Related papers: Do ROS really slow down aging in C. elegans?
This paper suggests that aging is influenced synthetically by pro-aging factors such as ROS and anti-aging factors such as protective responses. The anti-aging effect may be side effects of retrograde responses motivated against adverse…
The question of why we age is a fundamental one. It is about who we are, and it also might have critical practical aspects as we try to find ways to age slower. Or to not age at all. Different reasons point at distinct strategies for the…
Age-related muscle decline, a condition referred to as sarcopenia and defined as loss in muscle mass and muscle strength over time, is one of the most pervasive problems of the elderly, such that significant declines in strength and…
Relative ageing describes how a system ages with respect to another one. The ageing faster orders are the ones which compare the relative ageings of two systems. Here, we study ageing faster orders in the hazard and the reversed hazard…
As the global population ages, there is increased interest in living longer and improving one's quality of life in later years. However, studying aging - the decline in body function - is expensive and time-consuming. And despite research…
My analysis uses methods developed for data mining microarray experiments, adapted for ageing research. Methods bridge knowledge of statistical mechanics with data mining methods developed in statistical mathematics. Analyses can reveal how…
The relaxation dynamics of many disordered systems, such as structural glasses, proteins, granular materials or spin glasses, is not completely frozen even at very low temperatures. This residual motion leads to a change of the properties…
Many theories have been proposed to answer two questions on aging: "Why do we age?" and "How do we age?" Among them, evolutionary theories are proposed to interpret the evolutionary advantage of aging, and "saving resources for group…
Slow relaxation occurs in many physical and biological systems. `Creep' is an example from everyday life: when stretching a rubber band, for example, the recovery to its equilibrium length is not, as one might think, exponential: the…
We present some simple computer simulations that indicate that at short time aging is realized in a simple model of binary glasses. It is interesting to note that modest computer simulations are enough to evidenziate this effect. We also…
Calcium and reactive oxygen species (ROS) interact with each other and play an important role in cell signaling networks. Based on the existing mathematical models, we develop an age-dependent feedback control model to simulate the…
Understanding why we age is a long-lived open problem in evolutionary biology. Aging is prejudicial to the individual and evolutionary forces should prevent it, but many species show signs of senescence as individuals age. Here, I will…
Cellular senescence is thought to play a major role in age-related diseases, which cause nearly 67% of all human deaths worldwide. Recent research in mice showed that exercising mice had higher levels of telomerase, an enzyme that helps…
Much progress has been achieved in the age-dating of old stellar systems, and even of individual stars in the field, in the more than sixty years since the evolution of low-mass stars was first correctly described. In this paper, I provide…
We study the linear response to an external perturbation of a renewal process, in an aging condition that, with no perturbation, would yield super-diffusion. We use the phenomenological approach to the linear response adopted in earlier…
Aging in a single crystal spin glass ($\mathrm{Cu}_{0.92}\mathrm{Mn}_{0.08}$) has been measured using ac susceptibility techniques over a temperature range of $0.3 - 0.8 \, T_g$. In these studies, traditional aging experiments (or…
The accumulation of somatic mutations is a driver of cancer and has long been associated with ageing. Due to limitations in quantifying mutation burden with age in non-cancerous tissues, the impact of somatic mutations in other ageing…
Aging is thought to be a consequence of intrinsic breakdowns in how genetic information is processed. But mounting experimental evidence suggests that aging can be slowed. To help resolve this mystery, I derive a mortality equation which…
Complex systems having metastable elements often demonstrate nearly log-time relaxations and a kind of aging: repeated stimuli weaken the system's relaxational response. Granular matter is known to exhibit a wealth of such behaviors, for…
The relative ageing is an important notion which is useful to measure how a system ages relative to another one. Among all existing stochastic orders, there are two important orders describing the relative ageing of two systems, namely,…