited by the derivative of the control input. This context appears in many industrial…

Systems and Control · Computer Science 2016-10-20 Mazen Alamir , Jean Dobrowolski , Amgad tarek Mohammed

In this work we analyze and bound the effect of modeling errors on the stabilization of pure states or subspaces for quantum stochastic evolutions. Different approaches are used for open-loop and feedback control protocols. For both, we…

Quantum Physics · Physics 2024-09-27 Weichao Liang , Kentaro Ohki , Francesco Ticozzi

Motor systems show an overall robustness, but because they are highly nonlinear, understanding how they achieve robustness is difficult. In many rhythmic systems, robustness against perturbations involves response of both the shape and the…

Neurons and Cognition · Quantitative Biology 2022-05-18 Yangyang Wang , Jeffrey P. Gill , Hillel J. Chiel , Peter J. Thomas

Exploiting the specific structure of neuron conductance-based models, the paper investigates the mathematical modeling of neuronal bursting modulation. The proposed approach combines singularity theory and geometric singular perturbations…

Dynamical Systems · Mathematics 2013-11-28 Alessio Franci , Guillaume Drion , Rodolphe Sepulchre

The idea that information-processing systems operate near criticality to enhance computational performance is supported by scaling signatures in brain activity. However, external signals raise the question of whether this behavior is…

Neurons and Cognition · Quantitative Biology 2026-02-10 Rubén Calvo , Carles Martorell , Adrián Roig , Miguel A. Muñoz

Robust control design is mainly devoted to guarantee closed-loop stability of a model-based control law in presence of parametric and structural uncertainties. The control law is usually a complex feedback law which is derived from a…

Systems and Control · Computer Science 2011-08-12 Enrico Canuto , Wilber Acuna-Bravo , Andrés Molano-Jimenez , José Ospina , Carlos Perez-Montenegro
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