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Gene finding is the task of identifying the locations of coding sequences within the vast amount of genetic code contained in the genome. With an ever increasing quantity of raw genome sequences, gene finding is an important avenue towards…

Genomics · Quantitative Biology 2025-05-07 Frederikke I. Marin , Dennis Pultz , Wouter Boomsma

Genetic information is encoded in a linear sequence of nucleotides, represented by letters ranging from thousands to billions. Mutations refer to changes in the DNA or RNA nucleotide sequence. Thus, mutation detection is vital in all areas…

Although the applications of Non-Homogeneous Poisson Processes to model and study the threshold overshoots of interest in different time series of measurements have proven to provide good results, they needed to be complemented with an…

Applications · Statistics 2023-09-15 Biviana Marcela Suárez-Sierra , Arrigo Coen , Carlos Alberto Taimal

In genomics, pattern matching against a sequence of nucleotides plays a pivotal role for DNA sequence alignment and comparing genomes. This helps tackling some diseases, such as cancer in humans. The complexity of searching biological…

Quantitative Methods · Quantitative Biology 2017-10-04 Fereshte Mozafari , Hossein Babashah , Somayyeh Koohi , Zahra Kavehvash

This article proposes a novel approach to statistical alignment of nucleotide sequences by introducing a context dependent structure on the substitution process in the underlying evolutionary model. We propose to estimate alignments and…

Statistics Theory · Mathematics 2011-07-18 Ana Arribas-Gil , Catherine Matias

Assessing the significance of alignment scores of optimally aligned DNA or amino acid sequences can be achieved via the knowledge of the score distribution of random sequences. But this requires obtaining the distribution in the…

Quantitative Methods · Quantitative Biology 2016-08-24 Pascal Fieth , Alexander K. Hartmann

Local explanation methods highlight the input tokens that have a considerable impact on the outcome of classifying the document at hand. For example, the Anchor algorithm applies a statistical analysis of the sensitivity of the classifier…

Machine Learning · Computer Science 2024-01-15 Alon Mor , Yonatan Belinkov , Benny Kimelfeld

Region anchors are the cornerstone of modern object detection techniques. State-of-the-art detectors mostly rely on a dense anchoring scheme, where anchors are sampled uniformly over the spatial domain with a predefined set of scales and…

Computer Vision and Pattern Recognition · Computer Science 2019-04-15 Jiaqi Wang , Kai Chen , Shuo Yang , Chen Change Loy , Dahua Lin

The paper presents methods for evaluating the accuracy of alignments between transcriptions and audio recordings. The methods have been applied to the Spoken British National Corpus, which is an extensive and varied corpus of natural…

Sound · Computer Science 2011-01-11 Ladan Baghai-Ravary , Sergio Grau , Greg Kochanski

Adaptation to local environments often occurs through natural selection acting on a large number of loci, each having a weak phenotypic effect. One way to detect these loci is to identify genetic polymorphisms that exhibit high correlation…

Populations and Evolution · Quantitative Biology 2015-03-20 Eric Frichot , Sean Schoville , Guillaume Bouchard , Olivier François

The most common tools for word-alignment rely on a large amount of parallel sentences, which are then usually processed according to one of the IBM model algorithms. The training data is, however, the same as for machine translation (MT)…

Computation and Language · Computer Science 2021-04-01 Vilém Zouhar , Daria Pylypenko

Machine Learning methods have of late made significant efforts to solving multidisciplinary problems in the field of cancer classification using microarray gene expression data. Feature subset selection methods can play an important role in…

Computational Engineering, Finance, and Science · Computer Science 2013-03-04 G. Prat , Ll. Belanche

This paper describes a linear-time algorithm that finds the longest stretch in a sequence of real numbers (``scores'') in which the sum exceeds an input parameter. The algorithm also solves the problem of finding the longest interval in…

Data Structures and Algorithms · Computer Science 2007-05-23 Miklós Csűrös

Genome analysis fundamentally starts with a process known as read mapping, where sequenced fragments of an organism's genome are compared against a reference genome. Read mapping is currently a major bottleneck in the entire genome analysis…

Hardware Architecture · Computer Science 2020-10-29 Mohammed Alser , Zülal Bingöl , Damla Senol Cali , Jeremie Kim , Saugata Ghose , Can Alkan , Onur Mutlu

In object detection, determining which anchors to assign as positive or negative samples, known as anchor assignment, has been revealed as a core procedure that can significantly affect a model's performance. In this paper we propose a…

Computer Vision and Pattern Recognition · Computer Science 2020-09-08 Kang Kim , Hee Seok Lee

An important component of any generation system is the mapping dictionary, a lexicon of elementary semantic expressions and corresponding natural language realizations. Typically, labor-intensive knowledge-based methods are used to…

Computation and Language · Computer Science 2007-05-23 Regina Barzilay , Lillian Lee

The most common gene regulation mechanism is when a transcription factor protein binds to a regulatory sequence to increase or decrease RNA transcription. However, transcription factors face two main challenges when searching for these…

Quantitative Methods · Quantitative Biology 2023-11-21 Lucas Hedström , Ludvig Lizana

The dictionary matching problem is to locate occurrences of any pattern among a set of patterns in a given text. Massive data sets abound and at the same time, there are many settings in which working space is extremely limited. We…

Data Structures and Algorithms · Computer Science 2013-01-29 Shoshana Marcus Dina Sokol

Lyrics alignment in long music recordings can be memory exhaustive when performed in a single pass. In this study, we present a novel method that performs audio-to-lyrics alignment with a low memory consumption footprint regardless of the…

Sound · Computer Science 2021-02-19 Emir Demirel , Sven Ahlbäck , Simon Dixon

This paper proposes an algorithm for alignment-free sequence comparison using Logical Match. Here, we compute the score using fuzzy membership values which generate automatically from the number of matches and mismatches. We demonstrate the…

Computational Engineering, Finance, and Science · Computer Science 2014-07-09 Sanil Shanker KP , Elizabeth Sherly , Jim Austin
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