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The ongoing explosion of genome sequence data is transforming how we reconstruct and understand the histories of biological systems. Across biological scales, from individual cells to populations and species, trees-based models provide a…

Populations and Evolution · Quantitative Biology 2025-12-08 Yun Deng , Shing H. Zhan , Yulin Zhang , Chao Zhang , Bingjie Chen

The presence of clusters of rare codons is known to negatively impact the efficiency and accuracy of protein production. In this paper, we demonstrate a statistical method of identifying such clusters in the coding sequence of a gene. Using…

Genomics · Quantitative Biology 2009-10-05 Lalit Ponnala

Motivation: Millions of genes in the modern species belong to only thousands of `gene families'. A gene family includes instances of the same gene in different species (orthologs) and duplicate genes in the same species (paralogs). Genes…

Populations and Evolution · Quantitative Biology 2012-05-04 Yu Zheng , Taoyang Wu , Louxin Zhang

In the problem of blind reconstruction of channel codes, the receiver does not have the knowledge of the channel code used at the transmitter and the aim is to identify this unknown channel code corresponding to the given received sequence.…

Information Theory · Computer Science 2017-10-13 Arti D. Yardi , Saravanan Vijayakumaran

A convex code is a binary code generated by the pattern of intersections of a collection of open convex sets in some Euclidean space. Convex codes are relevant to neuroscience as they arise from the activity of neurons that have convex…

Neurons and Cognition · Quantitative Biology 2018-07-10 Carina Curto , Elizabeth Gross , Jack Jeffries , Katherine Morrison , Zvi Rosen , Anne Shiu , Nora Youngs

Meiotic recombination is a fundamental feature of sexually reproducing species. It is often required for proper chromosome segregation and plays important role in adaptation and the maintenance of genetic diversity. The molecular mechanisms…

Populations and Evolution · Quantitative Biology 2024-06-05 Susan E. Johnston

Genetic Algorithms are a popular set of optimization algorithms often used to aid software testing. However, no work has been done to apply systematic software testing techniques to genetic algorithms because of the stochasticity and the…

Software Engineering · Computer Science 2018-08-06 Janette Rounds , Upulee Kanewala

Cyclicity of a convolutional code (CC) is relying on a nontrivial automorphism of the algebra F[x]/(x^n-1), where F is a finite field. If this automorphism itself has certain specific cyclicity properties one is lead to the class of…

Rings and Algebras · Mathematics 2007-07-16 Heide Gluesing-Luerssen , Wiland Schmale

Symmetry plays a central role in many areas of modern physics. Here we show that it also underpins the dual particle and wave nature of quantum systems. We begin by noting that a classical point particle breaks translational symmetry…

Quantum Physics · Physics 2012-03-21 Joan A. Vaccaro

Encoding information about continuous variables using noisy computational units is a challenge; nonetheless, asymptotic theory shows that combining multiple periodic scales for coding can be highly precise despite the corrupting influence…

Neurons and Cognition · Quantitative Biology 2013-08-22 Alexander Mathis , Andreas V. M. Herz , Martin B. Stemmler

This paper presents a new type of genetic algorithm for the set covering problem. It differs from previous evolutionary approaches first because it is an indirect algorithm, i.e. the actual solutions are found by an external decoder…

Neural and Evolutionary Computing · Computer Science 2010-07-05 Uwe Aickelin

We investigate the possibility of encoding multiple solutions of a problem in a single chromosome. The best solution encoded in an individual will represent (will provide the fitness of) that individual. In order to obtain some benefits the…

Neural and Evolutionary Computing · Computer Science 2021-10-22 Mihai Oltean

Group theoretical concepts are invoked in a specific model to explain how only twenty amino acids occur in nature out of a possible sixty four. The methods we use enable us to justify the occurrence of the recently discovered twenty first…

Biological Physics · Physics 2009-11-10 J. Balakrishnan

Monotone Boolean functions are a structurally important class of Boolean functions, but their restricted form imposes strong limitations on achievable nonlinearity. In this paper, we investigate whether evolutionary computation can evolve…

Neural and Evolutionary Computing · Computer Science 2026-04-21 Claude Carlet , Marko Čupić , Marko Ðurasevic , Domagoj Jakobovic , Luca Mariot , Stjepan Picek

The nature of the quantitative distribution of the 64 DNA codons in the human genome has been an issue of debate for over a decade. Some groups have proposed that the quantitative distribution of the DNA codons ordered as a rank-frequency…

Genomics · Quantitative Biology 2015-01-06 Bohdan B. Khomtchouk

A major ambition of systems science is to uncover the building blocks of any biological network to decipher how cellular function emerges from their interactions. Here, we introduce a graph representation of the information flow in these…

Molecular Networks · Quantitative Biology 2020-06-15 Flaviano Morone , Ian Leifer , Hernan A. Makse

The function of the organism hinges on the performance of its information-processing networks, which convey information via molecular recognition. Many paths within these networks utilize molecular codebooks, such as the genetic code, to…

Biomolecules · Quantitative Biology 2010-07-27 Tsvi Tlusty

In the past decade, advances in genome sequencing have allowed researchers to uncover the history of hybridization in diverse groups of species, including our own. Although the field has made impressive progress in documenting the extent of…

Populations and Evolution · Quantitative Biology 2021-03-23 Benjamin M Moran , Cheyenne Payne , Quinn Langdon , Daniel L Powell , Yaniv Brandvain , Molly Schumer

Cylindrical algebraic decomposition (CAD) is an important tool for working with polynomial systems, particularly quantifier elimination. However, it has complexity doubly exponential in the number of variables. The base algorithm can be…

Symbolic Computation · Computer Science 2016-10-03 Matthew England , James H. Davenport

It has been repeatedly proposed to expand the scope for SETI, and one of the suggested alternatives to radio is the biological media. Genomic DNA is already used on Earth to store non-biological information. Though smaller in capacity, but…

Other Quantitative Biology · Quantitative Biology 2017-06-13 Vladimir I. shCherbak , Maxim A. Makukov