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DNA looping participates in transcriptional regulation, for instance, by allowing distal binding sites to act synergistically. Here we study this process and compare different regulatory mechanisms based on repression with and without…
Transcription is regulated through interplay between transcription factors, an RNA polymerase(RNAP), and a promoter. Even for a simple repressive transcription factor that disturbs promoter activity at the initial binding of RNAP, its…
We show that polarons can sustain loop-like configurations in flexible bio-polymers and that the size of the loops depend on both the flexural rigidity of the polymer and the electron-phonon coupling constant. In particular we show that for…
Materials made from active, living, or robotic components can display emergent properties arising from local sensing and computation. Here, we realize a freestanding active metabeam with piezoelectric elements and electronic feed-forward…
We report generation of a femtosecond supercontinuum extending from the ultraviolet to the near-infrared and detection of its carrier-envelope phase variation by f-to-2f interferometry. The spectrum is generated in a gas-filled hollow-core…
An atomic protein model with a minimalistic potential is developed and then tested on an alpha-helix and a beta-hairpin, using exactly the same parameters for both peptides. We find that melting curves for these sequences to a good…
Our understanding of the elusive radio-pulsar emission mechanism would be deepened by determining the locality of the emission. Pulsars in which the two poles interact can potentially help solve this challenge. We here report the discovery…
The spectrum of a CW field whose phase experiences a periodic sawtooth modulation is analyzed. Two types of the sawtooth phase modulation are considered. One is created by combining many harmonics of the fundamental frequency. The second is…
One of the main problems of drug design is that of optimizing the drug--target interaction. In the case in which the target is a viral protein displaying a high mutation rate, a second problem arises, namely the eventual development of…
Electron holes (EH) are highly stable non-linear structures met omnipresently in driven collision-less hot plasmas. A mechanism destabilizing small perturbations into holes is essential for an often witnessed but less understood…
We demonstrate harmonic mode-locking in a semiconductor VCSEL using polarization-controlled delayed feedback. By integrating a rotatable $\lambda$/2-plate within an external cavity, we achieve precise control over pulse multiplicity and…
Loop formation in long molecules occurs many places in nature, from solutions of carbon nanotubes to polymers inside a cell. In this article, we review theoretical studies of the static and dynamic properties of polymer loops. For example,…
A programmable linear resistor with a compact footprint would have profound implications for microelectronics, enabling efficient in-sensor analog signal processing and in-memory computing. Non-volatile memory offers a potential solution…
We present a theoretical study of the photoelectron attosecond beating at the basis of RABBIT (Reconstruction of Attosecond Beating By Interference of Two-photon transitions) in the presence of autoionizing states. We show that, as a…
We present a detailed numerical study of ultrashort pulse compression using a three-stage hybrid all-bulk multipass cell scheme. By operating in the enhanced frequency chirp regime, we achieve the compression of pulses from around 180 fs to…
Almost all current approaches for engineering modular logic components in synthetic biology use first-order regulators, including most CRISPR/CAS, TAL, zinc finger, and RNA interference systems. Many practitioners understand intuitively…
Conventional kinesin is a homodimeric motor protein that is capable of walking unidirectionally along a cytoskeletal filament. While previous experiments indicated unyielding unidirectionality against an opposing load up to the so-called…
Coherent inter-conversion between an optical and a mechanical excitation in an optomechanical resonator can be used for the storage of an optical pulse as an excitation in a mechanical oscillator. This optomechanical light storage is…
Post-compression of ultra-short laser pulses via self-phase modulation is routinely employed for the generation of laser pulses with optical bandwidths reaching far beyond the laser gain limitations. While high compression factors can be…
The ability of genetic isolation to block gene flow plays a key role in the speciation of sexually reproducing organisms. This paper analyses the hybrid zone dynamics affected by "weak" Haldane's rule, namely the incomplete hybrids…