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In this paper, we introduced a novel feature extraction approach, named exclusive autoencoder (XAE), which is a supervised version of autoencoder (AE), able to largely improve the performance of nucleus detection and classification on…

Computer Vision and Pattern Recognition · Computer Science 2018-11-29 Chao-Hui Huang , Daniel Racoceanu

This study explores the application of supervised and unsupervised autoencoders (AEs) to automate nuclei classification in clear cell renal cell carcinoma (ccRCC) images, a diagnostic task traditionally reliant on subjective visual grading…

Image and Video Processing · Electrical Eng. & Systems 2025-04-07 Fatemeh Javadian , Zahra Aminparast , Johannes Stegmaier , Abin Jose

Information about the structure and composition of biopsy specimens can assist in disease monitoring and diagnosis. In principle, this can be acquired from Raman and infrared (IR) hyperspectral images (HSIs) that encode information about…

Medical Physics · Physics 2022-09-12 Ciaran Bench , Jayakrupakar Nallala , Chun-Chin Wang , Hannah Sheridan , Nicholas Stone

Unsupervised learning can leverage large-scale data sources without the need for annotations. In this context, deep learning-based autoencoders have shown great potential in detecting anomalies in medical images. However, especially…

Image and Video Processing · Electrical Eng. & Systems 2020-01-03 David Zimmerer , Simon Kohl , Jens Petersen , Fabian Isensee , Klaus Maier-Hein

Deep neural networks are powerful tools for biomedical image segmentation. These models are often trained with heavy supervision, relying on pairs of images and corresponding voxel-level labels. However, obtaining segmentations of…

Image and Video Processing · Electrical Eng. & Systems 2020-04-30 Evan M. Yu , Juan Eugenio Iglesias , Adrian V. Dalca , Mert R. Sabuncu

With the increasing use of high-precision system analysis programs in nuclear engineering, the number of high-fidelity computational data for accident simulation is exploding. Therefore, an algorithm that can achieve both automatic…

Signal Processing · Electrical Eng. & Systems 2022-08-30 Chengyuan Li , Meifu Li , Zhifang Qiu

Object-centric representations form the basis of human perception, and enable us to reason about the world and to systematically generalize to new settings. Currently, most works on unsupervised object discovery focus on slot-based…

Machine Learning · Computer Science 2022-11-21 Sindy Löwe , Phillip Lippe , Maja Rudolph , Max Welling

Self-supervised pretraining attempts to enhance model performance by obtaining effective features from unlabeled data, and has demonstrated its effectiveness in the field of histopathology images. Despite its success, few works concentrate…

Computer Vision and Pattern Recognition · Computer Science 2023-09-22 Zhiyun Song , Penghui Du , Junpeng Yan , Kailu Li , Jianzhong Shou , Maode Lai , Yubo Fan , Yan Xu

Pathology plays an important role in disease diagnosis, treatment decision-making and drug development. Previous works on interpretability for machine learning models on pathology images have revolved around methods such as attention value…

Sparse autoencoders (SAEs) emerged as a promising tool for mechanistic interpretability of transformer-based foundation models. Very recently, SAEs were also adopted for the visual domain, enabling the discovery of visual concepts and their…

Computer Vision and Pattern Recognition · Computer Science 2025-07-17 Muhammed Furkan Dasdelen , Hyesu Lim , Michele Buck , Katharina S. Götze , Carsten Marr , Steffen Schneider

Sparse autoencoders (SAEs) have been applied to large language models and protein language models, but not systematically to electronic health record (EHR) foundation models. We train TopK SAEs on FlatASCEND, a 14.5-million-parameter…

Machine Learning · Computer Science 2026-05-07 Chris Sainsbury , Feng Dong , Andreas Karwath

Sparse Autoencoders (SAEs) can efficiently identify candidate monosemantic features from pretrained neural networks for galaxy morphology. We demonstrate this on Euclid Q1 images using both supervised (Zoobot) and new self-supervised (MAE)…

Instrumentation and Methods for Astrophysics · Physics 2025-11-13 John F. Wu , Michael Walmsley

Part-level features are crucial for image understanding, but few studies focus on them because of the lack of fine-grained labels. Although unsupervised part discovery can eliminate the reliance on labels, most of them cannot maintain…

Computer Vision and Pattern Recognition · Computer Science 2025-07-17 Jiahao Xia , Yike Wu , Wenjian Huang , Jianguo Zhang , Jian Zhang

Segmentation and accurate localization of nuclei in histopathological images is a very challenging problem, with most existing approaches adopting a supervised strategy. These methods usually rely on manual annotations that require a lot of…

Image and Video Processing · Electrical Eng. & Systems 2020-07-17 Mihir Sahasrabudhe , Stergios Christodoulidis , Roberto Salgado , Stefan Michiels , Sherene Loi , Fabrice André , Nikos Paragios , Maria Vakalopoulou

Unsupervised learning can leverage large-scale data sources without the need for annotations. In this context, deep learning-based auto encoders have shown great potential in detecting anomalies in medical images. However, state-of-the-art…

Machine Learning · Computer Science 2018-12-17 David Zimmerer , Simon A. A. Kohl , Jens Petersen , Fabian Isensee , Klaus H. Maier-Hein

Image compression has been investigated as a fundamental research topic for many decades. Recently, deep learning has achieved great success in many computer vision tasks, and is gradually being used in image compression. In this paper, we…

Computer Vision and Pattern Recognition · Computer Science 2018-04-26 Zhengxue Cheng , Heming Sun , Masaru Takeuchi , Jiro Katto

Recent work on sparse autoencoders (SAEs) has shown promise in extracting interpretable features from neural networks and addressing challenges with polysemantic neurons caused by superposition. In this paper, we apply SAEs to the early…

Machine Learning · Computer Science 2024-09-10 Liv Gorton

Scientific archives now contain hundreds of petabytes of data across genomics, ecology, climate, and molecular biology that could reveal undiscovered patterns if systematically analyzed at scale. Large-scale, weakly-supervised datasets in…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Samuel Stevens , Jacob Beattie , Tanya Berger-Wolf , Yu Su

According to GLOBOCAN 2020, prostate cancer is the second most common cancer in men worldwide and the fourth most prevalent cancer overall. For pathologists, grading prostate cancer is challenging, especially when discriminating between…

Image and Video Processing · Electrical Eng. & Systems 2023-03-22 Zahra Tabatabaei , Adrian colomer , Kjersti Engan , Javier Oliver , Valery Naranjo

Image segmentation, one of the most critical vision tasks, has been studied for many years. Most of the early algorithms are unsupervised methods, which use hand-crafted features to divide the image into many regions. Recently, owing to the…

Computer Vision and Pattern Recognition · Computer Science 2021-03-11 Qinghong Lin , Weichan Zhong , Jianglin Lu
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