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Major depressive disorder (MDD) impacts more than 300 million people worldwide, highlighting a significant public health issue. However, the uneven distribution of medical resources and the complexity of diagnostic methods have resulted in…

Computation and Language · Computer Science 2025-05-02 Yuyang Sha , Hongxin Pan , Wei Xu , Weiyu Meng , Gang Luo , Xinyu Du , Xiaobing Zhai , Henry H. Y. Tong , Caijuan Shi , Kefeng Li

We describe the development of a model to detect user-level clinical depression based on a user's temporal social media posts. Our model uses a Depression Symptoms Detection (DSD) classifier, which is trained on the largest existing samples…

Computation and Language · Computer Science 2023-03-31 Nawshad Farruque , Randy Goebel , Sudhakar Sivapalan , Osmar R. Zaïane

Sleep disorder is a serious global public health issue, with cognitive-emotional dysfunction being a core symptom. The analysis of multimodal MRI data provides an effective method for detecting sleep deprivation-induced neural network…

Neurons and Cognition · Quantitative Biology 2025-12-02 Mengyuan Liu , Jing Hu , Zhenzhen Ru , Ruomeng Quan , Xu Zhang , Ning Qiang , Jin Li

Depression manifests through a diverse set of symptoms such as sleep disturbance, loss of interest, and concentration difficulties. However, most existing works treat depression prediction either as a binary label or an overall severity…

Computation and Language · Computer Science 2026-02-18 Chaithra Nerella , Chiranjeevi Yarra

Brain functional connectivity (FC) reveals biomarkers for identification of various neuropsychiatric disorders. Recent application of deep neural networks (DNNs) to connectome-based classification mostly relies on traditional convolutional…

Neurons and Cognition · Quantitative Biology 2024-01-31 Fuad Noman , Chee-Ming Ting , Hakmook Kang , Raphael C. -W. Phan , Brian D. Boyd , Warren D. Taylor , Hernando Ombao

Depression is a leading cause of death worldwide, and the diagnosis of depression is nontrivial. Multimodal learning is a popular solution for automatic diagnosis of depression, and the existing works suffer two main drawbacks: 1) the…

Multimedia · Computer Science 2023-01-03 Chengbo Yuan , Qianhui Xu , Yong Luo

Schizophrenia (SZ) is a brain disorder leading to detached mind's normally integrated processes. Hence, the exploration of the symptoms in relation to functional connectivity (FC) had great relevance in the field. FC can be investigated on…

Neurons and Cognition · Quantitative Biology 2026-04-08 Davide Coluzzi , Giuseppe Baselli

Large, open-source consortium datasets have spurred the development of new and increasingly powerful machine learning approaches in brain connectomics. However, one key question remains: are we capturing biologically relevant and…

Alzheimer's disease (AD) is the only major cause of mortality in the world without an effective disease modifying treatment. Evidence supporting the so called disconnection hypothesis suggests that functional connectivity biomarkers may…

Brain disorders are an umbrella term for a group of neurological and psychiatric conditions that have a major effect on thinking, feeling, and acting. These conditions encompass a wide range of conditions. The illnesses in question pose…

Neurons and Cognition · Quantitative Biology 2025-11-11 Aniruddha Saha , Soujanya Hazra , Sanjay Ghosh

As a critical mental health disorder, depression has severe effects on both human physical and mental well-being. Recent developments in EEG-based depression analysis have shown promise in improving depression detection accuracies. However,…

Machine Learning · Computer Science 2025-11-18 Zhijian Gong , Wenjia Dong , Xueyuan Xu , Fulin Wei , Chunyu Liu , Li Zhuo

Major depressive disorder (MDD) is one of the most common mental disorders, with significant impacts on many daily activities and quality of life. It stands as one of the most common mental disorders globally and ranks as the second leading…

Computer Vision and Pattern Recognition · Computer Science 2024-12-31 Nojod M. Alotaibi , Areej M. Alhothali , Manar S. Ali

Major depressive disorder (MDD) is a heterogeneous condition; multiple underlying neurobiological substrates could be associated with treatment response variability. Understanding the sources of this variability and predicting outcomes has…

We exploit altered patterns in brain functional connectivity as features for automatic discriminative analysis of neuropsychiatric patients. Deep learning methods have been introduced to functional network classification only very recently…

Machine Learning · Computer Science 2020-04-27 Chun-Ren Phang , Chee-Ming Ting , Fuad Noman , Hernando Ombao

Since anatomic MRI is presently not able to directly discern neuronal loss in Parkinson's Disease (PD), studying the associated functional connectivity (FC) changes seems a promising approach toward developing non-invasive and…

Neurons and Cognition · Quantitative Biology 2018-02-07 Liviu Badea , Mihaela Onu , Tao Wu , Adina Roceanu , Ovidiu Bajenaru

In neuroimaging analysis, fMRI can well assess the function changes for brain diseases with no obvious structural lesions. To date, most deep-learning-based fMRI studies have employed functional connectivity (FC) as the basic feature for…

Image and Video Processing · Electrical Eng. & Systems 2023-03-03 Wei Dai , Ziyao Zhang , Lixia Tian , Shengyuan Yu , Shuhui Wang , Zhao Dong , Hairong Zheng

Mental disorders including depression, anxiety, and other neurological disorders pose a significant global challenge, particularly among individuals exhibiting social avoidance tendencies. This study proposes a hybrid approach by leveraging…

Artificial Intelligence · Computer Science 2025-05-30 Mohammad Helal Uddin , Sabur Baidya

This study aimed to enhance disease classification accuracy from retinal fundus images by integrating fine-grained image features and global textual context using a novel multimodal deep learning architecture. Existing multimodal large…

Computer Vision and Pattern Recognition · Computer Science 2025-09-29 Jason Jordan , Mohammadreza Akbari Lor , Peter Koulen , Mei-Ling Shyu , Shu-Ching Chen

This paper presents our solution to the Multimodal Personality-aware Depression Detection (MPDD) challenge at ACM MM 2025. We propose a multimodal depression detection model in the Elderly that incorporates personality characteristics. We…

Sound · Computer Science 2025-10-10 Honghong Wang , Jing Deng , Rong Zheng

Neural biomarkers that can classify or predict disease are of broad interest to the neurological and psychiatric communities. Such biomarkers can be informative of disease state or treatment efficacy, even before there are changes in…

Neurons and Cognition · Quantitative Biology 2024-10-10 Xiaoxiao Sun , Chongkun Zhao , Sharath Koorathota , Paul Sajda