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While modern biotechnologies allow synthesizing new proteins and function measurements at scale, efficiently exploring a protein sequence space and engineering it remains a daunting task due to the vast sequence space of any given protein.…

Biomolecules · Quantitative Biology 2024-01-15 Jiahao Qiu , Hui Yuan , Jinghong Zhang , Wentao Chen , Huazheng Wang , Mengdi Wang

Over the last 10 to 15 years, active inference has helped to explain various brain mechanisms from habit formation to dopaminergic discharge and even modelling curiosity. However, the current implementations suffer from an exponential…

Artificial Intelligence · Computer Science 2022-04-13 Théophile Champion , Lancelot Da Costa , Howard Bowman , Marek Grześ

In games like chess, strategy evolves dramatically across distinct phases - the opening, middlegame, and endgame each demand different forms of reasoning and decision-making. Yet, many modern chess engines rely on a single neural network to…

Machine Learning · Computer Science 2025-06-18 Felix Helfenstein , Johannes Czech , Jannis Blüml , Max Eisel , Kristian Kersting

Reinforcement learning (RL) is emerging as a powerful paradigm for enabling large language models (LLMs) to perform complex reasoning tasks. Recent advances indicate that integrating RL with retrieval-augmented generation (RAG) allows LLMs…

Computation and Language · Computer Science 2025-08-13 Wentao Jiang , Xiang Feng , Zengmao Wang , Yong Luo , Pingbo Xu , Zhe Chen , Bo Du , Jing Zhang

Motion Planning is necessary for robots to complete different tasks. Rapidly-exploring Random Tree (RRT) and its variants have been widely used in robot motion planning due to their fast search in state space. However, they perform not well…

Robotics · Computer Science 2022-05-19 Zhirui Sun , Jiankun Wang , Max Q. -H. Meng

Optimal path planning requires finding a series of feasible states from the starting point to the goal to optimize objectives. Popular path planning algorithms, such as Effort Informed Trees (EIT*), employ effort heuristics to guide the…

Rapid advancements in deep learning have led to many recent breakthroughs. While deep learning models achieve superior performance, often statistically better than humans, their adoption into safety-critical settings, such as healthcare or…

Machine Learning · Computer Science 2022-04-08 Marko Vasic , Andrija Petrovic , Kaiyuan Wang , Mladen Nikolic , Rishabh Singh , Sarfraz Khurshid

With the aim of improving performance in Markov Decision Problem in an Off-Policy setting, we suggest taking inspiration from what is done in Offline Reinforcement Learning (RL). In Offline RL, it is a common practice during policy learning…

Artificial Intelligence · Computer Science 2024-10-29 Jérôme Arjonilla , Abdallah Saffidine , Tristan Cazenave

This paper introduces a new paradigm for minimax game-tree search algo- rithms. MT is a memory-enhanced version of Pearls Test procedure. By changing the way MT is called, a number of best-first game-tree search algorithms can be simply and…

Artificial Intelligence · Computer Science 2014-04-08 Aske Plaat , Jonathan Schaeffer , Wim Pijls , Arie de Bruin

In this paper, we consider the problem of building learning agents that can efficiently learn to navigate in constrained environments. The main goal is to design agents that can efficiently learn to understand and generalize to different…

Machine Learning · Computer Science 2020-03-04 Kei Ota , Yoko Sasaki , Devesh K. Jha , Yusuke Yoshiyasu , Asako Kanezaki

Tree-form sequential decision making (TFSDM) extends classical one-shot decision making by modeling tree-form interactions between an agent and a potentially adversarial environment. It captures the online decision-making problems that each…

Computer Science and Game Theory · Computer Science 2021-03-09 Gabriele Farina , Robin Schmucker , Tuomas Sandholm

Building an AI agent that can design on its own has been a goal since the 1980s. Recently, deep learning has shown the ability to learn from large-scale data, enabling significant advances in data-driven design. However, learning over prior…

Machine Learning · Computer Science 2022-11-29 Ayush Raina , Jonathan Cagan , Christopher McComb

A big challenge in branch and bound lies in identifying the optimal node within the search tree from which to proceed. Current state-of-the-art selectors utilize either hand-crafted ensembles that automatically switch between naive sub-node…

Machine Learning · Computer Science 2024-06-06 Alexander Mattick , Christopher Mutschler

While the recent advances in deep reinforcement learning have achieved impressive results in learning motor skills, many of the trained policies are only capable within a limited set of initial states. We propose a technique to break down a…

Robotics · Computer Science 2018-11-19 Visak C. V. Kumar , Sehoon Ha , C. Karen Liu

Deep research agents, which synthesize information across diverse sources, are significantly constrained by the sequential nature of reasoning. This bottleneck results in high latency, poor runtime adaptability, and inefficient resource…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-03-31 Lunyiu Nie , Nedim Lipka , Ryan A. Rossi , Swarat Chaudhuri

Reinforcement learning has shown much success in games such as chess, backgammon and Go. However, in most of these games, agents have full knowledge of the environment at all times. In this paper, we describe a deep learning model in which…

Machine Learning · Computer Science 2022-04-05 Laura Greige , Peter Chin

Building predictive models for tabular data presents fundamental challenges, notably in scaling consistently, i.e., more resources translating to better performance, and generalizing systematically beyond the training data distribution.…

Decision trees are widely adopted machine learning models due to their simplicity and explainability. However, as training data size grows, standard methods become increasingly slow, scaling polynomially with the number of training…

Quantum Physics · Physics 2025-01-23 Niraj Kumar , Romina Yalovetzky , Changhao Li , Pierre Minssen , Marco Pistoia

Traditional reinforcement learning and planning typically requires vast amounts of data and training to develop effective policies. In contrast, large language models (LLMs) exhibit strong generalization and zero-shot capabilities, but…

Artificial Intelligence · Computer Science 2025-07-30 Jonathan Light , Min Cai , Weiqin Chen , Guanzhi Wang , Xiusi Chen , Wei Cheng , Yisong Yue , Ziniu Hu

In reinforcement learning, agents often learn policies for specific tasks without the ability to generalize this knowledge to related tasks. This paper introduces an algorithm that attempts to address this limitation by decomposing neural…

Machine Learning · Computer Science 2024-10-16 Mahdi Alikhasi , Levi H. S. Lelis