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Efficiently solving NP-complete problems-such as protein structure prediction, cryptographic decryption, and vulnerability detection-remains a central challenge in computer science. Traditional electronic computers, constrained by the…

Data Structures and Algorithms · Computer Science 2025-07-18 Jin Xu , XiaoLong Shi , Xin Chen , Fang Wang , Sirui Li , Pali Ye , Boliang Zhang , Di Deng , Zheng Kou , Xiaoli Qiang

While many systems have been developed to train Graph Neural Networks (GNNs), efficient model inference and evaluation remain to be addressed. For instance, using the widely adopted node-wise approach, model evaluation can account for up to…

Machine Learning · Computer Science 2022-11-29 Peiqi Yin , Xiao Yan , Jinjing Zhou , Qiang Fu , Zhenkun Cai , James Cheng , Bo Tang , Minjie Wang

DNA sequencing is revolutionising the field of medicine. DNA sequencers, the machines which perform DNA sequencing, have evolved from the size of a fridge to that of a mobile phone over the last two decades. The cost of sequencing a human…

Genomics · Quantitative Biology 2021-01-14 Hasindu Gamaarachchi

Oligonucleotide arrays are used in a wide range of genomic analyses, such as gene expression profiling, comparative genomic hybridization, chromatin immunoprecipitation, SNP detection, etc. During fabrication, the sites of an…

Emerging Technologies · Computer Science 2011-10-19 Dragos Trinca , Sanguthevar Rajasekaran

This paper presents GPU performance optimization and scaling results for inference models of the Sparse Deep Neural Network Challenge 2020. Demands for network quality have increased rapidly, pushing the size and thus the memory…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-09-04 Mert Hidayetoglu , Carl Pearson , Vikram Sharma Mailthody , Eiman Ebrahimi , Jinjun Xiong , Rakesh Nagi , Wen-Mei Hwu

A critical step of genome sequence analysis is the mapping of sequenced DNA fragments (i.e., reads) collected from an individual to a known linear reference genome sequence (i.e., sequence-to-sequence mapping). Recent works replace the…

Motivation: Low-complexity (LC) DNA sequences are compositionally repetitive sequences that are often associated with spurious homologous matches and variant calling artifacts. While algorithms for identifying LC sequences exist, they…

Genomics · Quantitative Biology 2025-11-18 Heng Li , Brian Li

Pairwise alignment of DNA sequencing data is a ubiquitous task in bioinformatics and typically represents a heavy computational burden. A standard approach to speed up this task is to compute "sketches" of the DNA reads (typically via…

Information Theory · Computer Science 2021-07-12 Ilan Shomorony , Govinda M. Kamath

We develop a dynamic dictionary data structure for the GPU, supporting fast insertions and deletions, based on the Log Structured Merge tree (LSM). Our implementation on an NVIDIA K40c GPU has an average update (insertion or deletion) rate…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-03-05 Saman Ashkiani , Shengren Li , Martin Farach-Colton , Nina Amenta , John D. Owens

Explosive growth in the amount of genomic data is matched by increasing power of consumer-grade computers. Even applications that require powerful servers can be quickly tested on desktop or laptop machines if we can generate representative…

Genomics · Quantitative Biology 2017-11-20 Anthony J. Greenberg

Recurrent Neural Networks (RNNs) are vital for sequential data processing. Long Short-Term Memory Autoencoders (LSTM-AEs) are particularly effective for unsupervised anomaly detection in time-series data. However, inherent sequential…

Hardware Architecture · Computer Science 2026-03-17 Aimilios Leftheriotis , Dimosthenis Masouros , Dimitrios Soudris , George Theodoridis

In this work we apply model averaging to parallel training of deep neural network (DNN). Parallelization is done in a model averaging manner. Data is partitioned and distributed to different nodes for local model updates, and model…

Machine Learning · Computer Science 2018-07-03 Hang Su , Haoyu Chen

This work presents a novel reconfigurable architecture for Low Latency Graph Neural Network (LL-GNN) designs for particle detectors, delivering unprecedented low latency performance. Incorporating FPGA-based GNNs into particle detectors…

Hardware Architecture · Computer Science 2024-01-19 Zhiqiang Que , Hongxiang Fan , Marcus Loo , He Li , Michaela Blott , Maurizio Pierini , Alexander Tapper , Wayne Luk

An efficient error reconciliation scheme is important for post-processing of quantum key distribution (QKD). Recently, a multi-matrix low-density parity-check codes based reconciliation algorithm which can provide remarkable perspectives…

Quantum Physics · Physics 2020-01-23 Yu Guo , Chaohui Gao , Dong Jiang , Lijun Chen

Recent advances in next-generation sequencing technologies have facilitated the use of deoxyribonucleic acid (DNA) as a novel covert channels in steganography. There are various methods that exist in other domains to detect hidden messages…

Machine Learning · Computer Science 2018-10-08 Ho Bae , Byunghan Lee , Sunyoung Kwon , Sungroh Yoon

Matrix multiplication is a foundational operation in scientific computing and machine learning, yet its computational complexity makes it a significant bottleneck for large-scale applications. The shift to parallel architectures, primarily…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-07-30 Mufakir Qamar Ansari , Mudabir Qamar Ansari

Graph neural networks (GNNs) are powerful tools for learning from graph data and are widely used in various applications such as social network recommendation, fraud detection, and graph search. The graphs in these applications are…

Machine Learning · Computer Science 2021-06-14 Jialin Dong , Da Zheng , Lin F. Yang , Geroge Karypis

This paper presents a probabilistic approach for DNA sequence analysis. A DNA sequence consists of an arrangement of the four nucleotides A, C, T and G and different representation schemes are presented according to a probability measure…

Quantitative Methods · Quantitative Biology 2010-02-12 Amrita Priyam , B. M. Karan , G. Sahoo

Recurrent neural networks (RNNs) are widely used to model sequential data but their non-linear dependencies between sequence elements prevent parallelizing training over sequence length. We show the training of RNNs with only linear…

Neural and Evolutionary Computing · Computer Science 2018-02-23 Eric Martin , Chris Cundy

Recently, Deep Neural Networks (DNNs) have recorded great success in handling medical and other complex classification tasks. However, as the sizes of a DNN model and the available dataset increase, the training process becomes more complex…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-02-08 Samson B. Akintoye , Liangxiu Han , Xin Zhang , Haoming Chen , Daoqiang Zhang