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Epilepsy affects nearly 1% of the global population, of which two thirds can be treated by anti-epileptic drugs and a much lower percentage by surgery. Diagnostic procedures for epilepsy and monitoring are highly specialized and…
Drug-resistant epilepsy is traditionally characterized by pathologic cortical tissue comprised of seizure-initiating `foci'. These `foci' are thought to be embedded within an epileptic network whose functional architecture dynamically…
We study patterns of partial synchronization in a network of FitzHugh-Nagumo oscillators with empirical structural connectivity measured in human subjects. We report the spontaneous occurrence of synchronization phenomena that closely…
Periodic pulse train stimulation is generically used to study the function of the nervous system and to counteract disease-related neuronal activity, e.g., collective periodic neuronal oscillations. The efficient control of neuronal…
Neural synchrony in the brain at rest is usually variable and intermittent, thus intervals of predominantly synchronized activity are interrupted by intervals of desynchronized activity. Prior studies suggested that this temporal structure…
Bursting neurons are considered to be a potential cause of over-excitability and seizure susceptibility. The functional influence of these neurons in extended epileptic networks is still poorly understood. There is mounting evidence that…
Epilepsy is one of the most prevalent neurological conditions, where an epileptic seizure is a transient occurrence due to abnormal, excessive and synchronous activity in the brain. Electroencephalogram signals emanating from the brain may…
In this work we study the detection of weak stimuli by spiking neurons in the presence of certain level of noisy background neural activity. Our study has focused in the realistic assumption that the synapses in the network present…
Our brain is a complex information processing network in which the nervous system receives information from the environment to quickly react to incoming events or learns from experience to sharp our memory. In the nervous system, the brain…
Parkinson's Disease afflicts millions of individuals globally. Emerging as a promising brain rehabilitation therapy for Parkinson's Disease, Closed-loop Deep Brain Stimulation (CL-DBS) aims to alleviate motor symptoms. The CL-DBS system…
Neuromorphic engineering is a rapidly developing field that aims to take inspiration from the biological organization of neural systems to develop novel technology for computing, sensing, and actuating. The unique properties of such systems…
We propose a novel Coupled Hidden Markov Model to detect epileptic seizures in multichannel electroencephalography (EEG) data. Our model defines a network of seizure propagation paths to capture both the temporal and spatial evolution of…
In this paper, we investigated the neural spikes synchronisation in a neural network with synaptic plasticity and external perturbation. In the simulations the neural dynamics is described by the Hodgkin Huxley model considering chemical…
Epilepsy affects 50 million people worldwide and is one of the most common serious neurological disorders. Seizure detection and classification is a valuable tool for diagnosing and maintaining the condition. An automated classification…
Conventional deep brain stimulation (DBS) of basal ganglia uses high-frequency regular electrical pulses to treat Parkinsonian motor symptoms and has a series of limitations. Relatively new and not yet clinically tested optogenetic…
Epilepsy or the occurrence of epileptic seizures, is one of the world's most well-known neurological disorders affecting millions of people. Seizures mostly occur due to non-coordinated electrical discharges in the human brain and may cause…
Controlling the high-dimensional neural dynamics during epileptic seizures remains a significant challenge due to the nonlinear characteristics and complex connectivity of the brain. In this paper, we propose a novel framework, namely…
We illustrate the potential of neuromorphic control on the simple mechanical model of a pendulum, with both event-based actuation and sensing. The controller and the pendulum are regarded as event-based systems that occasionally interact to…
Since the earliest electroencephalography experiments, large scale oscillations have been observed in the mammalian brain. More recently, episodes of oscillation and bursting have been identified not only in the cerebral cortex and…
We study a network model of two conductance-based pacemaker neurons of differing natural frequency, coupled with either mutual excitation or inhibition, and receiving shared random inhibitory synaptic input. The networks may phase-lock…