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We study the electro-diffusion properties of a domain containing a cusp-shaped structure in three dimensions when one ionic specie is dominant. The mathematical problem consists in solving the steady-state Poisson-Nernst-Planck (PNP)…

Neurons and Cognition · Quantitative Biology 2017-10-09 J. Cartailler , D. Holcman

In studies of the brain and the nervous system, extracellular signals - as measured by local field potentials (LFPs) or electroencephalography (EEG) - are of capital importance, as they allow to simultaneously obtain data from multiple…

Neurons and Cognition · Quantitative Biology 2019-06-10 Jurgis Pods

The flow of ions through permeable channels causes voltage drop in physiological nanodomains such as synapses, dendrites and dendritic spines, and other protrusions. How the voltage changes around channels in these nanodomains has remained…

Soft Condensed Matter · Physics 2025-01-10 Frédéric Paquin-Lefebvre , David Holcman

The Poisson Nernst-Planck equations for charge concentration and electric potential in a ball is a model of electro-diffusion of ions in the head of a neuronal dendritic spine. We study the relaxation and the steady state when an initial…

Classical Physics · Physics 2015-05-12 Z. Schuss J. Cartailler , D. Holcman

The Poisson-Nernst-Planck (PNP) diffusional model for the immittance or impedance spectroscopy response of an electrolytic cell in a finite-length situation is extended to a general framework. In this new formalism, the bulk behavior of the…

Characterizing the local voltage distribution within nanophysiological domains, driven by ionic currents through membrane channels, is crucial for studying cellular activity in modern biophysics, yet it presents significant experimental and…

Soft Condensed Matter · Physics 2026-05-14 Frédéric Paquin-Lefebvre , Alejandro Barea Moreno , David Holcman

The non-equilibrium steady states of a semi-infinite quasi-one-dimensional univalent binary electrolyte solution, characterised by non-vanishing electric currents, are investigated by means of Poisson-Nernst-Planck (PNP) theory. Exact…

Soft Condensed Matter · Physics 2024-01-09 Markus Bier

Voltage and charge distributions in cellular microdomains regulate communications, excitability, and signal transduction. We report here new electrical laws in a cell, which follow from a nonlinear electro-diffusion model. These newly…

Biological Physics · Physics 2017-01-03 Jerome Cartailler , Zeev Schuss , David Holcman

The distribution of voltage in sub-micron cellular domains remains poorly understood. In neurons, the voltage results from the difference in ionic concentrations which are continuously maintained by pumps and exchangers. However, it not…

Soft Condensed Matter · Physics 2020-03-26 Alexis Tricot , Igor M. Sokolov , David Holcman

This work is concerned with the stationary Poisson--Nernst--Planck equation with a large parameter which describes a huge number of ions occupying an electrolytic region. Firstly, we focus on the model with a single specie of positive…

Analysis of PDEs · Mathematics 2023-11-20 Jhih-Hong Lyu , Chiun-Chang Lee , Tai-Chia Lin

Effects of the adsorption-desorption process on the immittance response of an electrolytic cell are theoretically investigated in the framework of the diffusional Poisson-Nernst-Planck (PNP) continuum model, when the generation and…

The electron and current density distributions in the close proximity of quantum point contacts (QPCs) are investigated. A three dimensional Poisson equation is solved self-consistently to obtain the electron density and potential profile…

Mesoscale and Nanoscale Physics · Physics 2009-11-13 S. Arslan , E. Cicek , D. Eksi , S. Aktas , A. Weichselbaum , A. Siddiki

We demonstrate the role of selectivity variation in the structure of the non-equilibrium extended space-charge using 1D analytic and 2D numerical Poisson-Nernst-Planck models for the electro- diffusive transport of a symmetric electrolyte.…

Soft Condensed Matter · Physics 2015-03-25 Jarrod Schiffbauer , Neta Leibowitz , Gilad Yossifon

Ion flow in charged nanopores is strongly influenced by the ratio of the Debye length to the pore radius. We investigate the asymptotic behaviour of solutions to the Poisson-Nernst-Planck (PNP) system in narrow pore like geometries and…

Analysis of PDEs · Mathematics 2019-04-10 B. Matejczyk , J. -F. Pietschmann , G. Richardson , M. -T. Wolfram

The main goal of this work is to examine the qualitative effect of ion sizes via a steady-state boundary value problem. We study a one-dimensional version of a Poisson-Nernst-Planck system with a local hard-sphere potential model for ionic…

Mathematical Physics · Physics 2022-03-18 Weishi Liu , Hamid Mofidi

We investigate the effect of adsorption-desorption phenomenon of ions in an asymmetric electrolytic cell at open circuit conditions. Our approach is based on the Poisson-Nernst-Planck theory for electrolytes and the kinetic model of…

Chemical Physics · Physics 2017-12-06 S. Bousiadi , I. Lelidis

The steady state of ions diffusion in polymer electrolytes at arbitrary applied voltage is analyzed in the framework of the Nernst-Planck-Poisson equation (NPP). The exact solution of the set of equations is found without the assumption of…

Soft Condensed Matter · Physics 2008-06-10 Anatoly Golovnev , Steffen Trimper

Cellular electrophysiology is often modeled using the cable equations. The cable model can only be used when ionic concentration effects and three dimensional geometry effects are negligible. The Poisson model, in which the electrostatic…

Neurons and Cognition · Quantitative Biology 2009-01-27 Yoichiro Mori

We study the potential and the charge distribution across the interface of a plasma and a dielectric wall. For this purpose, the charge bound to the wall is modelled as a quasi-stationary electron surface layer which satisfies Poisson's…

Plasma Physics · Physics 2015-05-30 Rafael L. Heinisch , Franz X. Bronold , Holger Fehske

The extracellular space has an ambiguous role in neuroscience. It is present in every physiologically relevant system and often used as a measurement site in experimental recordings, but it has received subordinate attention compared to the…

Neurons and Cognition · Quantitative Biology 2017-05-02 Jurgis Pods
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