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We report experimental evidence of electrostatic inhibition of fast electrons, generated in a highly resistive material upon irradiation with an intense ultra-short ($10^{16} W/cm^{2}$, $100 fmsec$) laser pulse. The experiment involves…
We demonstrate control over attosecond pulse generation and shaping by numerically optimizing the synthesis of few-cycle to sub-cycle driver waveforms. The optical waveform synthesis takes place in an ultrabroad spectral band covering the…
DNA supercoiling plays an important role in a variety of cellular processes. The torsional stress related with supercoiling may be also involved in gene regulation through the local structure and dynamics of the double helix. To check this…
Evolution of the spatial arrangement of cells in a primary culture of cardiac tissue derived from newborn rats was studied experimentally over extended period. It was found that cells attract each other spontaneously to form a clustered…
Mode-locked lasers play the role of the ideal testbeds for studying self-coherent structures, dissipative solitons, with stable spatiotemporal profiles supported by the balance between dispersion and nonlinearity. However, under some…
Cells regulate gene expression in part by forming DNA-protein condensates in the nucleus. While existing theories describe the equilibrium size and stability of such condensates, their dynamics remain less understood. Here, we use…
We propose dynamical Bragg mirrors as a means to compress intense short optical pulses. We show that strong-field photoexcitation of carriers changes the refractive index of the layers and leads to motion of the resonance-defined boundary…
The sensitivity of the native states of protein-like heteropolymers to mutations modelled as perturbations in the interaction potential between amino acids is studied. The stability threshold against mutations is shown to be zero for random…
Engineering simple, artificial models of living cells allows synthetic biologists to study cellular functions under well-controlled conditions. Reconstituting multicellular behaviors with synthetic cell-mimics is still a challenge because…
Nonlinear evolutions of an ultra-intense, short laser pulse due to the wake excitation inside the plasma are studied by means of detailed Particle-In-Cell (PIC) simulations and comprehensive analyses. Pulse lengths both longer and shorter…
In this study we evaluate, at full atomic detail, the folding processes of two small helical proteins, the B domain of protein A and the Villin headpiece. Folding kinetics are studied by performing a large number of ab initio Monte Carlo…
A system consisting of the cubic complex Ginzburg-Landau equation which is linearly coupled to an additional linear dissipative equation, is considered. The model was introduced earlier in the context of dual-core nonlinear optical fibers…
Hematopoiesis is a complex biological process that leads to the production and regulation of blood cells. It is based upon differentiation of stem cells under the action of growth factors. A mathematical approach of this process is proposed…
In this work we demonstrate the generation of two intense, ultrafast laser pulses that allow a controlled interferometric measurement of higher harmonic generation pulses with 12.8 attoseconds in resolution (half the atomic unit of time)…
This work theoretically investigates high-order harmonic generation in rare gas atoms driven by two temporally delayed ultrashort laser pulses. Apart from their temporal delay, the two pulses are identical. Using a single-atom model of the…
When propagated action potentials in cardiac tissue interact with local heterogeneities, reflected waves can sometimes be induced. These reflected waves have been associated with the onset of cardiac arrhythmias, and while their generation…
We analyse a model of Hes1 gene transcription and protein synthesis with a negative feedback loop. The effect of multiple binding sites in the Hes1 promoter as well as the dimer formation process are taken into account. We consider three,…
We theoretically and experimentally demonstrate the generation of high-quality low duty-cycle pulse trains at repetition rates of 28 GHz, 56 GHz and 112 GHz. Starting from a continuous wave we benefit from phase modulations in the temporal…
Genetically encoded regulatory circuits control biological function. A major focus of systems biology is to understand these circuits by establishing the relationship between specific structures and functions. Of special interest are…
We demonstrate a remarkably effective single-stage compression technique for ultrafast pulses in the visible electromagnetic spectrum using second-harmonic pulses at 515 nmderived from a 1030 nm Yb-based femtosecond regenerative amplifier.…