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Brain function emerges from coordinated activity across anatomically connected regions, where structural connectivity (SC) -- the network of white matter pathways - provides the physical substrate for functional connectivity (FC) -- the…

Neurons and Cognition · Quantitative Biology 2025-07-09 Sam Frank Kelemen , Joaquín Gõni , Sérgio Pequito , Arian Ashourvan

Identifying cortical regions critical for speech is essential for safe brain surgery in or near language areas. While Electrical Stimulation Mapping (ESM) remains the clinical gold standard, it is invasive and time-consuming. To address…

Data produced by resting-state functional Magnetic Resonance Imaging are widely used to infer brain functional connectivity networks. Such networks correlate neural signals to connect brain regions, which consist in groups of dependent…

Methodology · Statistics 2023-12-05 Hanâ Lbath , Alexander Petersen , Sophie Achard

The extraction of brain functioning features is a crucial step in the definition of brain-computer interfaces (BCIs). In the last decade, functional connectivity (FC) estimators have been increasingly explored based on their ability to…

Neurons and Cognition · Quantitative Biology 2019-12-06 Tiziana Cattai , Stefania Colonnese , Marie-Constance Corsi , Danielle S. Bassett , Gaetano Scarano , Fabrizio De Vico Fallani

Since gyri and sulci, two basic anatomical building blocks of cortical folding patterns, were suggested to bear different functional roles, a precise mapping from brain function to gyro-sulcal patterns can provide profound insights into…

Neurons and Cognition · Quantitative Biology 2022-05-24 Li Yang , Zhibin He , Changhe Li , Junwei Han , Dajiang Zhu , Tianming Liu , Tuo Zhang

Modeling the behavior of coupled networks is challenging due to their intricate dynamics. For example in neuroscience, it is of critical importance to understand the relationship between the functional neural processes and anatomical…

Machine Learning · Computer Science 2021-04-20 Hongyuan You , Sikun Lin , Ambuj K. Singh

Purpose: Arterial Spin Labeling (ASL) is a quantitative, non-invasive alternative to perfusion imaging with contrast agents. Fixing values of certain model parameters in traditional ASL, which actually vary from region to region, may…

Image and Video Processing · Electrical Eng. & Systems 2019-05-17 Anish Lahiri , Jeffrey A Fessler , Luis Hernandez-Garcia

We study the topological properties of functional connectivity patterns among cortical areas in the frequency domain. The cortical networks were estimated from high-resolution EEG recordings in a group of spinal cord injured patients and in…

Quantitative Methods · Quantitative Biology 2015-05-13 Roberta Sinatra , Fabrizio De Vico Fallani , Laura Astolfi , Fabio Babiloni , Febo Cincotti , Vito Latora , Donatella Mattia

In functional MRI (fMRI), effective connectivity analysis aims at inferring the causal influences that brain regions exert on one another. A common method for this type of analysis is structural equation modeling (SEM). We here propose a…

Quantitative Methods · Quantitative Biology 2024-09-10 G. Marrelec , A. Giron

Functional Magnetic Resonance Imaging (fMRI) has transformed our understanding of brain function in-vivo. However, the neurovascular coupling mechanisms underlying fMRI are somewhat "distant" from neural activity. Interestingly, evidence…

Medical Physics · Physics 2020-01-29 Daniel Nunes , Rita Gil , Noam Shemesh

We consider exploratory methods for the discovery of cortical functional connectivity. Typically, data for the i-th subject (i=1...NS) is represented as an NVxNT matrix Xi, corresponding to brain activity sampled at NT moments in time from…

Methodology · Statistics 2011-03-17 Roberto D. Pascual-Marqui , Rolando J. Biscay-Lirio

Many analyses of functional magnetic resonance imaging (fMRI) examine functional connectivity (FC), or the statistical dependencies among distant brain regions. These analyses are typically exploratory, guiding future confirmatory research.…

Applications · Statistics 2025-10-20 Kyle Stanley , Nicole Lazar , Matthew Reimherr

This study investigated the dynamic connectivity patterns between EEG and fMRI modalities, contributing to our understanding of brain network interactions. By employing a comprehensive approach that integrated static and dynamic analyses of…

Machine Learning · Computer Science 2024-12-02 Guiran Liu , Binrong Zhu

Brain network analysis is a useful approach to studying human brain disorders because it can distinguish patients from healthy people by detecting abnormal connections. Due to the complementary information from multiple modal neuroimages,…

Image and Video Processing · Electrical Eng. & Systems 2023-08-22 Qiankun Zuo , Yanfei Zhu , Libin Lu , Zhi Yang , Yuhui Li , Ning Zhang

Arterial spin labeling perfusion MRI is a noninvasive technique for measuring quantitative cerebral blood flow (CBF), but the measurement is subject to a low signal-to-noise-ratio(SNR). Various post-processing methods have been proposed to…

Computer Vision and Pattern Recognition · Computer Science 2018-01-31 Danfeng Xie , Li Bai , Ze Wang

Functional connectomes capture brain interactions via synchronized fluctuations in the functional magnetic resonance imaging signal. If measured during rest, they map the intrinsic functional architecture of the brain. With task-driven…

Neurons and Cognition · Quantitative Biology 2013-04-16 Gaël Varoquaux , R. C. Craddock

Learning-based methods have recently enabled performance leaps in analysis of high-dimensional functional MRI (fMRI) time series. Deep learning models that receive as input functional connectivity (FC) features among brain regions have been…

Signal Processing · Electrical Eng. & Systems 2023-01-03 Irmak Sivgin , Hasan A. Bedel , Şaban Öztürk , Tolga Çukur

Effective connectivity analysis in functional magnetic resonance imaging (fMRI) studies directional interactions among brain regions and experimental stimuli. Dynamic causal modeling (DCM) is a widely used method to estimate effective…

Methodology · Statistics 2026-05-15 Kaitlyn R. Fales , Hyebin Song , Nicole A. Lazar

Sleep disorder is a serious global public health issue, with cognitive-emotional dysfunction being a core symptom. The analysis of multimodal MRI data provides an effective method for detecting sleep deprivation-induced neural network…

Neurons and Cognition · Quantitative Biology 2025-12-02 Mengyuan Liu , Jing Hu , Zhenzhen Ru , Ruomeng Quan , Xu Zhang , Ning Qiang , Jin Li

The brain is often studied from a network perspective, where functional activity is assessed using functional Magnetic Resonance Imaging (fMRI) to estimate connectivity between predefined neuronal regions. Functional connectivity can be…

Applications · Statistics 2025-07-22 Olivier Bisson , Yanis Aeschlimann , Samuel Deslauriers-Gauthier , Xavier Pennec
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