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Biologically-informed neural networks (BINNs), an extension of physics-informed neural networks [1], are introduced and used to discover the underlying dynamics of biological systems from sparse experimental data. In the present work, BINNs…

Quantitative Methods · Quantitative Biology 2021-01-27 John H. Lagergren , John T. Nardini , Ruth E. Baker , Matthew J. Simpson , Kevin B. Flores

As proteins with similar structures often have similar functions, analysis of protein structures can help predict protein functions and is thus important. We consider the problem of protein structure classification, which computationally…

Machine Learning · Statistics 2019-10-08 Hongyu Guo , Khalique Newaz , Scott Emrich , Tijana Milenkovic , Jun Li

Recent approaches based on metric learning have achieved great progress in few-shot learning. However, most of them are limited to image-level representation manners, which fail to properly deal with the intra-class variations and spatial…

Computer Vision and Pattern Recognition · Computer Science 2021-11-02 Chao Dong , Qi Ye , Wenchao Meng , Kaixiang Yang

Deep sequencing has become one of the most popular tools for transcriptome profiling in biomedical studies. While an abundance of computational methods exists for "normalizing" sequencing data to remove unwanted between-sample variations…

Genomics · Quantitative Biology 2022-01-14 Yannick Düren , Johannes Lederer , Li-Xuan Qin

In this work we set out to find a method to classify protein structures using a Deep Learning methodology. Our Artificial Intelligence has been trained to recognize complex biomolecule structures extrapolated from the Protein Data Bank…

Machine Learning · Computer Science 2021-11-04 Damiano Perri , Marco Simonetti , Andrea Lombardi , Noelia Faginas-Lago , Osvaldo Gervasi

MicroRNAs (miRNAs) are small non-coding RNAs that function as regulators of gene expression. In recent years, there has been a tremendous and growing interest among researchers to investigate the role of miRNAs in normal cellular as well as…

Applications · Statistics 2018-04-13 Noirrit Kiran Chandra , Richa Singh , Sourabh Bhattacharya

This work proposes a novel approach to the deep hierarchical classification task, i.e., the problem of classifying data according to multiple labels organized in a rigid parent-child structure. It consists in a multi-output deep neural…

Artificial Intelligence · Computer Science 2024-10-07 Lorenzo Fiaschi , Marco Cococcioni

In differentially private (DP) tabular data synthesis, the consensus is that statistical models are better than neural network (NN)-based methods. However, we argue that this conclusion is incomplete and overlooks the challenge of densely…

Machine Learning · Computer Science 2025-11-19 Kai Chen , Chen Gong , Tianhao Wang

miRNA and gene expression profiles have been proved useful for classifying cancer samples. Efficient classifiers have been recently sought and developed. A number of attempts to classify cancer samples using miRNA/gene expression profiles…

Computational Engineering, Finance, and Science · Computer Science 2014-01-21 Rania Ibrahim , Noha A. Yousri , Mohamed A. Ismail , Nagwa M. El-Makky

Deep predictive coding networks are neuroscience-inspired unsupervised learning models that learn to predict future sensory states. We build upon the PredNet implementation by Lotter, Kreiman, and Cox (2016) to investigate if predictive…

Neurons and Cognition · Quantitative Biology 2019-07-02 Marcio Fonseca

Recently, microRNAs (miRNAs) have emerged as central posttranscriptional regulators of gene expression. miRNAs regulate many key biological processes, including cell growth, death, development and differentiation. This discovery is…

Molecular Networks · Quantitative Biology 2007-12-24 Edwin Wang

Long non-coding RNAs (lncRNAs) serve as crucial regulators in numerous biological processes. Although they share sequence similarities with messenger RNAs (mRNAs), lncRNAs perform entirely different roles, providing new avenues for…

Genomics · Quantitative Biology 2024-11-14 Nicholas Jeon , Xiaoning Qian , Lamin SaidyKhan , Paul de Figueiredo , Byung-Jun Yoon

Micro expression recognition (MER) is a very challenging area of research due to its intrinsic nature and fine-grained changes. In the literature, the problem of MER has been solved through handcrafted/descriptor-based techniques. However,…

Computer Vision and Pattern Recognition · Computer Science 2022-10-12 Monu Verma , Santosh Kumar Vipparthi , Girdhari Singh

Small interfering RNA (siRNA) is a short double-stranded RNA molecule (about 21-23 nucleotides) with the potential to cure diseases by silencing the function of target genes. Due to its well-understood mechanism, many siRNA-based drugs have…

Genomics · Quantitative Biology 2025-09-22 Honggen Zhang , Xiangrui Gao , Lipeng Lai

In the field of pattern recognition research, the method of using deep neural networks based on improved computing hardware recently attracted attention because of their superior accuracy compared to conventional methods. Deep neural…

Computer Vision and Pattern Recognition · Computer Science 2018-09-27 Kyongsik Yun , Alexander Huyen , Thomas Lu

Deep learning algorithms offer a powerful means to automatically analyze the content of medical images. However, many biological samples of interest are primarily transparent to visible light and contain features that are difficult to…

Computer Vision and Pattern Recognition · Computer Science 2017-09-22 Roarke Horstmeyer , Richard Y. Chen , Barbara Kappes , Benjamin Judkewitz

A Deep Neural Network (DNN) based algorithm is proposed for the detection and classification of faults in industrial plants. The proposed algorithm has the ability to classify faults, especially incipient faults that are difficult to detect…

Machine Learning · Computer Science 2022-12-02 Piyush Agarwal , Jorge Ivan Mireles Gonzalez , Ali Elkamel , Hector Budman

Leveraging artificial intelligence (AI)-driven electronic design and automation (EDA) tools, high-performance computing, and parallelized algorithms are essential for next-generation microprocessor innovation, ensuring continued progress in…

Hardware Architecture · Computer Science 2025-07-21 Riadul Islam , Dhandeep Challagundla

In this paper, we present a statistical-mechanical analysis of deep learning. We elucidate some of the essential components of deep learning---pre-training by unsupervised learning and fine tuning by supervised learning. We formulate the…

Machine Learning · Statistics 2015-06-23 Masayuki Ohzeki

This is a tutorial and survey paper on Boltzmann Machine (BM), Restricted Boltzmann Machine (RBM), and Deep Belief Network (DBN). We start with the required background on probabilistic graphical models, Markov random field, Gibbs sampling,…

Machine Learning · Computer Science 2022-08-09 Benyamin Ghojogh , Ali Ghodsi , Fakhri Karray , Mark Crowley