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Mental health problems impact quality of life of millions of people around the world. However, diagnosis of mental health disorders is a challenging problem that often relies on self-reporting by patients about their behavioral patterns.…

Machine Learning · Computer Science 2021-02-23 Shayan Hassantabar , Joe Zhang , Hongxu Yin , Niraj K. Jha

High-resolution connectomics data allows for the identification of dysfunctional mitochondria which are linked to a variety of diseases such as autism or bipolar. However, manual analysis is not feasible since datasets can be petabytes in…

Computer Vision and Pattern Recognition · Computer Science 2020-06-22 Vincent Casser , Kai Kang , Hanspeter Pfister , Daniel Haehn

Background: This study investigates how variations in Major Depressive Disorder (MDD) symptoms, quantified by the Hamilton Rating Scale for Depression (HAM-D), causally influence the prescription of SSRIs versus SNRIs. Methods: We applied…

Artificial Intelligence · Computer Science 2025-08-26 Xinyu Qin , Mark H. Chignell , Alexandria Greifenberger , Sachinthya Lokuge , Elssa Toumeh , Tia Sternat , Martin Katzman , Lu Wang

Perinatal depression (PND) affects 1 in 5 mothers, with 85% lacking support. Digital health tools offer early identification and prevention, potentially reducing PND risk by over 50% and improving engagement. Despite high interest, user…

Quantitative Methods · Quantitative Biology 2025-05-13 Rachel L. Wiley , Jim Schwoebel , Joel Shor , Bindu Chanagala , Matias Caccia , Adolfo M. García , Sheehan D. Fisher , Martin G. Frasch

Large Language Models (LLMs) have demonstrated remarkable success across diverse fields, establishing a powerful paradigm for complex information processing. This has inspired the integration of speech into LLM frameworks, often by…

Audio and Speech Processing · Electrical Eng. & Systems 2025-12-30 Xiangyu Zhang , Fuming Fang , Peng Gao , Bin Qin , Beena Ahmed , Julien Epps

Alzheimer's disease (AD) is the most prevalent form of dementia. Traditional methods cannot achieve efficient and accurate diagnosis of AD. In this paper, we introduce a novel method based on dynamic functional connectivity (dFC) that can…

Computer Vision and Pattern Recognition · Computer Science 2020-06-25 Xingwei An , Yutao Zhou , Yang Di , Dong Ming

Multimodal depression classification has gained immense popularity over the recent years. We develop a multimodal depression classification system using articulatory coordination features extracted from vocal tract variables and text…

Audio and Speech Processing · Electrical Eng. & Systems 2022-02-15 Nadee Seneviratne , Carol Espy-Wilson

Depression is a highly prevalent and disabling condition that incurs substantial personal and societal costs. Current depression diagnosis involves determining the depression severity of a person through self-reported questionnaires or…

Computation and Language · Computer Science 2025-03-27 Aishik Mandal , Dana Atzil-Slonim , Thamar Solorio , Iryna Gurevych

In universal environment, a patient-friendly inexpensive method is needed to realize the early diagnosis of depression, which is believed to be an effective way to reduce the mortality of depression. The purpose of this study is only to…

Signal Processing · Electrical Eng. & Systems 2020-02-28 Qiuxia Shi , Ang Liu , Rongyan Chen , Jian Shen , Qinglin Zhao , Bin Hu

With more than 300 million people depressed worldwide, depression is a global problem. Due to access barriers such as social stigma, cost, and treatment availability, 60% of mentally-ill adults do not receive any mental health services.…

Computer Vision and Pattern Recognition · Computer Science 2018-11-28 Albert Haque , Michelle Guo , Adam S Miner , Li Fei-Fei

Parkinson's disease (PD) is a common and complex neurodegenerative disorder with 5 stages in the Hoehn and Yahr scaling. Given the heterogeneity of PD, it is challenging to classify early stages 1 and 2 and detect brain function…

Neurons and Cognition · Quantitative Biology 2022-07-22 Xueqi Guo , Sule Tinaz , Nicha C. Dvornek

Major Depressive Disorder (MDD) is a highly prevalent mental health condition, and a deeper understanding of its neurocognitive foundations is essential for identifying how core functions such as emotional and self-referential processing…

Depression has been the leading cause of mental-health illness worldwide. Major depressive disorder (MDD), is a common mental health disorder that affects both psychologically as well as physically which could lead to loss of lives. Due to…

Computer Vision and Pattern Recognition · Computer Science 2019-09-05 Anupama Ray , Siddharth Kumar , Rutvik Reddy , Prerana Mukherjee , Ritu Garg

Early detection of depression from social media data offers a valuable opportunity for timely intervention. However, this task poses significant challenges, requiring both professional medical knowledge and the development of accurate and…

Computation and Language · Computer Science 2025-03-20 Xiangyong Chen , Xiaochuan Lin

The available evidence suggests that dynamic functional connectivity (dFC) can capture time-varying abnormalities in brain activity in resting-state cerebral functional magnetic resonance imaging (rs-fMRI) data and has a natural advantage…

Neurons and Cognition · Quantitative Biology 2023-09-13 Cheng Zhu , Ying Tan , Shuqi Yang , Jiaqing Miao , Jiayi Zhu , Huan Huang , Dezhong Yao , Cheng Luo

Reliable diagnosis of depressive disorder is essential for both optimal treatment and prevention of fatal outcomes. In this study, we aimed to elucidate the effectiveness of two non-linear measures, Higuchi Fractal Dimension (HFD) and…

Introduction: Identifying neurobiological differences between patients suffering from Major Depressive Disorder (MDD) and healthy individuals has been a mainstay of clinical neuroscience for decades. However, recent meta- and mega-analyses…

This study investigates the potential of multimodal data integration, which combines electroencephalogram (EEG) data with sociodemographic characteristics like age, sex, education, and intelligence quotient (IQ), to diagnose mental diseases…

Machine Learning · Computer Science 2025-02-07 Himanshi Singh , Sadhana Tiwari , Sonali Agarwal , Ritesh Chandra , Sanjay Kumar Sonbhadra , Vrijendra Singh

This study integrates causal inference, graph analysis, temporal complexity measures, and machine learning to examine whether individual symptom trajectories can reveal meaningful diagnostic patterns. Testing on a longitudinal dataset of…

Applications · Statistics 2025-07-22 Eleonora Vitanza , Pietro DeLellis , Chiara Mocenni , Manuel Ruiz Marin

Depression is a common mental health disorder that can cause consequential symptoms with continuously depressed mood that leads to emotional distress. One category of depression is Concealed Depression, where patients intentionally or…

Computer Vision and Pattern Recognition · Computer Science 2023-08-01 Xiaohui Chen , Tie Luo
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